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    Natural Products
    Daphnin
    Daphnin
    Information
    CAS No. 486-55-5 Price
    Catalog No.CFN80132Purity>=98%
    Molecular Weight340.3Type of CompoundCoumarins
    FormulaC15H16O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Daphnin

    Daphnin
    Product Name Daphnin
    CAS No.: 486-55-5
    Catalog No.: CFN80132
    Molecular Formula: C15H16O9
    Molecular Weight: 340.3 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Source: The roots of Wikstroemia indica (Linn.) C. A. Mey.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
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  • BMC Complement Altern Med.2014, 14:352
  • Nutrients.2018, 10(7)
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Korean J of Medicinal Crop Science2018, 220-226
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Coumarins Compound Library
  • Biological Activity
    Description: Daphnin can contribute to the allergic potential of chamomile.
    In vitro:
    Phytomedicine. 2001 Jul;8(4):302-5.
    Antimicrobial evaluation of coumarins and flavonoids from the stems of Daphne gnidium L.[Pubmed: 11515721]
    The antimicrobial activity of stems methanol extract from Daphne gnidium L. collected from Sardinia (Italy) was evaluated against 6 strains of standard and clinical isolated gram (+/-) bacteria.
    METHODS AND RESULTS:
    The antimicrobial effect on two strains of fungi was also tested. The extract in toto exhibited antibacterial activity against Bacillus lentus and Escherichia coli, but was inactive against fungi. Four coumarins (daphnetin, Daphnin, acetylumbelliferone, daphnoretin) and seven flavonoids (luteolin, orientin, isoorientin, apigenin-7-O-glucoside, genkwanin, 5-O-beta-D-primeverosyl genkwanine, 2,5,7,4'-tetrahydroxyisoflavanol) present in the plant extract were also investigated against the same strains of bacteria and fungi assayed for the crude extract.
    CONCLUSIONS:
    The most active compounds were daphnetin, genkwanin, and 2,5,7,4'-tetrahydroxyisoflavanol.
    Daphnin Description
    Source: The roots of Wikstroemia indica (Linn.) C. A. Mey.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9386 mL 14.6929 mL 29.3858 mL 58.7717 mL 73.4646 mL
    5 mM 0.5877 mL 2.9386 mL 5.8772 mL 11.7543 mL 14.6929 mL
    10 mM 0.2939 mL 1.4693 mL 2.9386 mL 5.8772 mL 7.3465 mL
    50 mM 0.0588 mL 0.2939 mL 0.5877 mL 1.1754 mL 1.4693 mL
    100 mM 0.0294 mL 0.1469 mL 0.2939 mL 0.5877 mL 0.7346 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Food Chem. 2013 Nov 1;141(1):54-9.
    Coumarins of Matricaria chamomilla L.: aglycones and glycosides.[Pubmed: 23768326 ]
    The identity and quantity of coumarin-like compounds in leaves and anthodia of Matricaria chamomilla L. were studied by LC-DAD and NMR. So far, two monosubstituted coumarins, herniarin and umbelliferone, and two herniarin precursors were identified therein.
    METHODS AND RESULTS:
    In this paper, two other coumarin glycosides and one aglycone were confirmed. Skimmin (umbelliferone-7-O-β-d-glucoside), Daphnin (daphnetin-7-O-β-d-glucoside) and daphnetin (7,8-dihydroxycoumarin) were found for the first time in diploid and tetraploid leaves and anthodia of M. chamomilla L.
    CONCLUSIONS:
    Daphnetin is known as a strong sensitizer, so this compound and its glycosidic derivative can contribute to the allergic potential of chamomile. Commercial chamomile preparations were tested for their presence.
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