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    Natural Products
    Daphnenone
    Information
    CAS No. 936006-13-2 Price
    Catalog No.CFN92257Purity>=98%
    Molecular Weight252.3Type of CompoundPhenols
    FormulaC17H16O2Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Daphnenone

    Daphnenone
    Product Name Daphnenone
    CAS No.: 936006-13-2
    Catalog No.: CFN92257
    Molecular Formula: C17H16O2
    Molecular Weight: 252.3 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Source: The roots of Daphne odora
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
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  • Process Biochemistry2019, 85:106-115
  • BMC Complement Altern Med.2017, 17(1):393
  • Molecules.2017, 22(6)
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  • Front Cell Infect Microbiol.2018, 8:292
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cytotoxic Compound Library
  • Phenols Compound Library
  • Biological Activity
    Description: Daphnenone shows cytotoxic activity against the tumor cells of human melanoma A375-S2 , with the IC(50) value of 29.8 uM.
    In vitro:
    J Asian Nat Prod Res. 2012;14(11):1020-6.
    Two new compounds with cytotoxic activity on the human melanoma A375-S2 cells from Daphne giraldii callus cells.[Pubmed: 23106433 ]

    METHODS AND RESULTS:
    Four compounds were isolated from Daphne giraldii callus cells, and their structures were characterized as Daphnenone (1), daphnolon (2), R-( - )-1-(4'-hydroxyphenyl)-3-hydroxy-5-phenyl-1,5-pentandione (3), and S-(+)-daphneolone-4'-O-β-d-glucoside (4) on the basis of MS, NMR spectrographic analysis, and chemical methods. All of the four compounds possessed C6-C5-C6 carbon skeleton, and among them, 3 and 4 were two new compounds.
    CONCLUSIONS:
    In activity screening test, compounds 1, 2, 3, and 4 showed different degrees of cytotoxic activity against the tumor cells of human melanoma A375-S2 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium hydrobromide method, with IC(50) values of 29.8, 51.0, 41.0, and 150.0 μM, respectively. Furthermore, we found the important target which could explain the cytotoxic mechanism of the four compounds by using autodock 4.0, a structure-guided discovery approach, and the important residues CYS532, GLY534, and SER535 of B-Raf kinase have been discovered.
    Nat Prod Res. 2006 Dec;20(14):1290-4.
    Two new chemical constituents from Daphne odora Thunb. var. marginata.[Pubmed: 17393653 ]

    METHODS AND RESULTS:
    Two new phenolic constituents, Daphnenone (1) and daphneone (2), were isolated from the stem bark of Daphne odora Thunb. var. marginata. Their structures were established on the basis of spectroscopic analysis. Compounds 1 and 2 were tested for cytotoxic activity by MTT assays on five human tumour cell lines, K562, A549, MCF-7, LOVO and HepG2.
    CONCLUSIONS:
    Compound 1 showed obvious cytotoxic activity against all the five cell lines.
    Daphnenone Description
    Source: The roots of Daphne odora
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9635 mL 19.8177 mL 39.6354 mL 79.2707 mL 99.0884 mL
    5 mM 0.7927 mL 3.9635 mL 7.9271 mL 15.8541 mL 19.8177 mL
    10 mM 0.3964 mL 1.9818 mL 3.9635 mL 7.9271 mL 9.9088 mL
    50 mM 0.0793 mL 0.3964 mL 0.7927 mL 1.5854 mL 1.9818 mL
    100 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.7927 mL 0.9909 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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