ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Orders via your E-mail:
1. Product number / Name / CAS No.
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $5.1 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Br J Pharmacol.2020, 10.1111Foods.2021, 10(12):2929. Antioxidants (Basel).2020, 9(2):E99Int J Mol Sci.2019, 20(21):E5488Biochem Pharmacol.2017, 130:10-20Molecules.2021, 26(3):695. J Ginseng Res.2020, 44(4):611-618.Evid Based Complement Alternat Me...2019...
Research Square2021, 10.21203.Foods.2021, 10(11):2754.Plant Cell Tiss Org2017, 479-486Revista Brasileira de Farmacognos...2021...International J of Green Pharmacy...2019...Nat Prod Commun.2014, 9(5):679-82Natural Product Communications...2020...Int J Mol Sci.2021, 22(16):8604.
J Food Composition and Analysis...2022...Medicinal Chemistry Research ...2021...Biomolecules.2020, 10(6):925.Biomed Chromatogr.2019, 8:e4774Appl. Sci. 2021, 11(22),10569Biomed Pharmacother.2020, 128:110318.Biotechnol Bioeng....2020...
Our products had been exported to the following research institutions and universities, And still growing.
Wroclaw Medical University (Poland)Macau University of Science and... (China)University of Bonn (Germany)Uniwersytet Jagielloński w Kra... (Poland)
Centralised Purchases Unit (CPU... (India)Kazusa DNA Research Institute (Japan)The Vancouver Prostate Centre (... (Canada)Donald Danforth Plant Science C... (USA)
Instituto Politécnico de Bragan?a (Portugal)University of Parma (Italy)Chinese University of Hong Kong (China)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Phytomedicine.2019, 58:152893Nutrients.2019, 12(1)HIV Med.2021, 22(8):690-704.Tumour Biol.2015, 36(9):7027-34Molecules.2021, 26(18):5665.Separations2021, 8(7),90.Mol Neurobiol.2021, 58(8):3665-3676. Int J Mol Sci.2018, 19(9):E2528Appl Biol Chem2019, 62:46Korean Journal of Pharmacognosy.2015, 46(4):352-364
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Alkaloids Compound Library
|| Glycine is an inhibitory transmitter, it may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.|
|Nature,1987 Feb 5-11;325(6104):529-31. |
|Glycine Potentiates the NMDA Response in Cultured Mouse Brain Neurons.[Reference: WebLink]|
|Transmitters mediating 'fast' synaptic processes in the vertebrate central nervous system are commonly placed in two separate categories that are believed to exhibit no interaction at the receptor level. The 'inhibitory transmitters' (such as Glycine and GABA) are considered to act only on receptors mediating a chloride conductance increase, whereas 'excitatory transmitters' (such as L-glutamate) are considered to activate receptors mediating a cationic conductance increase. The best known excitatory receptor is that specifically activated by N-methyl-D-aspartate (NMDA) which has recently been characterized at the single channel level. The response activated by NMDA agonists is unique in that it exhibits a voltage-dependent Mg block.
METHODS AND RESULTS:
We report here that this response exhibits another remarkable property: it is dramatically potentiated by Glycine. This potentiation is not mediated by the inhibitory strychnine-sensitive Glycine receptor, and is detected at a Glycine concentration as low as 10 nM. The potentiation can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
Thus, in addition to its role as an inhibitory transmitter, Glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.
||The seeds of Glycine max (Linn.) Merr.）
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.