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Loroquine
Loroquine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Loroquine
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CAS No.: 27792-82-1
Catalog No.: CFN00296
Molecular Formula: C8H9NO2
Molecular Weight: 151.16 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
Loroquine Description
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.6155 mL 33.0775 mL 66.1551 mL 132.3101 mL 165.3877 mL
5 mM 1.3231 mL 6.6155 mL 13.231 mL 26.462 mL 33.0775 mL
10 mM 0.6616 mL 3.3078 mL 6.6155 mL 13.231 mL 16.5388 mL
50 mM 0.1323 mL 0.6616 mL 1.3231 mL 2.6462 mL 3.3078 mL
100 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3231 mL 1.6539 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
 European Journal of Organic Chemistry 1993(7):711-713.
Synthesis of 2,3Dihydro7-hydroxymethyl-1H-pyrrolizin-1-one, the Alkaloid Loroquine.[Reference: WebLink]

METHODS AND RESULTS:
The title compound 4 is synthesized in 8 steps by cyclization of N-tosylglycinate 5 with vinyl ketone 6. After elimination of water and sulfinic acid the pyrrolecarboxylate 9 is obtained which, on N-alkylation with ethyl acrylate, Dieckmann cyclization, saponification and decarboxylation, yields methylLoroquine 12. The reaction with chlorotrimethylsilane/sulfuric acid in acetic anhydride and subsequent saponification give Loroquine (4) in 2.1% overall yield.
CFN00253Danaidone6064-85-3135.16C8H9NO
CFN00279Trachelanthamidine526-64-7141.21C8H15NO
CFN00280Laburnine3348-73-0141.21C8H15NO
CFN00281Isoretronecanol526-63-6141.21C8H15NO
CFN00296Loroquine27792-82-1151.16C8H9NO2
CFN952933-Oxo-4-benzyl-3,4-dihydro-1H-pyrrolo [2,1-c] oxazine-6-methylal60026-28-0255.3C15H13NO3
CFN00328Pyrrolam A126424-76-8123.15C7H9NO
CFN00248Clazamycin B71774-49-7172.61C7H9ClN2O
CFN00250Crotanecine5096-50-4171.20C8H13NO3
CFN00252Danaidal27628-46-2135.16C8H9NO
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