Science | Nature | Cell | View More
Natural Products
Macrophylline
Macrophylline
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Macrophylline
Price:
CAS No.: 27841-97-0
Catalog No.: CFN00275
Molecular Formula: C13H21NO3
Molecular Weight: 239.31 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Senecio nemorensis L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Fraunhofer-Institut für Moleku... (Germany)
  • Biotech R&D Institute (USA)
  • Michigan State University (USA)
  • Tokyo Woman's Christian University (Japan)
  • University of Brasilia (Brazil)
  • University of Pretoria (South Africa)
  • Celltrion Chemical Research Ins... (Korea)
  • John Innes Centre (United Kingdom)
  • University of Minnesota (USA)
  • Almansora University (Egypt)
  • University of Hawaii Cancer Center (USA)
  • More...
Package
Featured Products
Trametenolic acid

Catalog No: CFN92366
CAS No: 24160-36-9
Price: $318/10mg
Malic acid

Catalog No: CFN90558
CAS No: 6915-15-7
Price: $30/20mg
Silymarin

Catalog No: CFN99542
CAS No: 22888-70-6
Price: $30/20mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Retronecine

Catalog No: CFN00322
CAS No: 480-85-3
Price: $ /
6-Prenylnaringenin

Catalog No: CFN92017
CAS No: 68236-13-5
Price: $268/10 mg
Parkeol

Catalog No: CFN92825
CAS No: 514-45-4
Price: $ / mg
Cyclo(Pro-Leu)

Catalog No: CFN90281
CAS No: 5654-86-4
Price: $238/10mg
1-O-Acetylbritannilactone

Catalog No: CFN89438
CAS No: 33627-41-7
Price: $218/20mg
Neobavaisoflavone

Catalog No: CFN92222
CAS No: 41060-15-5
Price: $60/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Macrophylline A shows weak inhibitory action on KCl-induced contraction.
In vitro:
Plant Cell Reports August 1999, Volume 18, Issue 11, pp 911-918
Induction of alkaloid diversity in hybrid plant cell cultures[Reference: WebLink]

METHODS AND RESULTS:
The treatment of Rauwolfia serpentina x Rhazya stricta somatic hybrid cell suspension culture with 100 μM of methyl jasmonate led to a general increase in indole alkaloid content and to qualitative changes in the alkaloid pattern. The content of Six alkaloids were investigated with respect to their content in both the cell biomass and nutrition medium. Intracellular 17-O-acetyl-norajmaline content on the 5th day after treatment had increased about 40-fold compared with the control culture. The respective concentrations of the other alkaloids increased by a factor of two to five.
CONCLUSIONS:
In total 26 indole alkaloids were identified in extracts of the methyl jasmonate-treated culture by TLC, UV, MS and NMR data and comparison with reference alkaloids. The identification of Macrophylline, yohimbine oxindole and yohimbine pseudoindoxyl has not been reported before in Rauwolfia serpentina or Rhazya stricta plants nor in cell cultures derived from these plants.
J Nat Prod. 2011 Jan 28;74(1):12-5.
Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.[Pubmed: 21070010]

METHODS AND RESULTS:
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, Macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 μM, respectively.
CONCLUSIONS:
Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.
Macrophylline Description
Source: The herbs of Senecio nemorensis L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
cis-Mulberroside A

Catalog No: CFN95006
CAS No: 166734-06-1
Price: $418/10mg
Japondipsaponin E1

Catalog No: CFN95354
CAS No: 175586-66-0
Price: $318/5mg
Menisperine

Catalog No: CFN95318
CAS No: 25342-82-9
Price: $318/10mg
3''-O-Caffeoylhesperidin

Catalog No: CFN95564
CAS No: N/A
Price: $318/5mg
Tetillapyrone

Catalog No: CFN95404
CAS No: 363136-43-0
Price: $413/5mg
Catechin 7-O-beta-D-glucopyranosid...

Catalog No: CFN95524
CAS No: 65597-47-9
Price: $318/10mg
4-Hydroxybenzoyl choline

Catalog No: CFN95158
CAS No: 5094-31-5
Price: $318/20mg
Toddalolactone 3'-O-methyl ether (...

Catalog No: CFN95372
CAS No: 143614-35-1
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1787 mL 20.8934 mL 41.7868 mL 83.5736 mL 104.467 mL
5 mM 0.8357 mL 4.1787 mL 8.3574 mL 16.7147 mL 20.8934 mL
10 mM 0.4179 mL 2.0893 mL 4.1787 mL 8.3574 mL 10.4467 mL
50 mM 0.0836 mL 0.4179 mL 0.8357 mL 1.6715 mL 2.0893 mL
100 mM 0.0418 mL 0.2089 mL 0.4179 mL 0.8357 mL 1.0447 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Trametenolic acid

Catalog No: CFN92366
CAS No: 24160-36-9
Price: $318/10mg
Malic acid

Catalog No: CFN90558
CAS No: 6915-15-7
Price: $30/20mg
Silymarin

Catalog No: CFN99542
CAS No: 22888-70-6
Price: $30/20mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Retronecine

Catalog No: CFN00322
CAS No: 480-85-3
Price: $ /
6-Prenylnaringenin

Catalog No: CFN92017
CAS No: 68236-13-5
Price: $268/10 mg
Parkeol

Catalog No: CFN92825
CAS No: 514-45-4
Price: $ / mg
Cyclo(Pro-Leu)

Catalog No: CFN90281
CAS No: 5654-86-4
Price: $238/10mg
1-O-Acetylbritannilactone

Catalog No: CFN89438
CAS No: 33627-41-7
Price: $218/20mg
Neobavaisoflavone

Catalog No: CFN92222
CAS No: 41060-15-5
Price: $60/20mg
Tags: buy Macrophylline | Macrophylline supplier | purchase Macrophylline | Macrophylline cost | Macrophylline manufacturer | order Macrophylline | Macrophylline distributor