Cannabidivarin | CAS:24274-48-4 | Manufacturer ChemFaces

Cannabidivarin

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Cannabidivarin Description

Source:	The herbs of Cannabis sativa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Br J Pharmacol. 2012 Dec;167(8):1629-42.

Cannabidivarin is anticonvulsant in mouse and rat.[Pubmed: 22970845 ]

Phytocannabinoids in Cannabis sativa have diverse pharmacological targets extending beyond cannabinoid receptors and several exert notable anticonvulsant effects. For the first time, we investigated the anticonvulsant profile of the phytocannabinoid Cannabidivarin (CBDV) in vitro and in in vivo seizure models.
METHODS AND RESULTS:
The effect of CBDV (1-100 μM) on epileptiform local field potentials (LFPs) induced in rat hippocampal brain slices by 4-aminopyridine (4-AP) application or Mg(2+) -free conditions was assessed by in vitro multi-electrode array recordings. Additionally, the anticonvulsant profile of CBDV (50-200 mg·kg(-1) ) in vivo was investigated in four rodent seizure models: maximal electroshock (mES) and audiogenic seizures in mice, and pentylenetetrazole (PTZ) and pilocarpine-induced seizures in rats. The effects of CBDV in combination with commonly used antiepileptic drugs on rat seizures were investigated. Finally, the motor side effect profile of CBDV was investigated using static beam and grip strength assays. CBDV significantly attenuated status epilepticus-like epileptiform LFPs induced by 4-AP and Mg(2+) -free conditions. CBDV had significant anticonvulsant effects on the mES (≥100 mg·kg(-1) ), audiogenic (≥50 mg·kg(-1) ) and PTZ-induced seizures (≥100 mg·kg(-1) ). CBDV (200 mg·kg(-1) ) alone had no effect against pilocarpine-induced seizures, but significantly attenuated these seizures when administered with valproate or phenobarbital at this dose. CBDV had no effect on motor function.
CONCLUSIONS:
These results indicate that CBDV is an effective anticonvulsant in a broad range of seizure models. Also it did not significantly affect normal motor function and, therefore, merits further investigation as a novel anti-epileptic in chronic epilepsy models.

Structure Identification:

International Journal of Pharmacy & Pharmaceutical Sciences, 2014, 6(5):430-433.

In silico screening of phytochemical compounds targeting childhood absence epilepsy (CAE).[Reference: WebLink]

Childhood absence epilepsy (CAE) is the most frequent pediatric epilepsy syndrome. Since, the mechanism of the disease is not well defined, evidence of successful treatment for CAE is not found till date. Hence, an attempt is made to identify novel plant based compounds which may be effective against Pediatric epilepsy syndrome, to meet this demand for newer drugs with minimal side effects.
METHODS AND RESULTS:
We performed a virtual screening of different synthetic compounds/current medications namely ethosuximide, valproic acid, lamotrigine, carbamazepine and vigabatrin were compared against plant derivatives. Cannabidivarin is a potent inhibitor against gamma 2 subunit of GABAA receptors by forming a maximum of number of interactions with the docking score (-5.3).
CONCLUSIONS:
The plant compound Cannabidivarin (CBDV) may serve as a novel drug with definite control over childhood absence epilepsy.

Product Name	Cannabidivarin
Price:
CAS No.:	24274-48-4
Catalog No.:	CFN89253
Molecular Formula:	C₁₉H₂₆O₂
Molecular Weight:	286.41 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Oil
Source:	The herbs of Cannabis sativa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	GABA(A) receptor blockers Compound Library Antiepileptogenic Compound Library Anticonvulsant Compound Library Phenols Compound Library GABA Receptor Inhibitor Library

Description:	Cannabidivarin is a potent inhibitor against gamma 2 subunit of GABAA receptors by forming a maximum of number of interactions with the docking score (-5.3), it may serve as a novel drug with definite control over childhood absence epilepsy. It is also an effective anticonvulsant in a broad range of seizure models.
Targets:	GABA Receptor

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4915 mL	17.4575 mL	34.915 mL	69.83 mL	87.2875 mL
5 mM	0.6983 mL	3.4915 mL	6.983 mL	13.966 mL	17.4575 mL
10 mM	0.3491 mL	1.7457 mL	3.4915 mL	6.983 mL	8.7287 mL
50 mM	0.0698 mL	0.3491 mL	0.6983 mL	1.3966 mL	1.7457 mL
100 mM	0.0349 mL	0.1746 mL	0.3491 mL	0.6983 mL	0.8729 mL

CFN91872	Delta-9-Tetrahydrocannabinolic acid	23978-85-0	358.47	C₂₂H₃₀O₄
CFN91898	Delta-9-Tetrahydrocannabinol	1972-08-3	314.46	C₂₁H₃₀O₂
CFN92993	Cannabinol	521-35-7	310.43	C₂₁H₂₆O₂
CFN92992	Delta-9-Tetrahydrocannabivarinic acid	39986-26-0	330.42	C₂₀H₂₆O₄
CFN89306	Cannabivarin	33745-21-0	282.38	C₁₉H₂₂O₂
CFN96627	Tetrahydrocannabivarin	31262-37-0	286.41	C₁₉H₂₆O₂
CFN89010	10-O-Ethylcannabitriol	1259515-25-7	374.52	C₂₃H₃₄O₄
CFN98793	Rhododendrol	501-96-2	166.2	C₁₀H₁₄O₂
CFN97735	Olivetol	500-66-3	180.24	C₁₁H₁₆O₂
CFN98002	11-Dehydroxygrevilloside B	197307-49-6	342.4	C₁₇H₂₆O₇