Science | Nature | Cell | View More
Natural Products
Coronarin A
Coronarin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Coronarin A
Price:
CAS No.: 119188-33-9
Catalog No.: CFN99301
Molecular Formula: C20H28O2
Molecular Weight: 300.4 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The rhizomes of Hedychium coronarium
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Molecular Biology Institute of ... (Spain)
  • Rio de Janeiro State University (Brazil)
  • Macau University of Science and... (China)
  • University Medical Center Mainz (Germany)
  • University of Dicle (Turkey)
  • Universita' Degli Studi Di Cagl... (Italy)
  • Washington State University (USA)
  • Utrecht University (Netherlands)
  • Sapienza University of Rome (Italy)
  • National Cancer Institute (USA)
  • Medical University of Gdansk (Poland)
  • More...
Package
Featured Products
Ononin

Catalog No: CFN99136
CAS No: 486-62-4
Price: $50/20mg
Matairesinol

Catalog No: CFN98983
CAS No: 580-72-3
Price: $318/10mg
beta-Eudesmol

Catalog No: CFN99537
CAS No: 473-15-4
Price: $288/20mg
Diosbulbin B

Catalog No: CFN98014
CAS No: 20086-06-0
Price: $80/20mg
Bakuchiol

Catalog No: CFN99047
CAS No: 10309-37-2
Price: $40/20mg
5-Hydroxy-1,7-bis(4-hydroxyphenyl)...

Catalog No: CFN96291
CAS No: 1269839-24-8
Price: $318/10mg
Neomangiferin

Catalog No: CFN98122
CAS No: 64809-67-2
Price: $80/20mg
Acteoside

Catalog No: CFN97048
CAS No: 61276-17-3
Price: $60/20mg
Vomifoliol

Catalog No: CFN98245
CAS No: 23526-45-6
Price: $ /
Geniposidic acid

Catalog No: CFN98337
CAS No: 27741-01-1
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC proliferation, it effectively suppresses the growth factor induced tube formation of HUVEC at the concentration of 10 microg/mL. Coronarin A has anti-inflammatory activity, it exhibits potent inhibition (IC50 <6.1708g/mL) against fMLP-induced superoxide production and elastase release.
Targets: Immunology & Inflammation related
In vitro:
Chem Pharm Bull (Tokyo). 2012;60(2):246-50.
Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.[Pubmed: 22293485]
The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine.
METHODS AND RESULTS:
From this plant, two new labdanes, 15-methoxylabda-8(17),11E,13-trien-16,15-olide (1) and 16-methoxylabda-8(17),11E,13-trien-15,16-olide (3), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (2), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), Coronarin A (5), and corronarin E (6) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
CONCLUSIONS:
Among of them, compounds 1-3 were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 μM. Compounds 1 and 3 showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC(50) values of 46.0±1.3 and 12.7±0.3 μM. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium.
Phytother Res. 2010 Jul;24(7):1009-13. doi: 10.1002/ptr.3057.
Labdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cells.[Pubmed: 19960422]

METHODS AND RESULTS:
Seven labdane-type diterpenes, coronarin E, Coronarin A, yunnanCoronarin A, yunnancoronarin B, hedyforrestin B, villosin, and hedyforrestin C were isolated from the rhizome of Hedychium gardnerianum and evaluated for cytotoxic activity against human small cell lung cancer (NCI-H187) and non-cancerous Vero cells. The results showed that villosin exhibited potent cytotoxic activity with IC(50) of 0.40 microM, which was higher than that of the drug ellipticine (IC(50) 1.79 microM). Moreover, ellipticine was very toxic to Vero cells (IC(50) 7.47 microM) whereas the toxicity of villosin was undetectable at concentration lower than 166.42 microM.
CONCLUSIONS:
The results have indicated that the lactone ring is essential for high cytotoxic activity and that the presence of a hydroxyl group at the 6 or 7 position causes decrease in activity. The very high cytotoxicity against the NCI-H187 cells and the exceptionally high selectivity index (>416) of villosin suggested that this compound may be used as a potential lead molecule for antitumor therapeutic development.
Planta Med., 2011, 77(12):1344-1344.
New labdane-type diterpenoids and anti-inflammatory constituents from the rhizome of Hedychium coronarium[Reference: WebLink]

METHODS AND RESULTS:
Hedychium coronarium J.Koenig (Zingiberaceae) is a terrestrial epiphytic herb, which is distribution in India, Malaysia, Vietnam, southern China and Taiwan [1]. Two new labdane-type diterpenoids, hedychicoronarin (1) and peroxycoronarin D (2), together with eleven known compounds, including calcaratarin (3), (+)-Coronarin A (4), coronarin D (5), coronarin D methyl ether (6), (E)-labda-8(17),12-diene-15,16-dial (7), ergosta-4,6,8(14),22-tetraen-3-one (8), β-sitostenone (9), stigmasta-4,22-dien-3-one (10), oleic acid (11), stearic acid (12), and palmitic acid (13) have been isolated from the rhizomes of Hedychium coronarium. The structure of new compounds 1 and 2 was determined through spectral analyses including extensive 2D NMR data.
CONCLUSIONS:
Among the isolates, calcaratarin (3), Coronarin A (4), (E)-labda-8(17),12-diene-15,16-dial (7), and oleic acid (11) exhibited potent inhibition (IC50 <6.17μg/mL) against fMLP-induced superoxide production and elastase release.
Coronarin A Description
Source: The rhizomes of Hedychium coronarium
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
7-Neohesperidosides

Catalog No: CFN95018
CAS No: 28383-41-7
Price: $288/5mg
Isogambogic acid

Catalog No: CFN95440
CAS No: 149655-52-7
Price: $318/10mg
Somnifericin

Catalog No: CFN95280
CAS No: 173693-57-7
Price: $318/5mg
3-Oxo-alpha-ilexanolic acid

Catalog No: CFN95496
CAS No: N/A
Price: $413/5mg
Methyl ganoderenate D

Catalog No: CFN95572
CAS No: 748136-03-0
Price: $413/5mg
Notoptol

Catalog No: CFN95218
CAS No: 88206-49-9
Price: $318/5mg
Lucidumol A

Catalog No: CFN95059
CAS No: 217476-73-8
Price: $318/5mg
5-Hydroxy-4a,8-dimethyl-3-methylen...

Catalog No: CFN95522
CAS No: 114579-31-6
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3289 mL 16.6445 mL 33.2889 mL 66.5779 mL 83.2224 mL
5 mM 0.6658 mL 3.3289 mL 6.6578 mL 13.3156 mL 16.6445 mL
10 mM 0.3329 mL 1.6644 mL 3.3289 mL 6.6578 mL 8.3222 mL
50 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.3316 mL 1.6644 mL
100 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.6658 mL 0.8322 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Planta Med., 1988, 54(54):311-5.
Cytotoxic Diterpenes from the Rhizomes of Hedychium coronarium[Reference: WebLink]

METHODS AND RESULTS:
Four new labdane-type diterpenes, Coronarin A, CoronarinB, Coronarin C, and Coronarin D, and one known labdane-type diterpene, (E)-labda-8(17), 12- diene-15, 16-dial were isolated as cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. The structures were established by chemical and spectroscopic methods.
Bioorg Med Chem Lett. 2003 Jun 16;13(12):2009-12.
A study on the synthesis of antiangiogenic (+)-coronarin A and congeners from (+)-sclareolide.[Pubmed: 12781184]

METHODS AND RESULTS:
Coronarin A 1, epi-Coronarin A 2 and some synthetic intermediates 14a and 14b synthesized from sclareolide exhibit good growth inhibition activities on HUVEC proliferation. In particular, Coronarin A 1 and epi-Coronarin A 2 effectively suppressed the growth factor induced tube formation of HUVEC at the concentration of 10 micro g/mL.
Ononin

Catalog No: CFN99136
CAS No: 486-62-4
Price: $50/20mg
Matairesinol

Catalog No: CFN98983
CAS No: 580-72-3
Price: $318/10mg
beta-Eudesmol

Catalog No: CFN99537
CAS No: 473-15-4
Price: $288/20mg
Diosbulbin B

Catalog No: CFN98014
CAS No: 20086-06-0
Price: $80/20mg
Bakuchiol

Catalog No: CFN99047
CAS No: 10309-37-2
Price: $40/20mg
5-Hydroxy-1,7-bis(4-hydroxyphenyl)...

Catalog No: CFN96291
CAS No: 1269839-24-8
Price: $318/10mg
Neomangiferin

Catalog No: CFN98122
CAS No: 64809-67-2
Price: $80/20mg
Acteoside

Catalog No: CFN97048
CAS No: 61276-17-3
Price: $60/20mg
Vomifoliol

Catalog No: CFN98245
CAS No: 23526-45-6
Price: $ /
Geniposidic acid

Catalog No: CFN98337
CAS No: 27741-01-1
Price: $30/20mg
Tags: buy Coronarin A | Coronarin A supplier | purchase Coronarin A | Coronarin A cost | Coronarin A manufacturer | order Coronarin A | Coronarin A distributor