Vicenin -1 | CAS:35927-38-9 Manufacturer ChemFaces

Vicenin -1

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Description:

Vicenin-1 possesses potent anti-inflammatory and anti-oxidant activity.

Targets:

Aldose reductase

In vitro:

Journal of the Korean Society for Applied Biological Chemistry, 2015, 58(3):365-371.

Plant-derived molecules from Saussurea grandifolia as inhibitors of aldose reductase.[Reference: WebLink]

Saussurea grandifolia was tested for aldose reductase (AR) inhibition as part of a search for potentially therapeutic natural compounds.
METHODS AND RESULTS:
Stepwise polarity fractions were tested for in vitro inhibition of rat lens AR. Of these, the ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions exhibited AR inhibitory activities. A chromatographic separation of the active EtOAc and n-BuOH fractions led to the isolation of nine compounds, which were known and identified as vitexin (1), genkwanin-5-O-glucoside (2), vitexin 2″-p-hydroxybenzoate (3), kaempferol-3-O-rutinoside (4), isovitexin (5), quercitrin (6), isoquercitrin (7), 1,5-di-O-caffeoylquinic acid (8), and Vicenin -1 (9). Among these compounds, compounds 6, 7, and 8 showed very strong inhibitory activities against AR (IC50’s = 0.34, 0.32, and 0.08 μM, respectively).
CONCLUSIONS:
The results suggest that S. grandifolia is clearly a potential source for therapeutic agent that might be useful for the treatment of diabetic complications.

Vicenin -1 Description

Source:	The herbs of Vitex negundo L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Animal Research:

Regulatory Toxicology and Pharmacology, 2016:S0273230016303026.

Acute and repeated doses (28 days) oral toxicity study of Vicenin-1, a flavonoid glycoside isolated from fenugreek seeds in laboratory mice.[Reference: WebLink]

Vicenin -1 (fenugreek glycoside) has been proven to possess potent anti-inflammatory and anti-oxidant activity. The objective of the present investigation was to determine in-vivo acute and subacute (28-days repeated dose) oral toxicity of Vicenin -1 isolated from fenugreek seed.
METHODS AND RESULTS:
Vicenin-1 (93%) was isolated from a hydroalcoholic extract of fenugreek seed and characterized using HPLC, TLC, 1H NMR and 13C NMR. Acute oral toxicity (AOT) and subacute toxicity studies of Vicenin -1 were carried out according to OECD 425 (up-and-down procedure) and OCED 407 guidelines in Swiss albino mice. In AOT, Vicenin -1showed 10% mortality when administered at a dose of 5000 mg/kg. However, when vicenin-1 was administered for at doses of 37.5, 75, or 150 mg/kg 28-days it did not show any mortality at the administered doses. Vicenin -1 (75 mg/kg) did not show observational, behavioral, biochemical or histopathological toxic effects. There were minor alterations in body weight, hematology, and histopathology of mice administered with Vicenin -1 (150 mg/kg), but these changes were within normal laboratory ranges. The highest concentration of Venicin-1 was found in liver (3.46%) followed by lung (0.65%).
CONCLUSIONS:
In conclusion, Vicenin -1 showed median lethal dose (LD50) of 4837.5 mg/kg with no-observed-adverse-effect levels (NOAEL) at 75 mg/kg and lowest adverse effect levels (LOAEL) at 150 mg/kg for both sexes of mice during AOT and sub-acute toxicity study, respectively.

CAS No.	35927-38-9	Price	$288 / 5mg
Catalog No.	CFN92030	Purity	>=98%
Molecular Weight	564.5	Type of Compound	Flavonoids
Formula	C₂₆H₂₈O₁₄	Physical Description	Yellow powder
Download	Manual COA MSDS SDF	Similar structural	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Anti-platelet aggregation Compound Library Radioprotectants Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7715 mL	8.8574 mL	17.7148 mL	35.4296 mL	44.287 mL
5 mM	0.3543 mL	1.7715 mL	3.543 mL	7.0859 mL	8.8574 mL
10 mM	0.1771 mL	0.8857 mL	1.7715 mL	3.543 mL	4.4287 mL
50 mM	0.0354 mL	0.1771 mL	0.3543 mL	0.7086 mL	0.8857 mL
100 mM	0.0177 mL	0.0886 mL	0.1771 mL	0.3543 mL	0.4429 mL

CFN90131	Vaccarin	53452-16-7	726.64	C₃₂H₃₈O₁₉
CFN95296	Isosaponarin 2''-O-glucoside (Isovitexin-2''-4'-di-O-beta-D-glucoside)	63316-27-8	756.7	C₃₃H₄₀O₂₀
CFN95252	Vaccarin E	2252345-81-4	904.8	C₄₂H₄₈O₂₂
CFN90134	Saponarin	20310-89-8	594.52	C₂₇H₃₀O₁₅
CFN90621	Swertisin	6991-10-2	446.4	C₂₂H₂₂O₁₀
CFN99600	Spinosin	72063-39-9	608.55	C₂₈H₃₂O₁₅
CFN90665	6'''-Feruloylspinosin	77690-92-7	784.71	C₃₈H₄₀O₁₈
CFN98601	Vitexin	3681-93-4	432.4	C₂₁H₂₀O₁₀
CFN93575	Vitexin argininate	N/A	606.6	C₂₇H₃₄N₄O₁₂
CFN70343	Vitexin 7-glucoside	35109-95-6	594.5	C₂₇H₃₀O₁₅