Magnaldehyde B | CAS:92829-72-6 Manufacturer ChemFaces

Magnaldehyde B

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Size /Price /Stock	10 mM * 1 mL in DMSO / $289.1 / In-stock
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Description:

Magnaldehyde B is a natural lipase inhibitor(IC50= 96.96 uM). Magnaldehyde B can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.

In vitro:

J Chromatogr A. 2015 May 1;1392:20-7.

Fabrication of enzyme-immobilized halloysite nanotubes for affinity enrichment of lipase inhibitors from complex mixtures.[Pubmed: 25798866 ]

Lipase is the key enzyme for catalyzing triglyceride hydrolysis in vivo, and lipase inhibitors have been used in the management of obesity.
METHODS AND RESULTS:
We present the first report on the use of lipase-adsorbed halloysite nanotubes as an efficient medium for the selective enrichment of lipase inhibitors from natural products. A simple and rapid approach was proposed to fabricate lipase-adsorbed nanotubes through electrostatic interaction. Results showed that more than 85% lipase was adsorbed into nanotubes in 90 min, and approximately 80% of the catalytic activity was maintained compared with free lipase. The specificity and reproducibility of the proposed approach were validated by screening a known lipase inhibitor (i.e., orlistat) from a mixture that contains active and inactive compounds. Moreover, we applied this approach with high performance liquid chromatography-mass spectrometry technique to screen lipase inhibitors from the Magnoliae cortex extract, a medicinal plant used for treating obesity. Two novel biphenyl-type natural lipase inhibitors magnotriol A and Magnaldehyde B were identified, and their IC50 values were determined as 213.03 and 96.96 μM, respectively.
CONCLUSIONS:
The ligand-enzyme interactions of Magnaldehyde B were further investigated by molecular docking. Our findings proved that enzyme-adsorbed nanotube could be used as a feasible and selective affinity medium for the rapid screening of enzyme inhibitors from complex mixtures.

Phytother Res. 2013 Sep;27(9):1419-22.

Apoptosis-inducing and antitumor activity of neolignans isolated from Magnolia officinalis in HeLa cancer cells.[Pubmed: 23192855 ]

Two neolignans, 4'-methoxymagndialdehyde (1) and Magnaldehyde B (2), were isolated from the stem bark of Magnolia officinalis (Magnoliaceae), evaluated for apoptosis-inducing effects in human cervical epitheloid carcinoma HeLa cells.
METHODS AND RESULTS:
The apoptosis-inducing activity of compounds 1 and 2 were assessed by DNA content using flow cytometric analysis. In the immunoblotting analysis, the treatment with 1 and 2 resulted in the cleavage of procaspase-8 and -3 and poly(ADP-ribose)polymerase into active forms. In addition, in vivo, the administration of 2 to Lewis lung carcinoma-inoculated mice evidenced a significant inhibition of tumor growth (volume) with reduction of 28.7% at concentration of 20 mg/kg, as compared with the control mice.
CONCLUSIONS:
These findings suggest that 2 can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.

Magnaldehyde B Description

Source:	The barks of Magnolia officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	92829-72-6	Price	$413 / 5mg
Catalog No.	CFN95075	Purity	>=98%
Molecular Weight	280.3	Type of Compound	Lignans
Formula	C₁₈H₁₆O₃	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5676 mL	17.838 mL	35.6761 mL	71.3521 mL	89.1902 mL
5 mM	0.7135 mL	3.5676 mL	7.1352 mL	14.2704 mL	17.838 mL
10 mM	0.3568 mL	1.7838 mL	3.5676 mL	7.1352 mL	8.919 mL
50 mM	0.0714 mL	0.3568 mL	0.7135 mL	1.427 mL	1.7838 mL
100 mM	0.0357 mL	0.1784 mL	0.3568 mL	0.7135 mL	0.8919 mL

CFN99449	Isodunnianol	139726-30-0	398.5	C₂₇H₂₆O₃
CFN99448	Dunnianol	139726-29-7	398.5	C₂₇H₂₆O₃
CFN99661	Simonsinol	155709-40-3	398.5	C₂₇H₂₆O₃
CFN96079	Magnolianin	147663-91-0	827.0	C₅₄H₅₀O₈
CFN96188	Magnolignan A	93673-81-5	300.4	C₁₈H₂₀O₄
CFN96189	Magnolignan C	93697-42-8	300.4	C₁₈H₂₀O₄
CFN95076	(1S,2S)-threo-Honokitriol	1099687-80-5	316.4	C₁₈H₂₀O₅
CFN95075	Magnaldehyde B	92829-72-6	280.3	C₁₈H₁₆O₃
CFN96172	Magnaldehyde D	93753-33-4	254.3	C₁₆H₁₄O₃
CFN91033	Tetrahydromagnolol	20601-85-8	270.4	C₁₈H₂₂O₂