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    Natural Products
    Deapi-platycodin D
    Deapi-platycodin D
    Information
    CAS No. 78763-58-3 Price $268 / 10mg
    Catalog No.CFN90472Purity>=98%
    Molecular Weight1093.21Type of CompoundTriterpenoids
    FormulaC52H84O24Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $288.1 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Deapi-platycodin D

    Deapi-platycodin D
    Product Name Deapi-platycodin D
    CAS No.: 78763-58-3
    Catalog No.: CFN90472
    Molecular Formula: C52H84O24
    Molecular Weight: 1093.21 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: NOS
    Source: The roots of Platycodon grandiflorum.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $268 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • J Sep Sci.2020, 201901140
  • Sci. Rep.2015, 14-23
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  • Journal of Apicultural Research2021, 60(1).
  • Int Immunopharmacol.2020, 90:107268.
  • Front Pharmacol.2018, 9:756
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Expectorants Compound Library
  • Triterpenoids Compound Library
  • NOS Inhibitor Library
  • Biological Activity
    Description: Deapi-platycodin D has anti-inflammatory activity, it can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extract of APG as expectorants in diverse inflammatory pulmonary diseases.
    Targets: NOS
    In vitro:
    Natural Product Sciences, 2008, 14(4):274-80.
    Compositional analysis of major saponins and anti-inflammatory activitiy of steam-processed platycodi radix under pressure[Reference: WebLink]
    Platycosides are the saponins in Platycodi Radix and they have several beneficial effects such as anti-inflammatory and anti-obesity activities. This study was designed to determine the changes in the saponin composition in Platycodi Radix (platycosides) after being processed under steam and pressure and to investigate the anti-inflammatory effects of their extracts.
    METHODS AND RESULTS:
    The change of the platycoside compositions was investigated after 1, 2, 3, 6 and 9h heat processing of Platycodi Radices by using HPLC coupled with an evaporative light scattering detection (ELSD) system. After heat treatment (125 °C, 1, 2, 3, 6 and 9 h), the contents of several platycosides such as platycoside E, platycodin D3, platycodin D, polygalacin D, and platycodin A decreased as the processing time was longer. While the total contents of the saponins decreased, the contents of deapi-forms of deapi-platycoside E, Deapi-platycodin D3, and Deapi-platycodin D increased relatively. These results indicate that the linkage between apiose and xylose located at C-28 is labile to heat and pressure. The LPS-induced iNOS inhibitory activities of the samples treated for 1 and 2 hours were enhanced and after then, the activities were reduced.
    CONCLUSIONS:
    These results suggested that heat treatment of the samples affect the content of the total saponins and the saponin content may be the important criteria representing the anti-inflammatory activity.
    Evid Based Complement Alternat Med . 2013;2013:560417.
    Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication[Pubmed: 24489585]
    Abstract Hepatitis C virus (HCV) infection is a major cause of liver disease, including cirrhosis and hepatocellular carcinoma. Due to significant adverse effects and emergence of resistant strains of currently developed anti-HCV agents, plant extracts have been considered to be potential sources of new bioactive compounds against HCV. The aim of this study was to evaluate the functional effects of triterpenoid saponins contained in the root extract of Platycodon grandiflorum (PG) on viral enzyme activities and replication in both HCV replicon cells and cell culture grown HCV- (HCVcc-) infected cells. Inhibitory activities of triterpenoid saponins from PG were verified by NS5B RNA-dependent RNA polymerase assay and were further confirmed in the context of HCV replication. Six triterpenoid saponins (platycodin D, platycodin D2, platycodin D3, deapioplatycodin D, deapioplatycodin D2, and platyconic acid A), PG saponin mixture (PGSM), were identified as active components exerting anti-HCV activity. Importantly, PGSM exerted synergistic anti-HCV activity in combination with either interferon- α or NS5A inhibitors. We demonstrated that combinatorial treatment of PGSM and IFN- α efficiently suppressed colony formation with significant reduction in drug resistant variant of HCV. These data suggest that triterpenoid saponin may represent a novel anti-HCV therapeutic agent.
    Deapi-platycodin D Description
    Source: The roots of Platycodon grandiflorum.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9147 mL 4.5737 mL 9.1474 mL 18.2947 mL 22.8684 mL
    5 mM 0.1829 mL 0.9147 mL 1.8295 mL 3.6589 mL 4.5737 mL
    10 mM 0.0915 mL 0.4574 mL 0.9147 mL 1.8295 mL 2.2868 mL
    50 mM 0.0183 mL 0.0915 mL 0.1829 mL 0.3659 mL 0.4574 mL
    100 mM 0.0091 mL 0.0457 mL 0.0915 mL 0.1829 mL 0.2287 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Sep Sci. 2014 Jan;37(1-2):61-8.
    Glycosylated platycosides: identification by enzymatic hydrolysis and structural determination by LC-MS/MS.[Pubmed: 24327461]
    In this study, enzymatic hydrolysis and chemometric methods were utilized to discriminate glycosylated platycosides in the extract of Platycodi Radix by LC-MS.
    METHODS AND RESULTS:
    Laminarinase, whose enzymatic activity was evaluated using gentiobiose and laminaritriose, was a suitable enzyme to identify the glycosylated platycosides. The laminarinase produced Deapi-platycodin D and platycodin D from the isolated deapi-platycoside E and platycoside E through the loss of two glucose units by enzymatic reaction, respectively. After hydrolyzing a crude extract by laminarinase, the reconstructed total ion chromatogram generated by a chemometric technique sorted peaks of deglycosylated platycosides easily. Structural information of the glycosylated isomers was revealed through fragment ions generated by the sodiated C0β ion corresponding to reduced disaccharides in the positive MS(4) spectra. Characteristic fragment ions of Glc-(1→6)-Glc moieties were observed through ring cleavages of (0,2)A0β, (0,3)A0β, and (0,4)A0β, whereas Glc-(1→3)-Glc moieties produced only (0,3)A0β ions. Lithium-adducted platycosides allowed more detailed structural analysis of glycosidic bond cleavage corresponding to Y1β and B1β in addition to ring cleavage.
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