ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $368 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Int J Mol Sci.2021, 22(19):10220.Yakugaku Zasshi.2018, 138(4):571-579Foods.2021, 10(11):2754.Appl. Sci.2021, 11(19),9343.J Int Med Res....2021...Anal Bioanal Chem.2016, 408(1):177-90. Chem Biol Interact.2019, 298:1-7Int J Mol Sci.2021, 22(8):4211.
J Pharmaceutical Research Int....2021...J Nat Prod.2015, 78(6):1339-4Evid Based Complement Alternat Me...2020...J Mol Med (Berl).2018, 96(7):661-672J Food Compos Anal2017, 62:197-204Journal of Third Military Medical...2018...Sci Rep.2021, 11(1):14180. Process Biochemistry2019, 87:213-220
BMC Complement Altern Med....2017...Life Sci.2021, 286:120019. J Food Sci Technol.2022, 59(1):212-219.Free Radic Biol Med.2017, 112:191-199J Ethnopharmacol.2020, 249:112381Plants (Basel).2021, 10(6):1119.J Nat Prod.2018, 81(4):966-975
Our products had been exported to the following research institutions and universities, And still growing.
Deutsches Krebsforschungszentrum (Germany)University of Helsinki (Finland)Universidad Veracuzana (Mexico)Max-Planck-Insitut (Germany)
University of Illinois at Chicago (USA)Instytut Nawozów Sztucznych w ... (Poland)Utah State University (USA)Uniwersytet Jagielloński w Kra... (Poland)
University of Bonn (Germany)Subang Jaya Medical Centre (Malaysia)University of Minnesota (USA)
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The Korea Journal of Herbology2020, 35(3):33-45. Phytochemistry Letters2017, 449-455Eur J Neurosci.2021, 53(11):3548-3560.Phys Chem Chem Phys.2018, 20(23):15986-15994Reprod Toxicol.2020, 96:1-10. Food Research2021, 5(1):65-71Bioorg Med Chem.2020, 28(12):115553.Plant Growth Regulation2020, 90(2):383-392Molecules.2021, 26(12):3652.Sci Rep.2019, 9(1):4646
Related Screening Libraries
||Ganoderol B is a potent α-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of α-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.
|Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum |
|Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum[Pubmed: 21596546]|
α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (Ganoderol B). It was found to have high α-glucosidase inhibition, with an IC(50) of 48.5 μg/ml (119.8 μM).
Copyright © 2011 Elsevier GmbH. All rights reserved.|
|Bioorg Med Chem. 2007 Jul 15;15(14):4966-72. Epub 2007 Apr 25. |
|The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.[Pubmed: 17499997]|
|Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by Ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that Ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that Ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.|
Ganoderol B Description
||The fruiting body of Ganoderma lucidum
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Phytomedicine. 2011 Sep 15;18(12):1053-5. |
|Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum.[Pubmed: 21596546]|
|α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (Ganoderol B). It was found to have high α-glucosidase inhibition, with an IC(50) of 48.5 μg/ml (119.8 μM).|