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1. Reference standards
2. Pharmacological research
3. Inhibitors
Planispine A
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $206.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Sci Rep.2018, 8:15059Food Science&Tech. Res....2022...J Ethnopharmacol.2022, 289:115018. Front Pharmacol.2018, 9:756University of Limpopo2016, 1-237Sci Rep.2021, 11(1):10931.HIV Med.2021, 22(8):690-704.Int J Cosmet Sci....2022...
J Hepatocell Carcinoma....2022...Int J Mol Sci.2018, 19(9):E2681Front Pharmacol.2021, 12:765521.J Ethnopharmacol.2022, 282:114574. Toxicol Res.2019, 35(4):371-387BMC Plant Biol.2020, 20(1):214. Natural Product Communications...2020...J Agric Food Chem....2022...
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Planispine A
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Chinese Pharmacological Bulletin2019, 35(8):1120-1125Comput Biol Chem.2019, 83:107096Antioxidants (Basel).2020, 9(11):1121.J Nat Prod.2021, 84(9):2544-2553.J Cachexia Sarcopenia Muscle.2022, 13(6):3149-3162.Journal of Functional Foods2022, 99: 105331.J Ethnopharmacol.2020, 249:112381Applied Biological Chem. 2020, 26(63).Antioxidants (Basel).2020, 9(6):526.South African J of Botany2020, 135:50-57
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
Planispine A has Anti-inflammatory activity. |
| In vitro: |
| Fitoterapia . 2011 Apr;82(3):347-51 | | Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice[Pubmed: 21059381] | | Zanthoxylum armatum DC. is a traditional Chinese medicine that is prescribed to alleviate pain and treat inflammatory disorders. This species is distributed mainly in the southeast and southwest regions of China. In the present study, we found that ethyl acetate fraction of ethanolic extract of Z. armatum could significantly decrease acetic acid-induced writhing numbers, and suppress formalin induced licking times in the first phase at the highest dose and in the second phase at all tested doses. This observation revealed that Z. armatum extract possessed powerful antinociceptive activity. The mechanisms of the antinociceptive effect might be mainly involved in the periphery inflammatory analgesic. In addition, the ethyl acetate fraction also inhibited xylene-induced ear swelling in a dose-dependent manner in mice. Eight lignans [eudesmin, horsfieldin, fargesin, kobusin, sesamin, asarinin, Planispine A, and pinoresinol-di-3,3-dimethylallyl] were identified as major components of the ethyl acetate fraction. Considering related studies reporting the anti-inflammatory activity for the identified lignans, lignan might be responsible for its anti-inflammatory activity. Our results confirm that the traditional use of Z. armatum in the treatment of inflammation and pain is warranted. |
|
| In vivo: |
| Fitoterapia . 2011 Apr;82(3):347-351. | | Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice[Pubmed: 21059381] | | Zanthoxylum armatum DC. is a traditional Chinese medicine that is prescribed to alleviate pain and treat inflammatory disorders. This species is distributed mainly in the southeast and southwest regions of China. In the present study, we found that ethyl acetate fraction of ethanolic extract of Z. armatum could significantly decrease acetic acid-induced writhing numbers, and suppress formalin induced licking times in the first phase at the highest dose and in the second phase at all tested doses. This observation revealed that Z. armatum extract possessed powerful antinociceptive activity. The mechanisms of the antinociceptive effect might be mainly involved in the periphery inflammatory analgesic. In addition, the ethyl acetate fraction also inhibited xylene-induced ear swelling in a dose-dependent manner in mice. Eight lignans [eudesmin, horsfieldin, fargesin, kobusin, sesamin, asarinin, Planispine A, and pinoresinol-di-3,3-dimethylallyl] were identified as major components of the ethyl acetate fraction. Considering related studies reporting the anti-inflammatory activity for the identified lignans, lignan might be responsible for its anti-inflammatory activity. Our results confirm that the traditional use of Z. armatum in the treatment of inflammation and pain is warranted. |
|
Planispine A Description
| Source: |
The herbs of Coleonema pulchellum |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.2701 mL |
11.3507 mL |
22.7015 mL |
45.403 mL |
56.7537 mL |
| 5 mM |
0.454 mL |
2.2701 mL |
4.5403 mL |
9.0806 mL |
11.3507 mL |
| 10 mM |
0.227 mL |
1.1351 mL |
2.2701 mL |
4.5403 mL |
5.6754 mL |
| 50 mM |
0.0454 mL |
0.227 mL |
0.454 mL |
0.9081 mL |
1.1351 mL |
| 100 mM |
0.0227 mL |
0.1135 mL |
0.227 mL |
0.454 mL |
0.5675 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Nat Prod Res . 2020 Dec 8;1-6. | | Two new lignans from Zanthoxylum armatum[Pubmed: 33289429] | | Zanthoxylum armatum, its peels possessed better special flavour, as well as various bioactivities, such as anti-inflammatory, anti-microbial and anti-tumour. In our chemical investigation on the peels of Z. armatum, two new lignans (1 and 2) and three known lignans (3-5) were isolated by silica gel column chromatography, ODS column and preparative HPLC and their structures were established as zanthlignans A and B (1-2), (-)-asarinin (3), phylligenin (4) and Planispine A (5) through various spectroscopic techniques including UV, IR, HR-ESI-MS, NMR and CD methods. |
|
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