Jionoside A1 | CAS:120444-60-2 | Manufacturer ChemFaces

Jionoside A1

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $380.8 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Jionoside A1 displays dose dependent immune-enhancement activity and possesses moderate neuroprotective activities on H2O2-treated SH-SY5Y cells.

Targets:

Immunology & Inflammation related

In vitro:

J. Pharm. Biomed. Anal., 2015, 117(6):363-71.

Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC-MS(n) combined with bioassays.[Pubmed: 26433168 ]

Fufang Ejiao Syrup (FES) is a widely used immune-boosting Traditional Chinese Medicine (TCM) in Eastern Asian countries. This study attempts to investigate the bioactive compounds in FES.
METHODS AND RESULTS:
First, FES extract was separated into fractions to facilitate the investigation and 72 compounds were identified using LC-MS(n). Subsequently, Immune-enhancement effects of FES and its components were investigated on bone marrow cells and neuroprotective effects against H2O2 induced oxidative damage were evaluated in SH-SY5Y neuroblastoma cells and bEnd.3. Our results indicated that fraction 3, 5, 6 and 8 showed significant improvements on immune function, while several fractions had cytoprotective effects against H2O2-induced oxidative injury. Jionoside A1 isolated from Radix Rehmanniae Praeparata displayed dose dependent immune-enhancement activity. 20(R)-ginsenoside Rg3 could protect bEnd.3 against oxidative damage. Furthermore, echinacoside, Jionoside A1, vitexin-2-O-rhamnoside, acteoside and isoacteoside possessed moderate protective activities on H2O2-treated SH-SY5Y cells.
CONCLUSIONS:
In conclusion, our study provided both chemical and biological evidences to support clinical application of FES.

Jionoside A1 Description

Source:	The roots of Rehmannia glutinosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Jionoside A1
Price:	$238 / 5mg
CAS No.:	120444-60-2
Catalog No.:	CFN90809
Molecular Formula:	C₃₆H₄₈O₂₀
Molecular Weight:	800.8 g/mol
Purity:	>=98%
Type of Compound:	Polyphenols
Physical Desc.:	Powder
Source:	The roots of Rehmannia glutinosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Immunomodulators Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2488 mL	6.2438 mL	12.4875 mL	24.975 mL	31.2188 mL
5 mM	0.2498 mL	1.2488 mL	2.4975 mL	4.995 mL	6.2438 mL
10 mM	0.1249 mL	0.6244 mL	1.2488 mL	2.4975 mL	3.1219 mL
50 mM	0.025 mL	0.1249 mL	0.2498 mL	0.4995 mL	0.6244 mL
100 mM	0.0125 mL	0.0624 mL	0.1249 mL	0.2498 mL	0.3122 mL

CFN92761	2-Pentadecenedioic acid	81588-35-4	270.4	C₁₅H₂₆O₄
CFN60307	Bay 11-7085	196309-76-9	249.33	C₁₃H₁₅NO₂S
CFN96500	(+/-)-Vestitol	56701-24-7	272.29	C₁₆H₁₆O₄
CFN89045	Eupatolide	6750-25-0	248.32	C₁₅H₂₀O₃