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Glycine
Glycine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Glycine
Price: $30 / 20mg
CAS No.: 56-40-6
Catalog No.: CFN70144
Molecular Formula: C2H5NO2
Molecular Weight: 75.0 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source: The seeds of Glycine max (Linn.) Merr.)
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $5.1 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Glycine is an inhibitory transmitter, it may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.
Targets: NMDA
In vitro:
Nature,1987 Feb 5-11;325(6104):529-31.
Glycine Potentiates the NMDA Response in Cultured Mouse Brain Neurons.[Reference: WebLink]
Transmitters mediating 'fast' synaptic processes in the vertebrate central nervous system are commonly placed in two separate categories that are believed to exhibit no interaction at the receptor level. The 'inhibitory transmitters' (such as Glycine and GABA) are considered to act only on receptors mediating a chloride conductance increase, whereas 'excitatory transmitters' (such as L-glutamate) are considered to activate receptors mediating a cationic conductance increase. The best known excitatory receptor is that specifically activated by N-methyl-D-aspartate (NMDA) which has recently been characterized at the single channel level. The response activated by NMDA agonists is unique in that it exhibits a voltage-dependent Mg block.
METHODS AND RESULTS:
We report here that this response exhibits another remarkable property: it is dramatically potentiated by Glycine. This potentiation is not mediated by the inhibitory strychnine-sensitive Glycine receptor, and is detected at a Glycine concentration as low as 10 nM. The potentiation can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
CONCLUSIONS:
Thus, in addition to its role as an inhibitory transmitter, Glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.
Glycine Description
Source: The seeds of Glycine max (Linn.) Merr.)
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 13.3333 mL 66.6667 mL 133.3333 mL 266.6667 mL 333.3333 mL
5 mM 2.6667 mL 13.3333 mL 26.6667 mL 53.3333 mL 66.6667 mL
10 mM 1.3333 mL 6.6667 mL 13.3333 mL 26.6667 mL 33.3333 mL
50 mM 0.2667 mL 1.3333 mL 2.6667 mL 5.3333 mL 6.6667 mL
100 mM 0.1333 mL 0.6667 mL 1.3333 mL 2.6667 mL 3.3333 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Berbamine

Catalog No: CFN98727
CAS No: 478-61-5
Price: $50/20mg
gamma-Mangostin

Catalog No: CFN98396
CAS No: 31271-07-5
Price: $70/20mg
8-Shogaol

Catalog No: CFN92299
CAS No: 36700-45-5
Price: $368/20mg
Ganoderic acid K

Catalog No: CFN92057
CAS No: 104700-95-0
Price: $318/5mg
5-Hydroxy-1,7-bis(4-hydroxyphenyl)...

Catalog No: CFN96291
CAS No: 1269839-24-8
Price: $318/10mg
Atractylenolide I

Catalog No: CFN99944
CAS No: 73069-13-3
Price: $70/20mg
Ergosterol peroxide

Catalog No: CFN98035
CAS No: 2061-64-5
Price: $288/10mg
1-O-Acetylbritannilactone

Catalog No: CFN89438
CAS No: 33627-41-7
Price: $218/20mg
Retronecine

Catalog No: CFN00322
CAS No: 480-85-3
Price: $ /
Silybin B

Catalog No: CFN92916
CAS No: 142797-34-0
Price: $368/20mg
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