Apterin | CAS:53947-89-0 | Manufacturer ChemFaces

Apterin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $252.2 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Apterin has anti-inflammatory activity in vitro, it shows significantly inhibitory activity on nitric oxide production in RAW264.7 cells.

Targets:

In vitro:

J Agric Food Chem. 2003 Aug 27;51(18):5255-61.

Antioxidant compounds from the leaves of Peucedanum japonicum thunb.[Pubmed: 12926867 ]

Seventeen compounds were isolated from the n-butanol soluble fraction of the leaves of Peucedanum japonicum Thunb.
METHODS AND RESULTS:
On the basis of MS and various NMR spectroscopic techniques, the structures of the isolated compounds were determined as isoquercitrin (1), rutin (2), 3-O-caffeoylquinic acid (3), 4-O-caffeoylquinic acid (4), 5-O-caffeoylquinic acid (5), cnidioside A (6), praeroside II (7), praeroside III (8), Apterin (9), esculin (10), (R)-peucedanol (11), (R)-peucedanol 7-O-beta-d-glucopyranoside (12), l-tryptophan (13), uracil (14), guanosine (15), uridine (16), and thymidine (17). All compounds except 11 and 12 were isolated for the first time from P. japonicum. Several isolated compounds were quantified by high-performance liquid chromatography analysis. In addition, all isolated compounds were examined for radical scavenging on 1,1-diphenyl-2-picrylhydrazyl radical and for inhibition of oxidation of liposome induced by 2,2'-azobis(2-amidinopropane)dihydrochloride.
CONCLUSIONS:
Compounds 2-5 were found to be the major potent constituents, which contribute to the antioxidant activity of P. japonicum leaves.

In vivo:

Chem Biodivers. 2017 Sep;14(9).

A New Anti-Inflammatory Alkaloid from Roots of Heracleum dissectum.[Pubmed: 28556437 ]

METHODS AND RESULTS:
Using various chromatographic methods, a new piperidinone alkaloid, (3S)-3-{4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenoxy}piperidin-2-one (1), together with 10 known compounds, bergapten (2), xanthotoxol (3), isopimpinellin (4), isobergapten (5), heratomol-6-O-β-d-glucopyranoside (6), scopoletin (7), Apterin (8), 3-methoxy-4-β-d-glucopyranosyloxypropiophenone, (praeroside; 9), tachioside (10) and coniferin (11), were isolated from roots of Heracleum dissectum Ledeb. Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data.
CONCLUSIONS:
All the isolated compounds were screened for anti-inflammatory activity in vitro. As the results, compound 1 and 8 showed significantly inhibitory activity on nitric oxide production in RAW264.7 cells.

Apterin Description

Source:	The herbs of Peucedanum decursivum Maxim.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	53947-89-0	Price	$388 / 10mg
Catalog No.	CFN95005	Purity	>=98%
Molecular Weight	424.4	Type of Compound	Coumarins
Formula	C₂₀H₂₄O₁₀	Physical Description	Powder
Download	COA MSDS SDF	Similar structural	Comparison (Web) (SDF)

Product Name	Apterin
CAS No.:	53947-89-0
Catalog No.:	CFN95005
Molecular Formula:	C₂₀H₂₄O₁₀
Molecular Weight:	424.4 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Targets:	NO
Source:	The herbs of Peucedanum decursivum Maxim.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$388 / 10mg
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Coumarins Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3563 mL	11.7813 mL	23.5627 mL	47.1254 mL	58.9067 mL
5 mM	0.4713 mL	2.3563 mL	4.7125 mL	9.4251 mL	11.7813 mL
10 mM	0.2356 mL	1.1781 mL	2.3563 mL	4.7125 mL	5.8907 mL
50 mM	0.0471 mL	0.2356 mL	0.4713 mL	0.9425 mL	1.1781 mL
100 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.4713 mL	0.5891 mL

CFN90510	Columbianetin acetate	23180-65-6	288.30	C₁₆H₁₆O₅
CFN99785	Columbianadin	5058-13-9	328.36	C₁₉H₂₀O₅
CFN95038	Columbianetin beta-D-glucopyranoside	55836-35-6	408.4	C₂₀H₂₄O₉
CFN95005	Apterin	53947-89-0	424.4	C₂₀H₂₄O₁₀
CFN95272	Peucenidin	33044-93-8	386.4	C₂₁H₂₂O₇
CFN95273	Isoedultin	43043-08-9	386.4	C₂₁H₂₂O₇
CFN95274	9-Hydroxy-O-senecioyl-8,9-dihydrooroselol	31456-63-0	344.4	C₁₉H₂₀O₆
CFN95275	Daucoidin A	103629-87-4	344.4	C₁₉H₂₀O₆
CFN95123	3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol	1221686-60-7	426.5	C₂₄H₂₆O₇
CFN95001	Oroselol	1891-25-4	244.2	C₁₄H₁₂O₄