Linalyl acetate | CAS:115-95-7 | Manufacturer ChemFaces

Linalyl acetate

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Description:

Linalyl acetate, the main component of lavender oil is commonly used as a fragrance chemical in scented products. Linalyl acetate relaxes vascular smooth muscle through dephosphorylaton of myosin light chain. Linalyl acetate has genotoxicity.

In vitro:

Contact Dermatitis, 2010, 58(1):9-14.

Autoxidation of linalyl acetate, the main component of lavender oil, creates potent contact allergens.[Pubmed: 18154552]

Fragrances are among the most common causes of allergic contact dermatitis. We have in previous studies shown that linalool, present in lavender oil, autoxidizes on air exposure, forming allergenic oxidation products. Oxidized linalool was found to be a frequent cause of contact allergy in a patch test study on consecutive dermatitis patients. Linalyl acetate, the main component of lavender oil is commonly used as a fragrance chemical in scented products. Because of structural similarities, Linalyl acetate should also be susceptible to oxidation on air exposure, forming similar oxidation products as linalool.The aim of the present study was to investigate the autoxidation of Linalyl acetate and the influence of oxidation on its sensitizing potency.
METHODS AND RESULTS:
Analyses were performed using gas chromatography, nuclear magnetic resonance spectrometry and mass spectrometry. Sensitizing potencies of compounds were determined using the local lymph node assay (LLNA) in mice. Analyses showed that the content of Linalyl acetate decreased over time on air exposure and other compounds were formed. Hydroperoxides, an epoxide and an alcohol were identified as oxidation products from Linalyl acetate. In the LLNA, Linalyl acetate of high purity showed a weak sensitizing potency (EC3 25%). Autoxidation increased the sensitizing potency of Linalyl acetate, and a 10 weeks oxidized sample gave an EC3 value of 3.6%. As for linalool, the hydroperoxides were shown to be the oxidation products with the highest sensitizing potency.
CONCLUSIONS:
It is concluded that autoxidation of the weakly allergenic Linalyl acetate leads to formation of allergenic oxidation products.

International Congress of Pharmacology. 2006.

Linalyl acetate as a major ingredient of lavender essential oil (LEO) relaxes vascular smooth muscle through dephosphorylaton of myosin light chain.[Reference: WebLink]

Aromatherapy is widely known as an alternative treatment with essential oils. Amongthem,LEO has been reported to be effective for hypertension and atherosclerosis. Thus,the present experiments were designed to investigate whether Linalyl acetate (LA) as a major ingredient of LEO relaxes vascular smooth muscle, if so to analyze the mechanisms.
METHODS AND RESULTS:
Transverse strips of rabbit carotid arteries were used for isometric tension measurements and Western blotting to assess the phosphorylation ratio of myosin light chain (MLC). LA exerted a sustained and progressive relaxation during the contraction caused by phenylep hrine. Pharmacological analyses revealed that relaxation with LA was resulted from partially activating endothel ial NO - cyclic GMP pathway and partially reducing the MLC phosphorylation ratio in smooth muscle layer. The red uced MLC phosphrylation ratio and relaxation with LA were reversed by calyculin A as an inhibitor of MLC phosphatase. but remained unaffected by ML9 as an inhibitor of MLC kinase,suggesting the possible involve ment of activation of MLC phosphatase in causing relaxation with LA.
CONCLUSIONS:
Taken together,our results seem to be providing a new possibility on approach for vascular diseases.

Linalyl acetate Description

Source:	The essential oil of Lavender
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Cell Research:

Fitoterapia, 2013, 89(1):48-57.

Implication of limonene and linalyl acetate in cytotoxicity induced by bergamot essential oil in human neuroblastoma cells.[Pubmed: 23707744]

Bergamot (Citrus bergamia, Risso et Poiteau) essential oil (BEO) is a widely used plant extract showing anxiolytic, analgesic and neuroprotective effects in rodents; also, BEO activates multiple death pathways in cancer cells. Despite detailed knowledge of its chemical composition, the constituent/s responsible for these pharmacological activities remain largely unknown. Aim of the present study was to identify the components of BEO implicated in cell death.
METHODS AND RESULTS:
To this end, limonene, Linalyl acetate, linalool, γ-terpinene, β-pinene and bergapten were individually tested in human SH-SY5Y neuroblastoma cultures at concentrations comparable with those found in cytotoxic dilutions of BEO. None of the tested compounds elicited cell death. However, significant cytotoxicity was observed when cells were cotreated with limonene and Linalyl acetate whereas no other associations were effective. Only cotreatment, but not the single exposure to limonene and Linalyl acetate, replicated distinctive morphological and biochemical changes induced by BEO, including caspase-3 activation, PARP cleavage, DNA fragmentation, cell shrinkage, cytoskeletal alterations, together with necrotic and apoptotic cell death.
CONCLUSIONS:
Collectively, our findings suggest a major role for a combined action of these monoterpenes in cancer cell death induced by BEO.

CAS No.	115-95-7	Price	$30 / 20mg
Catalog No.	CFN70038	Purity	>=98%
Molecular Weight	196.2	Type of Compound	Monoterpenoids
Formula	C₁₂H₂₀O₂	Physical Description	Oil
Download	COA MSDS	Similar structural	Comparison

Product Name	Linalyl acetate
CAS No.:	115-95-7
Catalog No.:	CFN70038
Molecular Formula:	C₁₂H₂₀O₂
Molecular Weight:	196.2 g/mol
Purity:	>=98%
Type of Compound:	Monoterpenoids
Physical Desc.:	Oil
Source:	The essential oil of Lavender
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$30 / 20mg
Download:	COA MSDS
Similar structural:	Comparison

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Monoterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.0968 mL	25.4842 mL	50.9684 mL	101.9368 mL	127.421 mL
5 mM	1.0194 mL	5.0968 mL	10.1937 mL	20.3874 mL	25.4842 mL
10 mM	0.5097 mL	2.5484 mL	5.0968 mL	10.1937 mL	12.7421 mL
50 mM	0.1019 mL	0.5097 mL	1.0194 mL	2.0387 mL	2.5484 mL
100 mM	0.051 mL	0.2548 mL	0.5097 mL	1.0194 mL	1.2742 mL

CFN96363	Ethyl p-hydroxyphenyllactate	62517-34-4	210.2	C₁₁H₁₄O₄
CFN98075	15,16-Epoxy-12S-hydroxylabda-8(17),13(16),14-triene	216011-55-1	302.5	C₂₀H₃₀O₂
CFN90127	Dihydrochelerythrine	6880-91-7	349.38	C₂₁H₁₉NO₄
CFN70418	Hydrocotarnine hydrobromide	5985-00-2	302.2	C₁₂H₁₆BrNO₃