Isochlorogenic acid B | CAS:14534-61-3

Isochlorogenic acid B

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $14.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Isochlorogenic acid B Description

Source:	The flowerbud of Lonicera japonica Thunb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

J Biomol Struct Dyn. 2010 Apr;27(5):627-40.

Virtual screening and drug design for PDE-5 receptor from traditional Chinese medicine database.[Pubmed: 20085380]

From docking analyses, Isochlorogenic acid B was identified as the most potential inhibitory compound. De novo evolution designed 47 derivatives. Of the 47 derivatives, seven were able to map into the pharmacophore model, and these seven compounds were suggested to be the most promising leads for inhibiting PDE-5. An analysis of the hydrogen bond interactions formed between the docked ligands and PDE-5 identified ASN662, SER663 and GLN817 as the most frequently interacting residues. A total of eight novel leading compounds were identified to have favorable interaction with PDE-5. These compounds all had hydrogen bond interactions with three key residues that could be further investigated for understanding of PDE-5 and ligands interaction.

Structure Identification:

PLoS One. 2014 Sep 2;9(9):e106254.

The activity-integrated method for quality assessment of reduning injection by on-line DPPH-CE-DAD.[Pubmed: 25181475]

A sensitive on-line DPPH-CE-DAD method was developed and validated for both screening and determining the concentration of seven antioxidants of Reduning injection. The pH and concentrations of buffer solution, SDS, β-CD and organic modifier were studied for the detection of DPPH and seven antioxidants. By on-line mixing DPPH and sample solution, a DPPH-CE method for testing the antioxidant activity of the complex matrix was successfully established and used to screen the antioxidant components of Reduning injection. Then, antioxidant components including caffeic acid, isochlorogenic acid A, Isochlorogenic acid B, isochlorogenic acid C, chlorogenic acid, neochlorogenic acid and cryptochlorogenic acid were quantified by the newly established CE-DAD method.

Product Name	Isochlorogenic acid B
Price:	$50 / 20mg
CAS No.:	14534-61-3
Catalog No.:	CFN99119
Molecular Formula:	C₂₅H₂₄O₁₂
Molecular Weight:	516.45 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	Powder
Source:	The flowerbud of Lonicera japonica Thunb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Phenylpropanoids Compound Library

Description:	Isochlorogenic acid B has antioxidant activity, it is a potential PDE-5 inhibitor.
Targets:	PDE-5

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9363 mL	9.6815 mL	19.363 mL	38.7259 mL	48.4074 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL	7.7452 mL	9.6815 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL	3.8726 mL	4.8407 mL
50 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.7745 mL	0.9681 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.3873 mL	0.4841 mL

CFN99119	Isochlorogenic acid B	14534-61-3	516.45	C₂₅H₂₄O₁₂
CFN91970	Ethyl 3,4-dicaffeoylquinate	143051-73-4	544.50	C₂₇H₂₈O₁₂
CFN90856	3,4-Di-O-caffeoylquinic acid methyl ester	114637-83-1	530.5	C₂₆H₂₆O₁₂
CFN99118	Isochlorogenic acid A	2450-53-5	516.45	C₂₅H₂₄O₁₂
CFN91944	3,5-Dicaffeoyl-epi-quinic acid	879305-14-3	516.45	C₂₅H₂₄O₁₂
CFN90857	3,5-Di-O-caffeoylquinic acid methyl ester	159934-13-1	530.5	C₂₆H₂₆O₁₂
CFN99120	Isochlorogenic acid C	32451-88-0	516.45	C₂₅H₂₄O₁₂
CFN95405	Isochlorogenic acid C 4'-O-glucoside	N/A	678.6	C₃₁H₃₄O₁₇
CFN90858	4,5-Di-O-caffeoylquinic acid methyl ester	188742-80-5	530.5	C₂₆H₂₆O₁₂
CFN90238	3,4,5-Tricaffeoylquinic acid	86632-03-3	678.59	C₃₄H₃₀O₁₅