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    Natural Products
    Heteroclitin D
    Heteroclitin D
    Information
    CAS No. 140369-76-2 Price
    Catalog No.CFN80191Purity>=98%
    Molecular Weight482.19Type of CompoundLignans
    FormulaC27H30O8Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Heteroclitin D

    Heteroclitin D
    Product Name Heteroclitin D
    CAS No.: 140369-76-2
    Catalog No.: CFN80191
    Molecular Formula: C27H30O8
    Molecular Weight: 482.19 g/mol
    Purity: >=98%
    Type of Compound: Lignans
    Physical Desc.: Powder
    Targets: Calcium Channel
    Source: The stems of Kadsura heteroclita
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Lignans Compound Library
  • Calcium Channel Inhibitor Library
  • Biological Activity
    Description: Heteroclitin D may be a valuable antitumor promoter or chemopreventor. Heteroclitin D can inhibit L-type calcium channels.
    Targets: Calcium Channel
    In vitro:
    Acta Pharmacol Sin. 2000 Apr;21(4):373-6.
    Blocking effects of heteroclitin D and gomisin J on L-type calcium channels in ventricular cells of guinea pig.[Pubmed: 11324471]
    To study the effects of Heteroclitin D (HD) and gomisin J (GJ), two lignans from Kadsura medicinal plants, on L-type calcium channels in ventricular cells of guinea pig.
    METHODS AND RESULTS:
    The calcium currents were measured by whole-cell patch-clamp recording technique. HD 1 and 10 mumol/L decreased the L-type calcium current from (770 +/- 155) to (482 +/- 104) and (384 +/- 85) pA, respectively. GJ 10 mumol/L inhibited calcium current from (822 +/- 169) to (436 +/- 143) pA. Neither HD nor GJ affected the steady-state activation curve. But they had impact on steady-state inactivation curve. HD 10 mumol/L changed the half inactivation voltage (V0.5) from -22.7 to -40.9 mV, and slope factor (kappa) from 10.2 to 20.6 (n = 4 cells from 3 guinea pigs, P < 0.05). GJ 10 mumol/L changed the V0.5 from -17.7 to -33.3 mV, and kappa from 15.9 to 27.8 (n = 5 cells from 3 guinea pigs, P < 0.05).
    CONCLUSIONS:
    HD and GJ inhibited L-type calcium channels.
    Heteroclitin D Description
    Source: The stems of Kadsura heteroclita
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0739 mL 10.3694 mL 20.7387 mL 41.4774 mL 51.8468 mL
    5 mM 0.4148 mL 2.0739 mL 4.1477 mL 8.2955 mL 10.3694 mL
    10 mM 0.2074 mL 1.0369 mL 2.0739 mL 4.1477 mL 5.1847 mL
    50 mM 0.0415 mL 0.2074 mL 0.4148 mL 0.8295 mL 1.0369 mL
    100 mM 0.0207 mL 0.1037 mL 0.2074 mL 0.4148 mL 0.5185 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2002 Sep;65(9):1242-5.
    Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.[Pubmed: 12350139]

    METHODS AND RESULTS:
    Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), Heteroclitin D (6), kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds.
    CONCLUSIONS:
    These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.
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