ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Exp Parasitol.2015, 153:160-4International J of Green Pharmacy...2019...Anat Rec (Hoboken)....2021...Industrial Food Engineering...2015...Indian J. of Experimental Bio....2020...J Agric Food Chem.2015, 63(44):9869-78Oxid Med Cell Longev2019, 9056845:13Exp Parasitol.2017, 183:160-166
Neurochem Res.2021, s11064-021-03449-0Journal of Chromatography A2020, 460942J Ethnopharmacol.2020, 254:112733. Evid Based Complement Alternat Me...2021...Int Immunopharmacol.2019, 71:22-31J Agric Food Chem....2021...Vojnosanit Pregl2016, 75(00):391-391Toxicol Rep.2021, 8:1131-1142.
Front Pharmacol.2017, 8:673Korean J Environ Agric....2018...Molecules.2019, 24(20):3755J Phys Chem Lett.2021, 12(7):1793-1802.Evid Based Complement Alternat Me...2017...Evid Based Complement Alternat Me...2021...Trop J Nat Prod Res.2019, 3(1):6-9
Our products had been exported to the following research institutions and universities, And still growing.
Max Rubner-Institut (MRI) (Germany)Monash University Malaysia (Malaysia)Agricultural Research Organizat... (Israel)National Hellenic Research Foun... (Greece)
University of Indonesia (Indonesia)Weizmann Institute of Science (Israel)Ateneo de Manila University (Philippines)University of Ioannina (Greece)
Lund University (Sweden)Instituto de Investigaciones Ag... (Chile)University of Canterbury (New Zealand)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Sustainability2021, 13(23),12981.J Ethnopharmacol.2017, 209:305-316Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83J of Pharmaceutical Analysis2020, doi: 10.1016J Pharmaceut Biomed2020, 182:113110Int J Biol Macromol.2020, 169:342-351Iranian J. Pharm. Res.2021, 20(4):59-70BMC Microbiol.2019, 19(1):78Anticancer Res.2020, 40(10):5529-5538.Heliyon2020, 6(6):e04337.
Related Screening Libraries
||Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lactuca sativa L. (Asteraceae) seedlings in a microassay using 24-well plates. Epiyangambin exhibits significant inhibition of the transformation of murine epidermal JB6 cells, with the IC50 value of 0.15 microg/mL. (+)-Epiyangambin also has anti-platelet aggregation activity. |
|J Nat Prod. 2002 Jul;65(7):1065-8. |
|Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells.[Pubmed: 12141878]|
METHODS AND RESULTS:
Activity-guided fractionation of an ethyl acetate extract of the twigs of Hernandia ovigera, using a soft agar assay with JB6 murine epidermal cells, led to the isolation of two new naturally occurring aryltetralin lignans, (7R,8S,7'R,8'R)-(+)-7'-acetyl-5'-methoxypicropodophyllin (1) and (7R,8S,7'R,8'R)-(+)-7'-acetylpicropodophyllin (2), of which 2 was previously identified as a synthetic product, along with eight known compounds, Epiyangambin (3), caruilignan C, diasesartemin, (+)-epimagnolin A, N-methylcorydaldine, (-)-5'-methoxyyatein, (+)-syringaresinol dimethyl ether, and (-)-yatein. The structures and stereochemistry of 1 and 2 were determined using spectroscopic methods.
Compounds 2 and 3 exhibited significant inhibition of the transformation of murine epidermal JB6 cells, with IC50 values of 0.15 and 0.4 microg/mL, respectively, while the other isolates were regarded as inactive (IC50 >4 microg/mL).
|Nat Toxins. 1999;7(1):39-43. |
|Phytotoxic lignans of Leucophyllum frutescens.[Pubmed: 10441036]|
METHODS AND RESULTS:
Bioassay-guided fractionation of the hexane:ethyl acetate (1:1) extract of the leaves of Leucophyllum frutescens (Berl.) I.M.Johnst (Scrophulariaceae) led to the isolation of its phytotoxic constituents diayangambin (1), Epiyangambin (2), diasesartemin (3) and epiashantin (4). Phytotoxicity was demonstrated as inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lactuca sativa L. (Asteraceae) seedlings in a microassay using 24-well plates. Compound 1 was the most phytotoxic to L. sativa, showing strong inhibitory activity at 110 microM. Compound 1 was more active than 2 and 3 in inhibiting the growth of A. stolonifera with I(50) values of 160, 670 and 930 microM, respectively.
At a concentration of 500 microM, these compounds inhibited all phases of onion root cell division. This is the first demonstration of antimitotic activity of these furofuran lignans, and the first report of their isolation from this species.
||The twigs of Hernandia ovigera.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Planta Med. 2000 Apr;66(3):251-6. |
|Anti-platelet aggregation alkaloids and lignans from Hernandia nymphaeifolia.[Pubmed: 10821052]|
METHODS AND RESULTS:
A new aporphine, N-(N-methylcarbamoyl)-O-methyl-bulbocapnine (1), together with seven known compounds, (-)-5'-methoxypodorhizol (2), a mixture of beta-sitosterone (3) and stigmasta-4,22-dien-3-one (4), a mixture of 3 beta-hydroxystigmast-5-en-7-one (5) and 3 beta-hydroxystigmasta-5,22-dien-7-one (6), and a mixture of 6 alpha-hydroxystigmast-4-en-3-one (7) and 6 alpha-hydroxystigmasta-4,22-dien-3-one (8), were isolated in continuing studies on the trunk bark of Formosan Hernandia nymphaeifolia.
The structures of these compounds were determined through spectral analyses. In addition, the previously reported six alkaloids, laurotetanine, oxohernagine, thalicarpine, reticuline, (+)-vateamine-2'-beta-N-oxide, (+)-hernandaline and six lignans, (+)-epiaschantin, (+)-epimagnolin, (+)-Epiyangambin, (-)-hernone, (-)-yatein, (-)-deoxypodophyllotoxin were demonstrated to have anti-platelet aggregation activity.