ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
L-Glutamine
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: info@chemfaces.com
Contact Us
Order & Inquiry & Tech Support
Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
E-mail: manager@chemfaces.com
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery time
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $7.0 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Molecules.2021, 26(4):816. Int J Mol Sci.2021, 22(12):6466.Nutrients2022, 14(3),695.Phytother Res.2022, ptr.7573.Int J Mol Sci.2022, 23(11):6104. Phytomedicine.2022, 100:154058.Indian J Pharm Sci.2022, 84(3):144-151Tissue Cell.2022, 75:101728.
Invest New Drugs.2017, 35(2):166-179J Pharmaceut Biomed2020, 182:113110J Pharm Pharmacol.2022, rgac033. Sains Malaysiana2022, 51(4):1143-1154Food Chem.2017, 228:301-314Saudi Pharm J.2019, 27(1):145-153Phytomedicine.2018, 38:45-56J Biochem Mol Toxicol....2021...
Evid Based Complement Alternat Me...2019...Nutrients.2020, 12(11):3448. J Anal Toxicol.2021, bkab015.Molecules.2019, 24(21):E3834Semyung University2017, 149407Molecules.2021, 26(6):1635. Int J Mol Sci.2019, 20(8):E1855
More...
Our products had been exported to the following research institutions and universities, And still growing.
University of Madras (India)Sanford Burnham Medical Researc... (USA)The Australian National University (Australia)Charles University in Prague (Czech Republic)
Deutsches Krebsforschungszentrum (Germany)Universidade Federal de Santa C... (Brazil)Yale University (USA)The Ohio State University (USA)
University of Liège (Belgium)Chulalongkorn University (Thailand)Celltrion Chemical Research Ins... (Korea)
More...
L-Glutamine
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Journal of Life Science2018, 917-922Reprod Sci.2022,10.1007/s43032-022-01117-4.Phytomedicine2022, 104:154318Molecules.2019, 24(6):E1177J Ethnopharmacol.2019, 244:112074J of Engineering Science&Technology2018, 13(9):2820-2828Molecules.2019, 24(19):E3417Journal of Chromatography A2020, 460942Plant J.2021, 107(6):1711-1723.Int J Mol Sci.2021, 22(21):11447.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
L-Glutamine prevents acetaldehyde-induced disruption of the tight junction and increase in the paracellular permeability in Caco-2 cell monolayer by an EGF receptor-dependent mechanism. It prevents oxidant- or endotoxin-induced death of neonatal enterocytes. |
| Targets: |
EGFR |
| In vitro: |
| American Journal of physiology. Gastrointestinal and Liver Physiology, 01 Sep 2004, 287(3):G510-7。 | | L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer.[Reference: WebLink] |
METHODS AND RESULTS:
Role of L-Glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function was evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a time- and dose-dependent manner; d-glutamine, L-aspargine, L-arginine, L-lysine, or L-alanine produced no significant protection. The glutaminase inhibitor 6-diazo-5-oxo-L-norleucine failed to affect the L-Glutamine-mediated protection of barrier function. L-Glutamine reduced the acetaldehyde-induced redistribution of occludin, zonula occludens-1 (ZO-1), E-cadherin, and beta-catenin from the intercellular junctions. Acetaldehyde dissociates occludin, ZO-1, E-cadherin, and beta-catenin from the actin cytoskeleton, and this effect was reduced by L-Glutamine. L-Glutamine induced a rapid increase in the tyrosine phosphorylation of EGF receptor, and the protective effect of L-Glutamine was prevented by AG1478, the EGF-receptor tyrosine kinase inhibitor.
CONCLUSIONS:
These results indicate that L-Glutamine prevents acetaldehyde-induced disruption of the tight junction and increase in the paracellular permeability in Caco-2 cell monolayer by an EGF receptor-dependent mechanism. | | Diabetologia, 1981, 63(2):112-118. | | The stimulus-secretion coupling of amino acid-induced insulin release. IV. Ionic response to L-Leucine and L-Glutamine.[Reference: WebLink] |
METHODS AND RESULTS:
L-Glutamine enhances insulin release evoked by L-leucine in isolated rat pancreatic islets. The enhancing action of L-Glutamine, which is a rapid but steadily increasing and not rapidly reversible phenomenon is not attributable to any major change in either K+ or Ca2+ outflow from the islet cells. It coincides with an apparent increase in Ca2+ inflow rate and, hence, with Ca accumulation in the islets. The initial ionic response to L-leucine is not qualitatively altered by the presence of L-Glutamine. In their combined capacity to stimulate 45Ca net uptake in the islets, L-Glutamine can be replaced by L-asparagine but not by L-glutamate, whereas L-leucine can be replaced by L-norvaline or L-isoleucine, but not by L-valine, glycine or L-lysine. Such a specificity is identical to that characterizing the effect of these various amino acids upon insulin release.
CONCLUSIONS:
It is postulated that the release of insulin evoked by the combination of L-leucine and L-Glutamine involves essentially the same remodelling of ionic fluxes as that evoked by other nutrient secretagogues with, however, an unusual time course for the functional response to L-Glutamine. |
|
L-Glutamine Description
| Source: |
The culture product of Escherichia coli. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
6.8446 mL |
34.2231 mL |
68.4463 mL |
136.8925 mL |
171.1157 mL |
| 5 mM |
1.3689 mL |
6.8446 mL |
13.6893 mL |
27.3785 mL |
34.2231 mL |
| 10 mM |
0.6845 mL |
3.4223 mL |
6.8446 mL |
13.6893 mL |
17.1116 mL |
| 50 mM |
0.1369 mL |
0.6845 mL |
1.3689 mL |
2.7379 mL |
3.4223 mL |
| 100 mM |
0.0684 mL |
0.3422 mL |
0.6845 mL |
1.3689 mL |
1.7112 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Animal Research: |
| Amino Acids, 2009, 37(1):131-142. | | L-Glutamine or L-alanyl-L-glutamine prevents oxidant- or endotoxin-induced death of neonatal enterocytes.[Reference: WebLink] | This study tested the hypothesis that L-Glutamine (Gln) or L-alanyl-L-Glutamine (Ala-Gln) prevents oxidant- or endotoxin-induced death of neonatal enterocytes. Enterocytes of neonatal pigs rapidly hydrolyzed Ala-Gln and utilized Gln.
METHODS AND RESULTS:
To determine whether Gln or Ala-Gln has a cytoprotective effect, IPEC-1 cells were cultured for 24 h in Gln-free Dulbecco’s modified Eagle’s-F12 Ham medium containing 0, 0.5, 2.0 or 5.0 mM Gln or Ala-Gln, and 0, 0.5 mM H2O2 or 30 ng/ml lipopolysaccharide (LPS). Without Gln or Ala-Gln, H2O2- or LPS-treated cells exhibited almost complete death. Gln or Ala-Gln at 0.5, 2 and 5 mM dose-dependently reduced H2O2- or LPS-induced cell death by 14, 54 and 95%, respectively, whereas D-glutamine, alanine, glutamate, ornithine, proline, glucosamine or nucleosides had no effect. To evaluate the effectiveness of Gln or Ala-Gln in vivo, 7-day-old piglets received one-week oral administration of Gln or Ala-Gln (3.42 mmol/kg body weight) twice daily and then a single intraperitoneal injection of LPS (0.1 mg/kg body weight); piglets were euthanized in 24 and 48 h to analyze intestinal apoptotic proteins and morphology. Administration of Gln or Ala-Gln to LPS-challenged piglets increased Gln concentrations in small-intestinal lumen and plasma, reduced intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorated intestinal injury, decreased rectal temperature, and enhanced growth performance. These results demonstrate a protective effect of Gln or Ala-Gln against H2O2- or LPS-induced enterocyte death.
CONCLUSIONS:
The findings support addition of Gln or Ala-Gln to current Gln-free pediatric amino acid solutions to prevent intestinal oxidative injury and inflammatory disease in neonates. |
|
Tags: buy L-Glutamine | L-Glutamine supplier | purchase L-Glutamine | L-Glutamine cost | L-Glutamine manufacturer | order L-Glutamine | L-Glutamine distributor
