Homaloside D | CAS:149155-19-1 | Manufacturer ChemFaces

Homaloside D

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Description:

Homaloside D has antiplasmodial activity.

Targets:

Antifection

In vitro:

J Ethnopharmacol. 2010 Jul 20;130(2):272-4.

Antimalarial compounds from the aerial parts of Flacourtia indica (Flacourtiaceae).[Pubmed: 20457242]

In the Comoros Islands, the aerial parts of Flacourtia indica are used in traditional medicine to treat malaria. Because of the important use of this plant, the phytochemistry of the aerial parts was investigated.
METHODS AND RESULTS:
Three compounds were isolated from the decoction of this plant material, pyrocatechol, Homaloside D and poliothrysoside. The in vitro antiplasmodial activity on the chloroquine-resistant strain (W2) of Plasmodium falciparum and the cytotoxicity on two complementary human cell lines (THP1, HepG2), of AcOEt extract obtained after liquid/liquid extraction of the decoction and pure compounds, were evaluated. The poliothrysoside isolated from the AcOEt extract presented a strong antiplasmodial activity (IC(50)=7.4 microM) and a good selectivity index (>28) similar to chloroquine.
CONCLUSIONS:
This study reports for the first time antiplasmodial activity for Flacourtia indica, for its AcOEt extract and the three major constituents and confirms its traditional use.

Homaloside D Description

Source:	The herbs of Gynocardia odorata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Nat Prod. 1993 May;56(5):699-707.

A phytochemical investigation of Homalium ceylanicum.[Pubmed: 8326319]

METHODS AND RESULTS:
Vacciniin [4] (6-O-benzoyl-D-glucopyranoside) and two new benzenoid glucosides, homaloside A [1] (1''-O-benzyl-3''-O-benzoyl-alpha-L-arabinopyranosyl(1'''-->4'')- beta-D-glucopyranoside) and Homaloside D [2] [1-(1'-hydroxy-6'-oxocyclohex-2'-ene-carboxymethyl)- 5-hydroxyphenyl-6''-O-benzoyl-beta-D-glucopyranoside], were isolated from the n-BuOH fraction of Homalium ceylanicum (Flacourtiaceae). A novel cyclohexenone carboxylic acid ester, 1-hydroxy-6-oxocyclohex-2-enoic acid methyl ester [3], was also isolated from this fraction.
CONCLUSIONS:
The structures were elucidated by chemical and nmr (COLOC, FLOCK, and selective INEPT) techniques.

Product Name	Homaloside D
Price:
CAS No.:	149155-19-1
Catalog No.:	CFN99617
Molecular Formula:	C₂₇H₂₈O₁₂
Molecular Weight:	544.5 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Gynocardia odorata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8365 mL	9.1827 mL	18.3655 mL	36.7309 mL	45.9137 mL
5 mM	0.3673 mL	1.8365 mL	3.6731 mL	7.3462 mL	9.1827 mL
10 mM	0.1837 mL	0.9183 mL	1.8365 mL	3.6731 mL	4.5914 mL
50 mM	0.0367 mL	0.1837 mL	0.3673 mL	0.7346 mL	0.9183 mL
100 mM	0.0184 mL	0.0918 mL	0.1837 mL	0.3673 mL	0.4591 mL

CFN95675	Pyrocallianthaside A	1004783-55-4	570.6	C₂₆H₃₄O₁₄
CFN95699	New compound 31	N/A	570.6	C₂₆H₃₄O₁₄
CFN95700	New compound 32	N/A	854.8	C₃₉H₅₀O₂₁
CFN95671	Pyrolaside A	868632-29-5	570.6	C₂₆H₃₄O₁₄
CFN95689	New compound 28	N/A	732.7	C₃₂H₄₄O₁₉
CFN95695	New compound 30	N/A	570.6	C₂₆H₃₄O₁₄
CFN95674	Pyrolaside B	868632-32-0	854.8	C₃₉H₅₀O₂₁
CFN95693	New compound 29	N/A	854.8	C₃₉H₅₀O₂₁
CFN95687	Pyrolaside B analogue	1053610-99-3	854.8	C₃₉H₅₀O₂₁
CFN95688	New compound 27	N/A	870.8	C₃₉H₅₀O₂₂