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    Natural Products
    Glycine
    Glycine
    Information
    CAS No. 56-40-6 Price $30 / 20mg
    Catalog No.CFN70144Purity>=98%
    Molecular Weight75.0Type of CompoundAlkaloids
    FormulaC2H5NO2Physical DescriptionOil
    Download     COA    MSDSSimilar structuralComparison
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $5.1 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Description: Glycine is an inhibitory transmitter, it may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.
    Targets: NMDA
    In vitro:
    Nature,1987 Feb 5-11;325(6104):529-31.
    Glycine Potentiates the NMDA Response in Cultured Mouse Brain Neurons.[Reference: WebLink]
    Transmitters mediating 'fast' synaptic processes in the vertebrate central nervous system are commonly placed in two separate categories that are believed to exhibit no interaction at the receptor level. The 'inhibitory transmitters' (such as Glycine and GABA) are considered to act only on receptors mediating a chloride conductance increase, whereas 'excitatory transmitters' (such as L-glutamate) are considered to activate receptors mediating a cationic conductance increase. The best known excitatory receptor is that specifically activated by N-methyl-D-aspartate (NMDA) which has recently been characterized at the single channel level. The response activated by NMDA agonists is unique in that it exhibits a voltage-dependent Mg block.
    METHODS AND RESULTS:
    We report here that this response exhibits another remarkable property: it is dramatically potentiated by Glycine. This potentiation is not mediated by the inhibitory strychnine-sensitive Glycine receptor, and is detected at a Glycine concentration as low as 10 nM. The potentiation can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
    CONCLUSIONS:
    Thus, in addition to its role as an inhibitory transmitter, Glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.
    Glycine Description
    Source: The seeds of Glycine max (Linn.) Merr.)
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 13.3333 mL 66.6667 mL 133.3333 mL 266.6667 mL 333.3333 mL
    5 mM 2.6667 mL 13.3333 mL 26.6667 mL 53.3333 mL 66.6667 mL
    10 mM 1.3333 mL 6.6667 mL 13.3333 mL 26.6667 mL 33.3333 mL
    50 mM 0.2667 mL 1.3333 mL 2.6667 mL 5.3333 mL 6.6667 mL
    100 mM 0.1333 mL 0.6667 mL 1.3333 mL 2.6667 mL 3.3333 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.