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    Natural Products
    Macrophylline
    Macrophylline
    Information
    CAS No. 27841-97-0 Price
    Catalog No.CFN00275Purity>=98%
    Molecular Weight239.31Type of CompoundAlkaloids
    FormulaC13H21NO3Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Macrophylline

    Macrophylline
    Product Name Macrophylline
    CAS No.: 27841-97-0
    Catalog No.: CFN00275
    Molecular Formula: C13H21NO3
    Molecular Weight: 239.31 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source: The herbs of Senecio nemorensis L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Reprod Toxicol.2020, 96:1-10.
  • International J of Green Pharmacy2019, 13(3)
  • European Journal of Integrative Medicine2018, 20:165-172
  • Int J Mol Sci.2017, 18(5)
  • Neurochem Int.2020, 133:104629
  • J Pharm Biomed Anal2016, 118:183-194
  • J Clin Med.2019, 8(10):E1664
  • Adaptive Medicine 2020, 12(1): 4-10
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Inhibitors Compound Library
  • Alkaloids Compound Library
  • Biological Activity
    Description: Macrophylline A shows weak inhibitory action on KCl-induced contraction.
    In vitro:
    Plant Cell Reports August 1999, Volume 18, Issue 11, pp 911-918
    Induction of alkaloid diversity in hybrid plant cell cultures[Reference: WebLink]

    METHODS AND RESULTS:
    The treatment of Rauwolfia serpentina x Rhazya stricta somatic hybrid cell suspension culture with 100 μM of methyl jasmonate led to a general increase in indole alkaloid content and to qualitative changes in the alkaloid pattern. The content of Six alkaloids were investigated with respect to their content in both the cell biomass and nutrition medium. Intracellular 17-O-acetyl-norajmaline content on the 5th day after treatment had increased about 40-fold compared with the control culture. The respective concentrations of the other alkaloids increased by a factor of two to five.
    CONCLUSIONS:
    In total 26 indole alkaloids were identified in extracts of the methyl jasmonate-treated culture by TLC, UV, MS and NMR data and comparison with reference alkaloids. The identification of Macrophylline, yohimbine oxindole and yohimbine pseudoindoxyl has not been reported before in Rauwolfia serpentina or Rhazya stricta plants nor in cell cultures derived from these plants.
    J Nat Prod. 2011 Jan 28;74(1):12-5.
    Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.[Pubmed: 21070010]

    METHODS AND RESULTS:
    An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, Macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 μM, respectively.
    CONCLUSIONS:
    Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.
    Macrophylline Description
    Source: The herbs of Senecio nemorensis L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1787 mL 20.8934 mL 41.7868 mL 83.5736 mL 104.467 mL
    5 mM 0.8357 mL 4.1787 mL 8.3574 mL 16.7147 mL 20.8934 mL
    10 mM 0.4179 mL 2.0893 mL 4.1787 mL 8.3574 mL 10.4467 mL
    50 mM 0.0836 mL 0.4179 mL 0.8357 mL 1.6715 mL 2.0893 mL
    100 mM 0.0418 mL 0.2089 mL 0.4179 mL 0.8357 mL 1.0447 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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