cis-Mulberroside A | CAS:166734-06-1 | Manufacturer ChemFaces

cis-Mulberroside A

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Description:

cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.

Targets:

TNF-α | NO | NOS

In vivo:

Environ. Toxicol. Pharmacol., 2008,26(3):325-30.

Protective function of cis-mulberroside A and oxyresveratrol from Ramulus mori against ethanol-induced hepatic damage.[Pubmed: 21791383 ]

The aim of the study was to investigate the protective effects of oxyresveratrol and cis-Mulberroside A isolated from Ramulus mori on the liver of mice intoxicated with ethanol.
METHODS AND RESULTS:
Animals were pretreated with different doses (30 and 60mg/kg of body weight) of oxyresveratrol and cis-Mulberroside A prior to the ethanol (9g/kg of body weight) orally for 7 days. Ethanol treatment induced the decrease of reduced glutathione level and antioxidant enzymes activities, the elevation of the lipid peroxidation and cytochrome P450 2E1 activity accompanied with the increase of iron concentration and mitochondrial permeability transition. Pretreatment with oxyresveratrol and cis-Mulberroside A restored the changes in the above parameters up to the basal level. The protective effects of the two active compounds were further supported by attenuation of the degree of tissue damage and the regulation of the expression of TNF-α.
CONCLUSIONS:
It could be concluded that oxyresveratrol and cis-Mulberroside A from R. mori could protect mice against ethanol-induced hepatic damage.

cis-Mulberroside A Description

Source:	The root barks of Morus alba L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Animal Research:

Fitoterapia, 2009, 81(3):214-8.

Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori.[Pubmed: 19755140 ]

This study examined the analgesic and anti-inflammatory actions of cis-Mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice.
METHODS AND RESULTS:
cis-Mulberroside A (25 and 50mg/kg) given by p.o. route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans blue leakage in mice. In addition, this compound exhibited significant systemic anti-inflammatory activity in carrageenan-induced mouse paw edema in a concentration-related manner (33.1-68.5% inhibition), and similar results were achieved in formalin test. Suppressive effects of cis-Mulberroside A on the production of NO and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed. Collectively, cis-Mulberroside A showed high analgesic and anti-inflammatory activities.
CONCLUSIONS:
The above results will be the supporting evidence for the potential anti-rheumatoid activity of R.mori in Chinese traditional medicine.

CAS No.	166734-06-1	Price	$418 / 10mg
Catalog No.	CFN95006	Purity	>=98%
Molecular Weight	568.52	Type of Compound	Phenols
Formula	C₂₆H₃₂O₁₄	Physical Description	Powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	cis-Mulberroside A
CAS No.:	166734-06-1
Catalog No.:	CFN95006
Molecular Formula:	C₂₆H₃₂O₁₄
Molecular Weight:	568.52 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Targets:	TNF-伪 \| NO \| NOS
Source:	The root barks of Morus alba L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$418 / 10mg
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Hepatoprotective Compound Library Analgesia Compound Library Phenols Compound Library TNF-α Inhibitor Library NOS Inhibitor Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.759 mL	8.7948 mL	17.5895 mL	35.1791 mL	43.9738 mL
5 mM	0.3518 mL	1.759 mL	3.5179 mL	7.0358 mL	8.7948 mL
10 mM	0.1759 mL	0.8795 mL	1.759 mL	3.5179 mL	4.3974 mL
50 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.7036 mL	0.8795 mL
100 mM	0.0176 mL	0.0879 mL	0.1759 mL	0.3518 mL	0.4397 mL

CFN90793	Oxyresveratrol 3'-O-beta-D-glucopyranoside	144525-40-6	406.4	C₂₀H₂₂O₉
CFN99586	Mulberroside A	102841-42-9	568.52	C₂₆H₃₂O₁₄
CFN95006	cis-Mulberroside A	166734-06-1	568.52	C₂₆H₃₂O₁₄
CFN92443	Gnetucleistol D	629643-26-1	258.3	C₁₅H₁₄O₄
CFN92425	Gnetol	86361-55-9	244.2	C₁₄H₁₂O₄
CFN92678	Gnetucleistol B	864763-60-0	274.3	C₁₅H₁₄O₅
CFN90811	Salvianolic acid F	158732-59-3	314.3	C₁₇H₁₄O₆
CFN92426	Isorhapotogenin	32507-66-7	258.3	C₁₅H₁₄O₄
CFN97824	Tristin	139101-67-0	260.29	C₁₅H₁₆O₄
CFN92607	Rhapontigenin	500-65-2	258.3	C₁₅H₁₄O₄