ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules. 2013, 18(11):14105-21J-STAGE2015, 249-255University of Limpopo2016, 1777The Korea Journal of Herbology...2016...J Ethnopharmacol.2017, 206:327-336LWT-Food Science and Technology...2017...Sci Rep. 2017, 8207(7)Korean J. Medicinal Crop Sci....2018...
J Sep Sci.2018, 41(11):2488-2497J of Health Science and Alternati...2019...Nat Commun.2019, 10(1):2745J Med Food.2019, 22(10):1067-1077Chem Biol Interact.2019, 315:108910Phytother Res.2019, 33(3):676-689Environ Toxicol.2019, 34(4):513-520.Journal of Functional Foods...2019...
J Agric Food Chem....2019...Research J. Pharm. and Tech....2020...BioResources J.2020, 15(3).Molecules.2020, 25(9):2081.Molecules.2020, 25(9):2111.Korean J Dent Mater2020, 47(2):63-70.Natural Product Communications...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Julius Kühn-Institut (Germany)University of Dicle (Turkey)Nicolaus Copernicus Uniwersity (Poland)Medical University of Gdansk (Poland)
Kamphaengphet Rajabhat University (Thailand)MTT Agrifood Research Finland (Finland)Universidade da Beira Interior (Germany)Colorado State University (USA)
Max-Planck-Insitut (Germany)Washington State University (USA)University of Amsterdam (Netherlands)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Pharmacol Res.2020, 161:105205.Neurotox Res.2020, 38(1):163-174.Sci Rep.2019, 9(1):4646Appl Biochem Biotechnol.2020, 190(2):732-744The Malaysian journal of pathology2019, 41(3):243-251Oncol Rep.2019, 41(4):2453-2463Cell.2018, 172(1-2):249-261Front Immunol. 2020, 11:62.Metabolites.2020, 10(12):497.Korean Journal of Pharmacognosy2014, 113-120
Related Screening Libraries
|| Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.|
||PARP | Caspase|
Kuguaglycoside C Description
||The fruits of Momordica charantia
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Cancer Sci. 2012 Dec;103(12):2153-8. |
|Kuguaglycoside C, a constituent of Momordica charantia, induces caspase-independent cell death of neuroblastoma cells.[Pubmed: 22957888]|
|Kuguaglycoside C is a triterpene glycoside isolated from the leaves of Momordica charantia, and the biological effects of this compound remain almost unknown. |
METHODS AND RESULTS:
We investigated the anti-cancer effect of Kuguaglycoside C against human neuroblastoma IMR-32 cells. In the MTT assay, Kuguaglycoside C induced significant cytotoxicity against the IMR-32 cells (IC(50) : 12.6 μM) after 48 h treatment. Although examination by Hoechst 33342 staining revealed that Kuguaglycoside C induced nuclear shrinkage at a high concentration (100 μM), no apoptotic bodies were observed on flow cytometry. No activation of caspase-3 or caspase-9 was observed at the effective concentration (30 μM) of Kuguaglycoside C. On the other hand, the substance significantly decreased the expression of survivin and cleaved poly (ADP-ribose) polymerase (PARP). Kuguaglycoside C also significantly increased the expression and cleavage of apoptosis-inducing factor (AIF). Moreover, Kuguaglycoside C was found to induce caspase-independent DNA cleavage in the dual-fluorescence apoptosis detection assay.
These results suggest that Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.