ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $331.2 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Asian Journal of Chemistry...2014...New Zealand J. Forestry Sci.2014, 44:17Tumour Biol.2015, 36(12):9385-93Korean Journal of Pharmacognosy....2015...Mediators Inflamm.2016, 2016:7216912ARPN Journal of Eng.& Applied Sci...2016...PLoS One.2017, 12(3):e0173585Mol Pharm.2017, 14(9):3164-3177
J Sci Food Agric.2017, 97(5):1656-1662Int J Mol Sci.2018, 19(9):E2528Int J Mol Sci.2018, 19(9):E2825Nat Prod Sci.2018, 24(2):109-114Korean J. Crop Sci.2018, 63(2):131-139Postharvest Biol Tec2019, 149:18-26Food and Fermentation Industries...2019...Phytomedicine.2019, 57:95-104
Plant Cell, Tissue and Organ Cult...2020...Evid Based Complement Alternat Me...2020...Int J Mol Sci.2020, 21(19),7070.Molecules.2020, 25(17):3783.Molecules.2020, 25(21):5091.Environ Toxicol.2020, doi: 10.1002J Korean Soc Food Sci Nutr...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Universiti Malaysia Pahang (Malaysia)Sanford Burnham Medical Researc... (USA)University of Stirling (United Kingdom)S.N.D.T. Women's University (India)
Universitas islam negeri Jakarta (Indonesia)Guangzhou Institutes of Biomedi... (China)Universiti Kebangsaan Malaysia (Malaysia)MTT Agrifood Research Finland (Finland)
Max Rubner-Institut (MRI) (Germany)Harvard University (USA)Florida A&M University (USA)
Related Screening Libraries
||Vicenin-1 possesses potent anti-inflammatory and anti-oxidant activity.|
|Journal of the Korean Society for Applied Biological Chemistry, 2015, 58(3):365-371. |
|Plant-derived molecules from Saussurea grandifolia as inhibitors of aldose reductase.[Reference: WebLink]|
|Saussurea grandifolia was tested for aldose reductase (AR) inhibition as part of a search for potentially therapeutic natural compounds. |
METHODS AND RESULTS:
Stepwise polarity fractions were tested for in vitro inhibition of rat lens AR. Of these, the ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions exhibited AR inhibitory activities. A chromatographic separation of the active EtOAc and n-BuOH fractions led to the isolation of nine compounds, which were known and identified as vitexin (1), genkwanin-5-O-glucoside (2), vitexin 2″-p-hydroxybenzoate (3), kaempferol-3-O-rutinoside (4), isovitexin (5), quercitrin (6), isoquercitrin (7), 1,5-di-O-caffeoylquinic acid (8), and Vicenin -1 (9). Among these compounds, compounds 6, 7, and 8 showed very strong inhibitory activities against AR (IC50’s = 0.34, 0.32, and 0.08 μM, respectively).
The results suggest that S. grandifolia is clearly a potential source for therapeutic agent that might be useful for the treatment of diabetic complications.
Vicenin -1 Description
||The herbs of Vitex negundo L.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Regulatory Toxicology and Pharmacology, 2016:S0273230016303026. |
|Acute and repeated doses (28 days) oral toxicity study of Vicenin-1, a flavonoid glycoside isolated from fenugreek seeds in laboratory mice.[Reference: WebLink]|
|Vicenin -1 (fenugreek glycoside) has been proven to possess potent anti-inflammatory and anti-oxidant activity. The objective of the present investigation was to determine in-vivo acute and subacute (28-days repeated dose) oral toxicity of Vicenin -1 isolated from fenugreek seed.
METHODS AND RESULTS:
Vicenin-1 (93%) was isolated from a hydroalcoholic extract of fenugreek seed and characterized using HPLC, TLC, 1H NMR and 13C NMR. Acute oral toxicity (AOT) and subacute toxicity studies of Vicenin -1 were carried out according to OECD 425 (up-and-down procedure) and OCED 407 guidelines in Swiss albino mice. In AOT, Vicenin -1showed 10% mortality when administered at a dose of 5000 mg/kg. However, when vicenin-1 was administered for at doses of 37.5, 75, or 150 mg/kg 28-days it did not show any mortality at the administered doses. Vicenin -1 (75 mg/kg) did not show observational, behavioral, biochemical or histopathological toxic effects. There were minor alterations in body weight, hematology, and histopathology of mice administered with Vicenin -1
(150 mg/kg), but these changes were within normal laboratory ranges. The highest concentration of Venicin-1 was found in liver (3.46%) followed by lung (0.65%).
In conclusion, Vicenin -1 showed median lethal dose (LD50) of 4837.5 mg/kg with no-observed-adverse-effect levels (NOAEL) at 75 mg/kg and lowest adverse effect levels (LOAEL) at 150 mg/kg for both sexes of mice during AOT and sub-acute toxicity study, respectively.