Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Labd-13-ene-8,15-diol
    Information
    CAS No. 10267-31-9 Price
    Catalog No.CFN99042Purity>=98%
    Molecular Weight308.5 Type of CompoundDiterpenoids
    FormulaC20H36O2Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Cornell University (USA)
  • University of Bonn (Germany)
  • Washington State University (USA)
  • University of Sao Paulo (Brazil)
  • Heinrich-Heine-University Düss... (Germany)
  • Center for protein Engineering ... (Belgium)
  • Universidad Industrial de Santa... (Colombia)
  • University of Brasilia (Brazil)
  • Auburn University (USA)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Uniwersytet Gdański (Poland)
  • More...
  • Package
    Featured Products
    Syringaresinol-di-O-glucoside

    Catalog No: CFN90458
    CAS No: 66791-77-3
    Price: $188/20mg
    Przewalskin

    Catalog No: CFN99306
    CAS No: 119400-87-2
    Price: $398/5mg
    Ginsenoside Compound K

    Catalog No: CFN99756
    CAS No: 39262-14-1
    Price: $100/20mg
    20R-Ginsenoside Rg2

    Catalog No: CFN90412
    CAS No: 80952-72-3
    Price: $298/20mg
    Echinacoside

    Catalog No: CFN98105
    CAS No: 82854-37-3
    Price: $60/20mg
    Picroside III

    Catalog No: CFN99567
    CAS No: 64461-95-6
    Price: $228/20mg
    Linderalactone

    Catalog No: CFN99761
    CAS No: 728-61-0
    Price: $198/20mg

    Labd-13-ene-8,15-diol

    Labd-13-ene-8,15-diol
    Product Name Labd-13-ene-8,15-diol
    CAS No.: 10267-31-9
    Catalog No.: CFN99042
    Molecular Formula: C20H36O2
    Molecular Weight: 308.5 g/mol
    Purity: >=98%
    Type of Compound: Diterpenoids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The fruits of Ziziphus jujuba
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Int J Anal Chem.2017, 2017:1254721
  • Mol Med Rep.2014, 9(5):1653-9
  • Pharmacol Rep.2019, 71(2):289-298
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • J Ethnopharmacol.2016, 192:370-381
  • Korean J Environ Agric.2018, 37(4):260-267
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • J Pharm Biomed Anal.2018, 151:32-41
  • Analytical Letters.2020, doi 10.1008
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticancer Compound Library
  • Antibacterial Compound Library
  • Antiviral Compound Library
  • Diterpenoids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: 13(E)-Labd-13-ene-8alpha,15-diol shows antiviral and anticancer activity, it shows strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 microg/mL,respectively; it also exhibits antilung and antilaryngeal cancer activities against A549 and Hep2 cells.13(E)-Labd-13-ene-8α,15-diol inhibits the growth of the gram-positive bacteria (Staphylococcus aureus, Bacillus cereus and Listeria monocytogenes) and gram-negative bacteria (Vibrio parahaemolyticus, Escherichia coli and Salmonella enteritidis) with a range of minimum inhibitory concentration (MIC) values from 0.092 to 0.598 mg/mL and gram-negative bacteria are more sensitive to the compound (MIC, 0.092 mg/mL).
    Targets: Antifection
    In vitro:
    Phytother. Res.,2010 Feb;24(2):169-74.
    Antiviral and anticancer activities of 13(E)-labd-13-ene-8alpha,15-diol isolated from Brachyglottis monroi.[Pubmed: 19504469 ]

    METHODS AND RESULTS:
    The antiviral activity of 13(E)-labd-13-ene-8alpha,15-diol (Labd-13-ene-8,15-diol,1), isolated from Brachyglottis monroi, was examined against human rhinovirus 2 (HRV2) and 3 (HRV3), and the anticancer activity on human cancer cells (A549 and Hep2). Compound (1) showed strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC(50)) of 2.68 and 0.87 microg/mL, respectively, and a 50% cytotoxicity concentration (CC(50)) of 59.45 microg/mL. Ribavirin only showed anti-HRV3 activity with an IC(50) of 30.48 microg/mL and a CC(50) > 100 microg/mL. The addition of compound (1) to HRV-infected HeLa cells directly reduced the formation of visible cytopathic effect (CPE) and it directly interacted with HRV particles. Furthermore, A549 and Hep2 cells incubated with 32 microg/mL of compound (1) for 48 h exhibited antilung and antilaryngeal cancer activities, with a viability of less than 50%.
    CONCLUSIONS:
    These results suggest that compound (1) may be used as a potential antiviral and anticancer agent.
    J. Appl. Biol. Chem.,2013, 56(1):581-90.
    Anticancer and Antimicrobial Activities of 13(E)-labd-13-ene-8α,15-diol from Brachyglottis monroi[Reference: WebLink]
    In a previous study, we reported that 13(E)-labd-13- ene-8α, 15-diol (Labd-13-ene-8,15-diol ,13E) possesses antiviral and anticancer activities.
    METHODS AND RESULTS:
    In this study, the anticancer and antimicrobial activities of 13(E) were evaluated against 4 cancer cell lines and 6 bacteria. 13(E) showed inhibitory effect on a variety of cancer cell lines. The IC50 values was 8.3-21.3 μg/mL. 13(E) was the most effective growth inhibitor of murine leukaemia cell lines P388, producing approximately 8.3 μg/mL of IC50 in the cytopathic effect (CPE) method. 13(E) also inhibited the growth of the gram-positive bacteria (Staphyl℃℃cus aureus, Bacillus cereus and Listeria mon℃ytogenes) and gram-negative bacteria (Vibrio parahaemolyticus, Escherichia coli and Salmonella enteritidis) with a range of minimum inhibitory concentration (MIC) values from 0.092 to 0.598 mg/mL and gram-negative bacteria were more sensitive to the compound (MIC, 0.092 mg/mL).
    Labd-13-ene-8,15-diol Description
    Source: The fruits of Ziziphus jujuba
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    6''-O-acetylsaikosaponin A

    Catalog No: CFN95086
    CAS No: 64340-46-1
    Price: $268/10mg
    Silychristin B

    Catalog No: CFN95160
    CAS No: 879325-58-3
    Price: $318/5mg
    Methylenetanshinquinone

    Catalog No: CFN92179
    CAS No: 67656-29-5
    Price: $338/5mg
    Prunasin

    Catalog No: CFN97566
    CAS No: 99-18-3
    Price: $223/5mg
    Apigenin 4'-O-(2'',6''-di-O-E-p-co...

    Catalog No: CFN95276
    CAS No: 71781-79-8
    Price: $318/10mg
    Stevia impurity (13-[(2-O-6-deoxy-...

    Catalog No: CFN95229
    CAS No: 1309929-72-3
    Price: $463/5mg
    Avicularin

    Catalog No: CFN98961
    CAS No: 572-30-5
    Price: $168/20mg
    Tangshenoside I

    Catalog No: CFN95108
    CAS No: 117278-74-7
    Price: $218/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2415 mL 16.2075 mL 32.4149 mL 64.8298 mL 81.0373 mL
    5 mM 0.6483 mL 3.2415 mL 6.483 mL 12.966 mL 16.2075 mL
    10 mM 0.3241 mL 1.6207 mL 3.2415 mL 6.483 mL 8.1037 mL
    50 mM 0.0648 mL 0.3241 mL 0.6483 mL 1.2966 mL 1.6207 mL
    100 mM 0.0324 mL 0.1621 mL 0.3241 mL 0.6483 mL 0.8104 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Syringaresinol-di-O-glucoside

    Catalog No: CFN90458
    CAS No: 66791-77-3
    Price: $188/20mg
    Przewalskin

    Catalog No: CFN99306
    CAS No: 119400-87-2
    Price: $398/5mg
    Ginsenoside Compound K

    Catalog No: CFN99756
    CAS No: 39262-14-1
    Price: $100/20mg
    20R-Ginsenoside Rg2

    Catalog No: CFN90412
    CAS No: 80952-72-3
    Price: $298/20mg
    Echinacoside

    Catalog No: CFN98105
    CAS No: 82854-37-3
    Price: $60/20mg
    Picroside III

    Catalog No: CFN99567
    CAS No: 64461-95-6
    Price: $228/20mg
    Linderalactone

    Catalog No: CFN99761
    CAS No: 728-61-0
    Price: $198/20mg