ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $50.5 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Asian Journal of Chemistry...2014...Int J Mol Med.2015, 35(5):1237-45Int. Conference on Med. Sci. and ...2017...Journal of Functional Foods...2017...FEMS Microbiol Lett.2017, 364(11)Drug Test Anal.2018, 10(10):1579-1589Nat Prod Sci.2018, 24(2):109-114The Japan Society for Analytical ...2018...
Microb Pathog.2019, 131:128-134Neuropharmacology2019, 151437Chemistry of Plant Materials....2019...Molecules.2019, 24(21):E3834Molecules.2019, 24(23):E4303Food Chem.2019, 276:768-775J Enzyme Inhib Med Chem....2019...J Food Sci Technol....2019...
Anal Biochem.2019, 569:10-15Plos One.2019, 15(2):e0220084Front Pharmacol.2020, 11:683.Toxins (Basel).2020, 12(4):210. Int J Biol Macromol....2020...Food Chem. 2020, 320:126530Eur J Pharmacol.2020, 889:173589.
Our products had been exported to the following research institutions and universities, And still growing.
Johannes Gutenberg University M... (Germany)University of Hertfordshire (United Kingdom)Ain Shams University (Egypt)Max-Planck-Insitut (Germany)
Vin?a Institute of Nuclear Scie... (Serbia)University of Maryland School o... (USA)Research Unit Molecular Epigene... (Germany)Universit?t Basel (Switzerland)
Uniwersytet Jagielloński w Kra... (Poland)Heinrich-Heine-University Düss... (Germany)Universidad de Ciencias y Artes... (Mexico)
Related Screening Libraries
||Isochlorogenic acid A has antiviral, antioxidant, hepatoprotective and potent anti-hepatitis B activities.|
||HBV | HO-1|
|J Ethnopharmacol. 2012 Oct 31;144(1):190-4. |
|Hepatoprotective and antiviral properties of isochlorogenic acid A from Laggera alata against hepatitis B virus infection.[Pubmed: 22982394]|
|The aim of this study was to determine the anti-hepatitis B effect of Isochlorogenic acid A isolated from Laggera alata (Asteraceae), a traditional Chinese herbal medicine.
METHODS AND RESULTS:
The anti-hepatitis B activity of Isochlorogenic acid A was evaluated by the D-galactosamine (D-GalN)-induced HL-7702 hepatocyte damage model and the HBV-transfected HepG2.2.15 cells.
Isochlorogenic acid A significantly improved HL-7702 hepatocyte viability and markedly inhibited the productions of HBsAg and HBeAg. The inhibitory rates of Isochlorogenic acid A on the HBsAg and HBeAg expressions were 86.9% and 72.9%, respectively. In addition, Isochlorogenic acid A declined markedly the content of hepatitis B virus covalently closed circular DNA (HBV cccDNA) and induced significantly the heme oxygenase-1 (HO-1) expression in HepG2.2.15 cells.
Isochlorogenic acid A was verified to possess the potent anti-hepatitis B activity. The anti-HBV target of Isochlorogenic acid A is probably associated with blocking the translation step of the HBV replication. Overexpression of HO-1 may contribute to the anti-HBV activity of Isochlorogenic acid A by reducing the stability of the HBV core protein and thus blocking the refill of nuclear HBV cccDNA. Additionally, the hepatoprotective effect of Isochlorogenic acid A could be achieved by its antioxidative property and induction of HO-1.
Isochlorogenic acid A Description
||The flowerbuds of Lonicera japonica Thunb.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|PLoS One. 2014 Sep 2;9(9):e106254. |
|The activity-integrated method for quality assessment of reduning injection by on-line DPPH-CE-DAD.[Pubmed: 25181475]|
METHODS AND RESULTS:
A sensitive on-line DPPH-CE-DAD method was developed and validated for both screening and determining the concentration of seven antioxidants of Reduning injection. The pH and concentrations of buffer solution, SDS, β-CD and organic modifier were studied for the detection of DPPH and seven antioxidants. By on-line mixing DPPH and sample solution, a DPPH-CE method for testing the antioxidant activity of the complex matrix was successfully established and used to screen the antioxidant components of Reduning injection. Then, antioxidant components including caffeic acid, Isochlorogenic acid A, isochlorogenic acid B, isochlorogenic acid C, chlorogenic acid, neochlorogenic acid and cryptochlorogenic acid were quantified by the newly established CE-DAD method. Finally, the total antioxidant activity and the multiple active components were selected as markers to evaluate the quality of Reduning injection.
The results demonstrated that the on-line DPPH-CE-DAD method was reagent-saving, rapid and feasible for on-line simultaneous determination of total pharmacological activity and contents of multi-components samples. It was also a powerful method for evaluating the quality control and mechanism of action of TCM injection.