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    Natural Products
    Isofebrifugine
    Isofebrifugine
    Information
    CAS No. 32434-44-9 Price $488 / 20mg
    Catalog No.CFN92303Purity>=98%
    Molecular Weight301.3Type of CompoundAlkaloids
    FormulaC16H19N3O3Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $175.3 / In-stock
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    Isofebrifugine

    Isofebrifugine
    Product Name Isofebrifugine
    CAS No.: 32434-44-9
    Catalog No.: CFN92303
    Molecular Formula: C16H19N3O3
    Molecular Weight: 301.3 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The roots of Dichroa febrifuga
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $488 / 20mg
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  • Anal Bioanal Chem. 2016, 408(15)
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antimalaric Compound Library
  • Alkaloids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Isofebrifugine shows antimalarial activity.
    Targets: Antifection
    In vivo:
    Phytother Res. 2003 Dec;17(10):1234-6.
    Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice.[Pubmed: 14669265]
    The combination effects of chloroquine with a mixture of febrifugine and Isofebrifugine were evaluated against a blood-induced infection with chloroquine-resistant P. berghei NK65 in ICR mice.
    METHODS AND RESULTS:
    Mice in the untreated control showed a progressively increasing parasitemia leading to mouse death. A two-day dosage of 20 mg base/kg of chloroquine alone showed little effect against P. berghei NK65 infection, and all mice died from day 13 to 14 with an increasing parasitemia. A four-day dosage of 1 mg/kg of the febrifugine and Isofebrifugine mixture alone showed a little antimalarial activity, but all mice died from day 19 to 27 with an increasing parasitemia. On the other hand, mice treated with chloroquine plus alkaloids survived during the experiment. All mice treated with chloroquine alone or the alkaloid mixture alone showed low parasitemia levels during a drug administration and following a few days, but then malaria parasites increased in the bloodstream of the treated mice until death. On the other hand, malaria parasites in the mice given chloroquine plus alkaloids decreased on day 6 and then were not detected by a microscopic examination during observation period.
    Journal of Natural Medicines, 2007 , 61 (2) :213-216.
    Seasonal variation in the content of a febrifugine and isofebrifugine alkaloid mixture in aerial parts of Hydrangea macrophylla var. Otaksa, with special reference to its antimalarial activity[Reference: WebLink]
    Febrifugine and Isofebrifugine alkaloid mixtures extracted from the leaves and buds of Hydrangea macrophylla var. Otaksa , collected during different months, in Japan, were quantified using high-performance liquid chromatography.
    METHODS AND RESULTS:
    Leaves collected during the flowering season, namely from June to August, contained 0.16–0.3102mg/g of the alkaloid mixture, whereas those collected from September to December had less than 0.0302mg/g of the mixture. However, extracts of buds harvested from October to February contained a consistently larger amount (more than 0.4902mg/g) of the alkaloids. Hot-water extracts from the leaves and buds collected during different seasons were evaluated for antimalarial activity against Plasmodium yoelii 17XL in mice. The extract of leaves collected in August demonstrated high antimalarial activity, and all mice that received the extract survived the infection. In contrast, the extract of leaves collected in December showed little activity. The extract of buds collected in December cleared parasites, but with subsequent mortality to mouse.
    CONCLUSIONS:
    The present results show that the amount of antimalarial agent—febrifugine and Isofebrifugine mixture—in H. macrophylla var. Otaksa is both part- and season-dependent, suggesting that the choice of plant parts and their harvesting season are important factors worth considering in the pharmacological use of medicinal plants.
    Isofebrifugine Description
    Source: The roots of Dichroa febrifuga
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.319 mL 16.5948 mL 33.1895 mL 66.379 mL 82.9738 mL
    5 mM 0.6638 mL 3.319 mL 6.6379 mL 13.2758 mL 16.5948 mL
    10 mM 0.3319 mL 1.6595 mL 3.319 mL 6.6379 mL 8.2974 mL
    50 mM 0.0664 mL 0.3319 mL 0.6638 mL 1.3276 mL 1.6595 mL
    100 mM 0.0332 mL 0.1659 mL 0.3319 mL 0.6638 mL 0.8297 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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