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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $78.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Faculty of Chem. & Nat. Resource ...2014...Br J Pharmacol.2016, 173(2):396-410Bulletin of Health Research...2016...Planta Med.2016, 82(13):1208-16Nat Prod Commun.2017, 12(5):771-778FEMS Microbiol Lett.2017, 364(11)Appl Microbiol Biotechnol....2018...Life Sci.2018, 209:498-506
Cell Biochem Funct.2018, 36(6):303-311Phytomedicine.2018, 47:48-57Biochem Biophys Res Commun....2018...Pharmacol Rep.2018, 70(6):1195-1201Saf Health Work.2019, 10(2):196-204Molecules.2019, 24(16):E3003J of the Korean Society of Food S...2019...Oncol Rep.2019, 41(4):2453-2463
J of Applied Pharmaceutical Scien...2020...Food Analytical Methods2020, 1-10Antioxidants (Basel).2020, 9(2):E120Advances in Traditional Medicine...2020...Front Pharmacol.2020, 11:566490.J Ethnopharmacol.2020, 260:112988.Plants (Basel).2020, 9(11):1422.
Our products had been exported to the following research institutions and universities, And still growing.
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LWT2020, 130:109535Food Chem.2017, 221:1135-1144J Sci Food Agric.2017, 97(5):1656-1662Phytomedicine.2015, 22(14):1262-8United States Patent Application2020, 20200038363Mol Cell.2017, 68(4):673-685Journal of Life Science2018, 917-922Int Immunopharmacol.2020, 90:107268.J Agric Food Chem.2018, 66(1):351-358Front Pharmacol.2020, 11:683.
Related Screening Libraries
||Gelsemine is a highly toxic compound and may be a glycine receptor agonist. Gelsemine has antitumor, anti-hyperlipidemic,anti-oxidative activities,it also has marked antinociception in inflammatory, neuropathic and bone cancer pains without inducing antinociceptive tolerance. |
|J Asian Nat Prod Res. 2010 Sep;12(9):731-9. |
|Antitumor activity of two gelsemine metabolites in rat liver microsomes.[Pubmed: 20839118]|
|Gelsemine is one of the major alkaloids from Gelsemium elegans Benth., which has been used as an antitumor remedy in clinic. |
METHODS AND RESULTS:
In this paper, metabolism of Gelsemine has been investigated in vitro in phenobarbital-treated rat liver microsomes. The metabolites of Gelsemine were separated and evaluated using the flash silica gel column, preparative HPLC, using NMR and MS methods. According to the spectral data, two metabolites, M1 and M2, were identified as 4-N-demethylGelsemine and 21-oxoGelsemine, respectively. By the MTT method in vitro, the antitumor activities between Gelsemine and its metabolites were compared in the HepG2 and HeLa cell lines. Moreover, the main metabolic pathway was further proposed.
|Cell Biochem Biophys. 2015 Jan;71(1):337-44. |
|Anti-hyperlipidemic and anti-oxidative effects of gelsemine in high-fat-diet-fed rabbits.[Pubmed: 25213292]|
|The present study investigated the anti-hyperlipidemic proprieties of a natural alkaloid, Gelsemine, in a high-fat-fed rabbit model. |
METHODS AND RESULTS:
Animals were randomly divided into five groups and fed normal diet, hypercholesterolemic diet (1% cholesterol), or hypercholesterolemic diet (1% cholesterol) supplemented with Gelsemine (1, 5, or 25 mg/kg). After 60 days, serum concentrations of total cholesterol (TC), LDL-C, HDL-C, triglycerides, apolipoproteins A and B, SGOT, SGPT, glucose, and insulin were measured in all experimental groups. Hypercholesterolemic diet resulted in significantly elevated levels of TC, TG, LDL-C, SGOT, and SGPT, and reduced HDL-C compared to the normocholesterolemic diet group. Gelsemine treatment significantly improved lipid profile parameters, affected by hyperlipidemia, while having no effect on the levels of apolipoproteins, glucose, and insulin. Furthermore, Gelsemine treatment decreased hyperlipidemia-induced oxidative stress in a dose-dependent manner, as indicated by the increased activity of superoxide dismutase and catalase, and reduction in serum nitric oxide, and malondialdehyde concentrations in hyperlipidemic animals that received Gelsemine supplementation.
Dietary supplementation with Gelsemine may, therefore, reverse the effect of the lipogenic diet on lipid profile and hepatic enzymes in hyperlipidemic rabbits, and protect tissues from oxidative stress, caused by high-fat diet.
||The root of Gelsemium elegans (Gardn. et Champ.) Benth.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Org Lett. 2008 Nov 6;10(21):4747-50. |
|A concise approach to a gelsemine core structure using an oxygen to carbon bridge swapping strategy.[Pubmed: 18837555]|
|A tricyclic core structure 2 related to Gelsemine 1 was synthesized from an oxabicyclo[3.2.1]octanone 4 by a three-step bridge swapping strategy involving elimination of the bridging ether oxygen and intramolecular Michael addition of a tethered cyanoacetamide unit.|