Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Polyporenic acid C
    Information
    CAS No. 465-18-9 Price $338 / 5mg
    Catalog No.CFN92739Purity>=98%
    Molecular Weight482.7Type of CompoundTriterpenoids
    FormulaC31H46O4Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $338 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Periyar University (India)
  • University of Madras (India)
  • University of Maryland School o... (USA)
  • University of Canterbury (New Zealand)
  • Universiti Sains Malaysia (Malaysia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Hertfordshire (United Kingdom)
  • University of Pretoria (South Africa)
  • Washington State University (USA)
  • Cancer Research Initatives Foun... (Malaysia)
  • Deutsches Krebsforschungszentrum (Germany)
  • More...
  • Package
    Featured Products
    Kaempferol 3-O-(6''-galloyl)-beta-...

    Catalog No: CFN92383
    CAS No: 56317-05-6
    Price: $533/5mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $368/5mg
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg
    Tenuifoliside A

    Catalog No: CFN90770
    CAS No: 139726-35-5
    Price: $278/20mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg
    Chrysosplenol D

    Catalog No: CFN99622
    CAS No: 14965-20-9
    Price: $268/10mg
    Deapi-platycoside E

    Catalog No: CFN92355
    CAS No: 849758-42-5
    Price: $268/5mg

    Polyporenic acid C

    Polyporenic acid C
    Product Name Polyporenic acid C
    CAS No.: 465-18-9
    Catalog No.: CFN92739
    Molecular Formula: C31H46O4
    Molecular Weight: 482.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: PARP | Caspase | PI3K | Akt | p53
    Source: The roots of Wolfiporia cocos (Schw.) Ryv.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $338 / 5mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Nat Prod Sci.2019, 25(3):238
  • Phytomedicine.2021, 2(82):153452
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Pharmacol Rep.2020, 72(2):472-480.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • J Pharmaceut Biomed2020, 178:112894
  • Toxicological Research2020, doi: 10.1007.
  • Industrial Food Engineering2015, 19(4):408-413
  • Molecules.2017, 22(3)
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticancer Compound Library
  • Antibacterial Compound Library
  • Triterpenoids Compound Library
  • PI3K Inhibitor Library
  • PARP Inhibitor Library
  • p53 Inhibitor Library
  • Caspase Inhibitor Library
  • Akt Inhibitor Library
  • Biological Activity
    Description: Polyporenic acid C shows inhibitory activity against human collagenase. Polyporenic acid C induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria.
    Targets: PARP | Caspase | PI3K | Akt | p53
    In vitro:
    Mol Carcinog. 2009 Jun;48(6):498-507.
    Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.[Pubmed: 18973184]
    Lung cancer continues to be the leading cause of cancer-related mortality worldwide. This warrants the search for new and effective agents against lung cancer. We and others have recently shown that lanostane-type triterpenoids isolated from the fungal species Poria cocos (P. cocos) can inhibit cancer growth. However, the mechanisms responsible for the anticancer effects of these triterpenoids remain unclear.
    METHODS AND RESULTS:
    In this study, we investigated the effect of Polyporenic acid C (PPAC), a lanostane-type triterpenoid from P. cocos, on the growth of A549 nonsmall cell lung cancer cells (NSCLC). The results demonstrate that PPAC significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with PPAC was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, PPC-induced apoptosis was inhibited by caspase-8 and pan caspase inhibitors but not by a caspase-9 inhibitor. Taken together, the results suggest that PPAC induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria. Furthermore, suppressed PI3-kinase/Akt signal pathway and enhanced p53 activation after PPAC treatment suggests this to be an additional mechanism for apoptosis induction.
    CONCLUSIONS:
    Together, these results encourage further studies of PPAC as a promising candidate for lung cancer therapy.
    Polyporenic acid C Description
    Source: The roots of Wolfiporia cocos (Schw.) Ryv.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Securoside A

    Catalog No: CFN95294
    CAS No: 107172-40-7
    Price: $318/5mg
    Genistein 7-O-beta-D-glucopyranosi...

    Catalog No: CFN95159
    CAS No: 70404-42-1
    Price: $318/10mg
    Saucerneol

    Catalog No: CFN95267
    CAS No: 88497-86-3
    Price: $413/5mg
    Deoxy euphorbia factor L1

    Catalog No: CFN95340
    CAS No: 247099-01-0
    Price: $318/10mg
    Apigenin 7-O-(6''-O-malonylglucosi...

    Catalog No: CFN95163
    CAS No: 86546-87-4
    Price: $318/5mg
    Pueroside C

    Catalog No: CFN95156
    CAS No: 112343-16-5
    Price: $368/5mg
    Suchilactone

    Catalog No: CFN95010
    CAS No: 50816-74-5
    Price: $338/5mg
    1,3,6-Trihydroxy-2-methylanthraqui...

    Catalog No: CFN95096
    CAS No: 87686-88-2
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0717 mL 10.3584 mL 20.7168 mL 41.4336 mL 51.792 mL
    5 mM 0.4143 mL 2.0717 mL 4.1434 mL 8.2867 mL 10.3584 mL
    10 mM 0.2072 mL 1.0358 mL 2.0717 mL 4.1434 mL 5.1792 mL
    50 mM 0.0414 mL 0.2072 mL 0.4143 mL 0.8287 mL 1.0358 mL
    100 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.4143 mL 0.5179 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Kaempferol 3-O-(6''-galloyl)-beta-...

    Catalog No: CFN92383
    CAS No: 56317-05-6
    Price: $533/5mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $368/5mg
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg
    Tenuifoliside A

    Catalog No: CFN90770
    CAS No: 139726-35-5
    Price: $278/20mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg
    Chrysosplenol D

    Catalog No: CFN99622
    CAS No: 14965-20-9
    Price: $268/10mg
    Deapi-platycoside E

    Catalog No: CFN92355
    CAS No: 849758-42-5
    Price: $268/5mg