ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $8.9 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Scientific World Journal....2014...University of Limpopo2016, 1-237Anal Bioanal Chem. 2016, 408(15)Planta Med.2016, 82(13):1208-16Nat Prod Commun.2017, 12(5):771-778JPC-Journal of Planar Chromatogra...2017...Biol Pharm Bull.2017, 40(6):797-806Molecules.2018, 23(11):E2837
ACS Chem Biol.2019, 14(5):873-881Molecules.2019, 24(20):3755Academic J of Second Military Med...2019...J Funct Foods2019, 54:449-456Phytomedicine.2019, 59:152785Planta Med.2019, 85(9-10):766-773Agronomy2020, 10(10),1489Agronomy2020, 10(3),388.
J of Advanced Scientific R....2020...Front Immunol.2020, 11:598556.Int J Mol Sci.2020, 21(6):2190. J Ethnopharmacol.2020, 254:112733. Korean Journal of Pharmacognosy....2020...Molecules.2021, 26(2):E255.J Nat Med.2021, doi: 10.1007.
Our products had been exported to the following research institutions and universities, And still growing.
Indian Institute of Science (India)Universidad de Buenos Aires (Argentina)University of Wuerzburg (Germany)Universidad de Ciencias y Artes... (Mexico)
Universite Libre de Bruxelles (Belgium)The Australian National University (Australia)Tokyo Woman's Christian University (Japan)Charles Sturt University (Denmark)
Washington State University (USA)Macau University of Science and... (China)Universidade Católica Portuguesa (Portugal)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Ethnopharmacol.2021, 267:113615.Int J Mol Sci.2020, 21(6):2190. J Ethnopharmacol.2017, 196:75-83J Breast Cancer.2015, 18(2):112-118J Herbmed Pharmacol.2018, 7(4):280-286Foods.2020, 9(10):1348. Plos One.2020, 10.1371Molecules.2018, 23(9):E2121Research on Crops.2017, 18(2)Agronomy2020, 10(10),1489
Related Screening Libraries
||Elemicin has anticancer, and antifungal activities, it exhibits anticholinergic-like effects in humans.|
|Chem Res Toxicol. 2012 Nov 19;25(11):2352-67. |
|Physiologically based kinetic models for the alkenylbenzene elemicin in rat and human and possible implications for risk assessment.[Pubmed: 22992039]|
|The present study describes physiologically based kinetic (PBK) models for the alkenylbenzene Elemicin (3,4,5-trimethoxyallylbenzene) in rat and human, based on the PBK models previously developed for the structurally related alkenylbenzenes estragole, methyleugenol, and safrole. |
METHODS AND RESULTS:
Using the newly developed models, the level of metabolic activation of Elemicin in rat and human was predicted to obtain insight in species differences in the bioactivation of Elemicin and read across to the other methoxy allylbenzenes, estragole and methyleugenol. Results reveal that the differences between rat and human in the formation of the proximate carcinogenic metabolite 1'-hydroxyElemicin and the ultimate carcinogenic metabolite 1'-sulfoxyElemicin are limited (<3.8-fold). In addition, a comparison was made between the relative importance of bioactivation for Elemicin and that of estragole and methyleugenol. Model predictions indicate that compound differences in the formation of the 1'-sulfoxymetabolites are limited (<11-fold) in rat and human liver. The insights thus obtained were used to perform a risk assessment for Elemicin using the margin of exposure (MOE) approach and read across to the other methoxy allylbenzene derivatives for which in vivo animal tumor data are available. This reveals that Elemicin poses a lower priority for risk management as compared to its structurally related analogues estragole and methyleugenol.
Altogether, the results obtained indicate that PBK modeling provides an important insight in the occurrence of species differences in the metabolic activation of Elemicin. Moreover, they provide an example of how PBK modeling can facilitate a read across in risk assessment from compounds for which in vivo toxicity studies are available to a compound for which only limited toxicity data have been described, thus contributing to the development of alternatives for animal testing.
||The leaves of Perilla frutescens (L.) Britt.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.