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    Natural Products
    Deoxy euphorbia factor L1
    Deoxy euphorbia factor L1
    Information
    CAS No. 247099-01-0 Price $318 / 10mg
    Catalog No.CFN95340Purity>=98%
    Molecular Weight536.7Type of CompoundDiterpenoids
    FormulaC32H40O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $229.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Deoxy euphorbia factor L1

    Deoxy euphorbia factor L1
    Product Name Deoxy euphorbia factor L1
    CAS No.: 247099-01-0
    Catalog No.: CFN95340
    Molecular Formula: C32H40O7
    Molecular Weight: 536.7 g/mol
    Purity: >=98%
    Type of Compound: Diterpenoids
    Physical Desc.: Powder
    Source: The herbs of Euphorbia pekinensis Rupr
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $318 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • Pharmaceutics.2020, 12(9):845.
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Korean J of Pharmacognosy2020, 51,49-54.
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  • Drug Des Devel Ther.2020, 14:5189-5204.
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  • Exp Parasitol.2018, 194:67-78
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Deoxy euphorbia factor L1 showed potent inhibition against lung cancer A549 cells, with an IC50 value of 17.51 ± 0.85 μM.
    In vitro:
    Molecules, 2017 Aug 25;22(9):1412.
    Structure Identification and In Vitro Anticancer Activity of Lathyrol-3-phenylacetate-5,15-diacetate[Pubmed: 28841191]
    Natural products from the genus Euphorbia show attention-attracting activities, such as anticancer activity. In this article, classical isolation and structure identification were used in a study on Caper Euphorbia Seed. Subsequently, MTT and wound healing assays, flow cytometry, western blotting, Hoechst 33258 staining and fluorescence microscopy examination were applied to investigate the anticancer activity of the obtained compounds. In a result, lathyrol-3-phenyl- acetate-5,15-diacetate (Deoxy euphorbia factor L1, DEFL1) was isolated from Caper Euphorbia Seed. Moreover, the NMR signals were totally assigned. DEFL1 showed potent inhibition against lung cancer A549 cells, with an IC50 value of 17.51 ± 0.85 μM. Furthermore, DEFL1 suppressed wound healing of A549 cells in a concentration-dependent manner. Mechanically, DEFL1 induced apoptosis, with involvement of an increase of reactive oxygen species (ROS), decrease of mitochondrial membrane potential (ΔΨm), release of cytochrome c, activity raise of caspase-9 and 3. Characteristic features of apoptosis were observed by fluorescence microscopy. In summary, DEFL1 inhibited growth and induced apoptosis in lung cancer A549 cells via a mitochondrial pathway.
    Deoxy euphorbia factor L1 Description
    Source: The herbs of Euphorbia pekinensis Rupr
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8632 mL 9.3162 mL 18.6324 mL 37.2648 mL 46.581 mL
    5 mM 0.3726 mL 1.8632 mL 3.7265 mL 7.453 mL 9.3162 mL
    10 mM 0.1863 mL 0.9316 mL 1.8632 mL 3.7265 mL 4.6581 mL
    50 mM 0.0373 mL 0.1863 mL 0.3726 mL 0.7453 mL 0.9316 mL
    100 mM 0.0186 mL 0.0932 mL 0.1863 mL 0.3726 mL 0.4658 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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