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    Natural Products
    Curcumenol
    Information
    CAS No. 19431-84-6 Price $70 / 20mg
    Catalog No.CFN92614Purity>=98%
    Molecular Weight234.3Type of CompoundSesquiterpenoids
    FormulaC15H22O2Physical DescriptionPowder
    Download COA    MSDS    SDF    ManualSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $17.7 / In-stock
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    Curcumenol

    Curcumenol
    Product Name Curcumenol
    CAS No.: 19431-84-6
    Catalog No.: CFN92614
    Molecular Formula: C15H22O2
    Molecular Weight: 234.3 g/mol
    Purity: >=98%
    Type of Compound: Sesquiterpenoids
    Physical Desc.: Powder
    Targets: P450 (e.g. CYP17) | NADPH-oxidase | NF-魏B | p65 | I魏B
    Source: The rhizomes of Curcuma zedoaria
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $70 / 20mg
    Download: COA    MSDS    SDF    Manual
    Similar structural: Comparison (Web)  (SDF)
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  • Antiviral Res.2013, 98(3):386-93
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Biochem Systematics and Ecology2017, 11-18
  • Antioxidants (Basel).2020, 9(6):544.
  • Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)
  • Journal of Functional Foods2017, 30:30-38
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • Sci Rep. 2018, 462(8)
  • Front Chem.2022, 10:1048467.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • NADPH-oxidase Inhibitor Library
  • Biological Activity
    Description: Curcumenol possesses a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
    Targets: P450 (e.g. CYP17) | NADPH-oxidase | NF-κB | p65 | IκB
    In vitro:
    Phytother Res. 2010 Aug;24(8):1213-6.
    Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes.[Pubmed: 20148399 ]
    Curcumenol, one of the major components of Zedoary turmeric oil, has been widely used to treat cancer and inflammation. As an antibiotic or anticancer drug, Curcumenol is highly likely to be used in combination with various synthetic drugs in most cases, thus it is necessary to evaluate potential pharmacokinetic drug-drug interactions induced by Curcumenol.
    METHODS AND RESULTS:
    In this study, the inhibitory effects of Curcumenol on seven CYP isoforms were investigated, and the results demonstrated that only CYP3A4 was strongly inhibited (IC(50) = 12.6 +/- 1.3 microM). Kinetic analysis showed the inhibition type was competitive with K(i) value of 10.8 microM. Time- and NADPH-dependent inhibitions were also investigated to show Curcumenol is not a mechanism-based inhibitor. Employing these in vitro data and maximum plasma concentration of Curcumenol in human predicted from beagle dog's in vivo pharmacokinetic data, the change in AUC of victim drugs was predicted to be 0.4%, which suggested that Curcumenol may be safely used without inducing metabolic drug-drug interaction through P450 inhibition. Nevertheless, due to the limited pharmacokinetic data available for Curcumenol in humans, it is still not possible to evaluate its potential clinical effects on human patients from in vitro data.
    CONCLUSIONS:
    Thus, the magnitude of drug-drug interaction (DDI) induced by Curcumenol warrants further investigation.
    Curcumenol Description
    Source: The rhizomes of Curcuma zedoaria
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Int J Mol Sci. 2015 Mar 6;16(3):5180-93.
    Spectrofluorometric and molecular docking studies on the binding of curcumenol and curcumenone to human serum albumin.[Pubmed: 25756376]
    Curcumenol and curcumenone are two major constituents of the plants of medicinally important genus of Curcuma, and often govern the pharmacological effect of these plant extracts.
    METHODS AND RESULTS:
    Additions of these sesquiterpenes to HSA produced significant fluorescence quenching and blue shifts in the emission spectra of HSA. Analysis of the fluorescence data pointed toward moderate binding affinity between the ligands and HSA, with curcumenone showing a relatively higher binding constant (2.46 × 105 M-1) in comparison to Curcumenol (1.97 × 104 M-1). Cluster analyses revealed that site I is the preferred binding site for both molecules with a minimum binding energy of -6.77 kcal·mol-1. However, binding of these two molecules to site II cannot be ruled out as the binding energies were found to be -5.72 and -5.74 kcal·mol-1 for Curcumenol and curcumenone, respectively.
    CONCLUSIONS:
    The interactions of both ligands with HSA involved hydrophobic interactions as well as hydrogen bonding.
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