Inulanolide A | CAS:888941-86-4 | Manufacturer ChemFaces

Inulanolide A

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Description:

Inulanolide A is a novel NFAT1 and MDM2 dual targeting agent and may be a clinical candidate for breast cancer therapy. Inulanolide A has potent cytotoxicity.

Targets:

Mdm2 | p53 | NFAT1

In vitro:

Fitoterapia. 2015 Mar;101:218-23.

Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica.[Pubmed: 25617784]

METHODS AND RESULTS:
Two new sesquiterpene lactone dimers, neojaponicone B (1) and inulanolide E (2) along with five known sesquiterpene lactone dimers (3-7, resp.) were isolated from the aerial parts of Inula japonica Thunb. The chemical structures of 1 and 2 were elucidated by detailed spectroscopic analysis. The relative configuration of 2 was confirmed by biomimetic transformation from the known sesquiterpene lactone dimer Inulanolide A (3). The cytotoxicities of the isolated sesquiterpene lactone dimers were evaluated against 6T-CEM and Jurkat cell lines.
CONCLUSIONS:
All compounds showed potent cytotoxicities with IC50 value of 2.2-5.9μm.

Oncotarget. 2016 May 31;7(22):32566-78.

Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy.[Pubmed: 27105525]

The transcription factor NFAT1 and the oncogene MDM2 have crucial roles in breast cancer development, progression, and metastasis. We have recently discovered that NFAT1 activates MDM2 expression.
METHODS AND RESULTS:
Here, we identified a small molecule (named Inulanolide A) that dually inhibited both NFAT1 and MDM2 in breast cancer cells in vitro and in vivo. Unlike conventional MDM2 inhibitors, Inulanolide A (InuA) exerted its selective anticancer activity in both p53-dependent and -independent manners. InuA decreased cell proliferation and induced G2/M phase arrest and apoptosis in breast cancer cells; it also led to a decrease in MDM2, NFAT1 and proteins associated with cell proliferation, and an increase in apoptotic signal related proteins. In a mouse orthotopic model, JapA suppressed tumor growth and lung metastasis without host toxicity.
CONCLUSIONS:
Thus, InuA is a novel NFAT1 and MDM2 dual targeting agent and may be a clinical candidate for breast cancer therapy. This study also validates the effectiveness of dually targeting NFAT1 and MDM2 in breast cancer.

Inulanolide A Description

Source:	The herbs of Inula japonica Thunb.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Inulanolide A
Price:
CAS No.:	888941-86-4
Catalog No.:	CFN92801
Molecular Formula:	C₃₄H₄₄O₉
Molecular Weight:	596.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Inula japonica Thunb.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Cytotoxic Compound Library Triterpenoids Compound Library p53 Inhibitor Library Mdm2 Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6759 mL	8.3794 mL	16.7588 mL	33.5177 mL	41.8971 mL
5 mM	0.3352 mL	1.6759 mL	3.3518 mL	6.7035 mL	8.3794 mL
10 mM	0.1676 mL	0.8379 mL	1.6759 mL	3.3518 mL	4.1897 mL
50 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.6704 mL	0.8379 mL
100 mM	0.0168 mL	0.0838 mL	0.1676 mL	0.3352 mL	0.419 mL

CFN92708	Japonicone D	1078711-42-8	596.7	C₃₄H₄₄O₉
CFN92801	Inulanolide A	888941-86-4	596.7	C₃₄H₄₄O₉
CFN90168	Absinthiin	1362-42-1	496.62	C₃₀H₄₀O₆
CFN90906	Handelin	62687-22-3	552.7	C₃₂H₄₀O₈
CFN99048	Pre-schisanartanin B	1033288-92-4	590.7	C₃₁H₄₂O₁₁