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1. Reference standards
2. Pharmacological research
3. Inhibitors
Kawain
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $46.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Antiviral Res.2013, 98(3):386-93Int. J. of Pha. and Phy. Res....2015...BMC Complement Altern Med.2016, 16:213J Drug Target.2016, 24:1-28J Ethnopharmacol.2017, 197:157-164Korean J of Food Science&Technolo...2017...Sci Rep. 2017, 8207(7)Evid Based Complement Alternat Me...2018...
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Pharmacol Rep.2019, 71(2):289-298Appl. Sci.2020, 10(20), 7323.PLoS One.2020, 15(2):e0220084.J of Applied Biological Chem....2020...Phytomedicine.2020, 79, 153351Korean Herb. Med. Inf....2020...J Ethnopharmacol.2021, 267:113615.
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Kawain
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manager@chemfaces.com
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service@chemfaces.com
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+86-27-84254680
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Molecules.2020, 25(21):5091.J Pharm Biomed Anal.2017, 140:274-280Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.Pharmacogn Mag.2015, 11:S585-91Antioxidants (Basel).2020, 9(6):544. PLoS One.2018, 13(4):e0195642Biomed Chromatogr.2019, 8:e4774J Ethnopharmacol.2017, 209:305-316Eur J Pharmacol.2018, 832:96-103Food Chem.2020, 313:126079
Related Screening Libraries
| Description: |
Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kawain is advanced glycation endproduct inhibitors, can increase the mean life span of Caenorhabditis elegans exposed to high glucose. |
| Targets: |
NMDAR |
| In vitro: |
| Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):697-706. | | Effects of kawain and dihydromethysticin on field potential changes in the hippocampus.[Pubmed: 9194150] | 1. The kava-pyrones Kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties.
METHODS AND RESULTS:
3. Kawain and dihydromethysticin reduced reversibly the frequency of occurrence of fp in a concentration range from 5 to 40 mumol/l and 10 to 40 mumol/l, respectively. 4. Reduction of the fp frequency after addition of subthreshold concentrations of 5 mumol/l Kawain and 10 mumol/l dihydromethysticin indicated additive actions of both drugs. 5. Since the serotonin-1A agonist ipsapirone also exerts anxiolytic effects, subthreshold concentrations of Kawain or dihydromethysticin were combined with a subthreshold concentration of ipsapirone in another set of experiments. Combining Kawain and ipsapirone or dihydromethysticin and ipsapirone caused a reduction of the rate of fp to 0.76 and 0.81 of the baseline value, respectively.
CONCLUSIONS:
6. The findings suggest that (i) single constituents of Piper methysticum may have additive actions, (ii) that the two components Kawain and dihydromethysticin may enhance the effects of the anxiolytic serotonin-1A agonist ipsapirone and (iii) that activation of NMDA receptors and/or voltage dependent calcium channels may be involved in the elementary mechanism of action of some kava-pyrones. |
|
| In vivo: |
| Drug Metab Dispos. 2005 Oct;33(10):1555-63. | | Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro.[Pubmed: 16033948] |
METHODS AND RESULTS:
The oral pharmacokinetics of the kavalactone, Kawain (100 mg/kg), were determined in rats with and without coadministration of kava extract (256 mg/kg) to study the effect of the extract on drug disposition. Kawain was well absorbed, with >90% of the dose eliminated within 72 h, chiefly in urine. Compared with Kawain alone, coadministration with kava extract caused a tripling of Kawain AUC(0-8 h) and a doubling of C(max). However, a 7-day pretreatment with kava extract (256 mg /kg/day) had no effect on the pharmacokinetics of Kawain administered on day 8.
CONCLUSIONS:
The 7-day pretreatment with kava extract only modestly induced hepatic P450 activities. |
|
Kawain Description
| Source: |
The roots of Piper methysticum Forst |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
4.3422 mL |
21.7108 mL |
43.4216 mL |
86.8432 mL |
108.5541 mL |
| 5 mM |
0.8684 mL |
4.3422 mL |
8.6843 mL |
17.3686 mL |
21.7108 mL |
| 10 mM |
0.4342 mL |
2.1711 mL |
4.3422 mL |
8.6843 mL |
10.8554 mL |
| 50 mM |
0.0868 mL |
0.4342 mL |
0.8684 mL |
1.7369 mL |
2.1711 mL |
| 100 mM |
0.0434 mL |
0.2171 mL |
0.4342 mL |
0.8684 mL |
1.0855 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Kinase Assay: |
| Planta Med. 2014 Aug;80(12):1001-8. | | Kavalactones, a novel class of protein glycation and lipid peroxidation inhibitors.[Pubmed: 25098935] | Kawain, methysticin, and dihydromethysticin, all belonging to the group of kavalactones, were identified as advanced glycation endproduct inhibitors.
METHODS AND RESULTS:
With IC50 values of 43.5 ± 1.2 μM and 45.0 ± 1.3 μM for Kawain and methysticin, respectively, the compounds inhibited the in vitro protein glycation significantly better than aminoguanidine (IC50 = 231.0 ± 11.5 μM; p = 0.01), an established reference compound. Kawain and methysticin also inhibited the formation of dicarbonyl compounds, which are intermediates in the process of advanced glycation endproduct formation.
CONCLUSIONS:
Similarly, Kawain and aminoguanidine prevented the formation of thiobarbituric reactive substances in both low-density lipoprotein and linoleic acid oxidation. Moreover, Kawain and aminoguanidine prevented advanced glycation endproduct formation by chelating Fe(3+) and Cu(2+) two to three times better than aminoguanidine. Furthermore, Kawain increased the mean life span of Caenorhabditis elegans exposed to high glucose. |
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