Labd-13-ene-8,15-diol | CAS:10267-31-9

Labd-13-ene-8,15-diol

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Description:

13(E)-Labd-13-ene-8alpha,15-diol shows antiviral and anticancer activity, it shows strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 microg/mL,respectively; it also exhibits antilung and antilaryngeal cancer activities against A549 and Hep2 cells.13(E)-Labd-13-ene-8α,15-diol inhibits the growth of the gram-positive bacteria (Staphylococcus aureus, Bacillus cereus and Listeria monocytogenes) and gram-negative bacteria (Vibrio parahaemolyticus, Escherichia coli and Salmonella enteritidis) with a range of minimum inhibitory concentration (MIC) values from 0.092 to 0.598 mg/mL and gram-negative bacteria are more sensitive to the compound (MIC, 0.092 mg/mL).

Targets:

Antifection

In vitro:

Phytother. Res.,2010 Feb;24(2):169-74.

Antiviral and anticancer activities of 13(E)-labd-13-ene-8alpha,15-diol isolated from Brachyglottis monroi.[Pubmed: 19504469 ]

METHODS AND RESULTS:
The antiviral activity of 13(E)-labd-13-ene-8alpha,15-diol (Labd-13-ene-8,15-diol,1), isolated from Brachyglottis monroi, was examined against human rhinovirus 2 (HRV2) and 3 (HRV3), and the anticancer activity on human cancer cells (A549 and Hep2). Compound (1) showed strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC(50)) of 2.68 and 0.87 microg/mL, respectively, and a 50% cytotoxicity concentration (CC(50)) of 59.45 microg/mL. Ribavirin only showed anti-HRV3 activity with an IC(50) of 30.48 microg/mL and a CC(50) > 100 microg/mL. The addition of compound (1) to HRV-infected HeLa cells directly reduced the formation of visible cytopathic effect (CPE) and it directly interacted with HRV particles. Furthermore, A549 and Hep2 cells incubated with 32 microg/mL of compound (1) for 48 h exhibited antilung and antilaryngeal cancer activities, with a viability of less than 50%.
CONCLUSIONS:
These results suggest that compound (1) may be used as a potential antiviral and anticancer agent.

J. Appl. Biol. Chem.,2013, 56(1):581-90.

Anticancer and Antimicrobial Activities of 13(E)-labd-13-ene-8α,15-diol from Brachyglottis monroi[Reference: WebLink]

In a previous study, we reported that 13(E)-labd-13- ene-8α, 15-diol (Labd-13-ene-8,15-diol ,13E) possesses antiviral and anticancer activities.
METHODS AND RESULTS:
In this study, the anticancer and antimicrobial activities of 13(E) were evaluated against 4 cancer cell lines and 6 bacteria. 13(E) showed inhibitory effect on a variety of cancer cell lines. The IC50 values was 8.3-21.3 μg/mL. 13(E) was the most effective growth inhibitor of murine leukaemia cell lines P388, producing approximately 8.3 μg/mL of IC50 in the cytopathic effect (CPE) method. 13(E) also inhibited the growth of the gram-positive bacteria (Staphyl℃℃cus aureus, Bacillus cereus and Listeria mon℃ytogenes) and gram-negative bacteria (Vibrio parahaemolyticus, Escherichia coli and Salmonella enteritidis) with a range of minimum inhibitory concentration (MIC) values from 0.092 to 0.598 mg/mL and gram-negative bacteria were more sensitive to the compound (MIC, 0.092 mg/mL).

Labd-13-ene-8,15-diol Description

Source:	The fruits of Ziziphus jujuba
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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CAS No.	10267-31-9	Price
Catalog No.	CFN99042	Purity	>=98%
Molecular Weight	308.5	Type of Compound	Diterpenoids
Formula	C₂₀H₃₆O₂	Physical Description	Powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	Labd-13-ene-8,15-diol
CAS No.:	10267-31-9
Catalog No.:	CFN99042
Molecular Formula:	C₂₀H₃₆O₂
Molecular Weight:	308.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Targets:	Antifection
Source:	The fruits of Ziziphus jujuba
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antibacterial Compound Library Antiviral Compound Library Diterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2415 mL	16.2075 mL	32.4149 mL	64.8298 mL	81.0373 mL
5 mM	0.6483 mL	3.2415 mL	6.483 mL	12.966 mL	16.2075 mL
10 mM	0.3241 mL	1.6207 mL	3.2415 mL	6.483 mL	8.1037 mL
50 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.2966 mL	1.6207 mL
100 mM	0.0324 mL	0.1621 mL	0.3241 mL	0.6483 mL	0.8104 mL

CFN99397	Scoparinol	130838-00-5	426.6	C₂₇H₃₈O₄
CFN98250	Agathadiol diacetate	24022-13-7	390.6	C₂₄H₃₈O₄
CFN89384	ent-Labda-8(17),13E-diene-3beta,15,18-triol	90851-50-6	322.48	C₂₀H₃₄O₃
CFN96078	ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside	1245636-01-4	484.6	C₂₆H₄₄O₈
CFN89220	Goshonoside F1	90851-24-4	484.63	C₂₆H₄₄O₈
CFN89238	Goshonoside F5	90851-28-8	646.77	C₃₂H₅₄O₁₃
CFN98497	Agatholal	3650-31-5	304.5	C₂₀H₃₂O₂
CFN97164	Imbricatolic acid	6832-60-6	322.5	C₂₀H₃₄O₃
CFN99882	Isocupressic acid	1909-91-7	320.5	C₂₀H₃₂O₃
CFN98880	Acetylisocupressic acid	52992-82-2	362.5	C₂₂H₃₄O₄