ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $49.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Faculty of Chem. & Nat. Resource ...2014...Inflammation.2015, 38(4):1502-16Phytother Res.2016, 30(12):2020-2026Int J Oncol.2016, 49(4):1497-504University of Central Lancashire...2017...Phytomedicine.2017, 24:77-86Cell Physiol Biochem....2017...J Nat Prod.2017, 80(4):854-863
Sci Rep. 2017, 8207(7)Anticancer Res.2018, 38(4):2127-2135Korean J Dent Mater.2018, 45(2):139-146Molecules.2019, 24(17):E3127Exp Biol Med (Maywood)....2019...FASEB J.2019, 33(2):2026-2036Environ Toxicol Pharmacol....2019...Appl. Sci.2020, 10(20),7374.
Front Endocrinol (Lausanne)....2020...Drug Chem Toxicol.2020, 1-14. Research J. Pharm. and Tech....2020...Molecules.2020, 25(23):5556. Food Chem. 2020, 320:126530Korean Herb. Med. Inf....2020...J Korean Soc Food Sci Nutr...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Shanghai Institute of Organic C... (China)Uniwersytet Jagielloński w Kra... (Poland)Universit?t Basel (Switzerland)Gyeongsang National University (Korea)
Universiti Kebangsaan Malaysia (Malaysia)Auburn University (USA)Periyar University (India)University of Madras (India)
Mahatma Gandhi University (India)Kamphaengphet Rajabhat University (Thailand)S.N.D.T. Women's University (India)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Org Biomol Chem.2017, 15(31):6483-6492Biol Pharm Bull.2018, 41(11):1685-1693BioResources J.2020, 15(3).Korean Journal of Pharmacognosy.2019, 50(1):65-71Exp Parasitol.2017, 183:160-166Int J Mol Sci.2020, 21(7):2530.J Agric Food Chem.2015, 63(44):9869-78Plos One.2020, 10.1371Molecules.2019, 24(22):E4022Phytomedicine.2019, 58:152893
Related Screening Libraries
||Demethylsuberosin has potential anti-inflammatory activity, it displays suppressive effects on LPS-induced NO and PGE2 production with the IC50 value of 9.42 uM.|
||NO | PGE|
|Arch Pharm Res. 2016 Feb;39(2):231-9. |
|Constituents of PG201 (Layla(®)), a multi-component phytopharmaceutical, with inhibitory activity on LPS-induced nitric oxide and prostaglandin E2 productions in macrophages.[Pubmed: 26306655]|
|Fourteen compounds, coumarin (1), Demethylsuberosin (2), xanthotoxin (3), psoralen (4), decursinol (5), decursin (6), decursinol angelate (7), chikusetsusaponin IVa (8), chikusetsusaponin IVa methyl ester (9), ethyl caffeate (10), syringaresinol (11), cnidilide (12), farnesol (13), and linoleic acid (14), were isolated from phytopharmaceutical PG201 (Layla(®)) by activity-guided fractionation utilizing inhibitory activity on nitric oxide (NO) production in vitro.
METHODS AND RESULTS:
The isolates 1-14 were evaluated for their inhibitory activity on LPS-induced NO and prostaglandin E2 (PGE2) productions in RAW 264.7 cells. All the compounds except 14 displayed suppressive effects on LPS-induced NO and PGE2 production with IC50 values ranging from 8 to 60 μM. Among these, compound 10 showed the most potent inhibitory effect on NO production from RAW 264.7 cells with an IC50 value of 8.25 μM. Compounds 2, 9, and 10 exhibited high inhibitory effects on PGE2 production with the IC50 values of 9.42, 7.51, and 6.49 μM, respectively.
These findings suggest that compounds 2, 9, and 10 are the potential anti-inflammatory active constituents of PG201 and further study may be needed to explain their mechanism of action.
|J Nat Prod. 2011 Oct 28;74(10):2286-9. |
|Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark.[Pubmed: 21985060]|
|From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark.
METHODS AND RESULTS:
Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (rutarin (3), seselin (4), suberosin (5), Demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7α-obacunyl acetate (11).
The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 μg/mL.
||The roots of Angelica dahuricae
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.