ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Marginatoxin
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $175.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Plant Cell,Tissue & Organ Culture...2016...Evid Based Complement Alternat Me...2016...Polytechnic University of Catalon...2017...Acta horticulturae2017, 1158:257-268J Ethnopharmacol.2017, 198:205-213Food Chem.2017, 221:1135-1144Drug Test Anal.2018, 10(10):1579-1589Nutrients.2018, 10(12)
Molecules.2018, 23(2)Front Pharmacol.2019, 10:1226Front Microbiol.2019, 10:2806BMC Complement Altern Med....2019...Exp Biol Med (Maywood)....2019...Cell Chem Biol.2019, 26(1):27-34Phytomedicine.2019, 61:152813Molecules2020, 25(4):892
J of App. Res. on Med&Aromatic Pl...2020...Drug Chem Toxicol.2020, 1-12.Drug Chem Toxicol.2020, 1-14. Nutrients.2020, 12(12):3638.Pharmaceuticals (Basel)....2020...Exp Mol Med.2020, 52(4):629-642.J Agric Food Chem....2020...
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Our products had been exported to the following research institutions and universities, And still growing.
Leibniz Institute of Plant Bioc... (Germany)Charles University in Prague (Czech Republic)VIT University (India)University of Virginia (USA)
Charles Sturt University (Denmark)Kyung Hee University (Korea)University of Ioannina (Greece)The Ohio State University (USA)
Nicolaus Copernicus Uniwersity (Poland)Instituto de Investigaciones Ag... (Chile)Universite de Lille1 (France)
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Marginatoxin
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manager@chemfaces.com
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Spectrochim Acta A2019, 210:372-380Horticulture Research2020, 7:111. Appl. Sci.2020, 10(20), 7323.Saudi Pharm J.2019, 27(1):145-153Arch Biochem Biophys.2018, 644:93-99Chem Biol Interact.2016, 260:168-175Chinese Medicine2019, 14(1)Biomolecules.2020, 10(6):925.Biochem Pharmacol. 2020, 177:114014.J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
Related Screening Libraries
| Description: |
Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway. |
| Targets: |
Caspase | Fas/FasL |
| In vitro: |
| Phytochemistry Letters, 2012, 5(2):387-392. | | A novel cytotoxic aryltetraline lactone from Bupleurum marginatum (Apiaceae)[Reference: WebLink] |
METHODS AND RESULTS:
A detailed phytochemical study of the aerial parts of Bupleurum marginatum Wall. ex DC revealed a novel aryltetraline lactone lignan identified as 9-(benzo[d][1,3]dioxol-5-yl)-6,7,8-trimethoxy-3a,4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one (Marginatoxin) along with nine known compounds and characterization of five other compounds either by GLC/MS or LC/MS techniques. Chemical structures of the isolated compounds were unambiguously elucidated by both 1D, 2D NMR and mass spectrometry techniques.The in vitro cytotoxic activity of both methanol and dichloromethane extracts as well as the isolated compounds was assessed in two human cancer cell lines HepG2 and HeLa using the MTT assay.
CONCLUSIONS:
The new aryltetraline lactone lignan exhibited a potent cytotoxic activity with IC50 values of 12.14 and 16.90 μM after 24 h treatment for HepG2 and HeLa cells, respectively. |
|
Marginatoxin Description
| Source: |
The roots of Bupleurum marginatum |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.51 mL |
12.5502 mL |
25.1004 mL |
50.2008 mL |
62.751 mL |
| 5 mM |
0.502 mL |
2.51 mL |
5.0201 mL |
10.0402 mL |
12.5502 mL |
| 10 mM |
0.251 mL |
1.255 mL |
2.51 mL |
5.0201 mL |
6.2751 mL |
| 50 mM |
0.0502 mL |
0.251 mL |
0.502 mL |
1.004 mL |
1.255 mL |
| 100 mM |
0.0251 mL |
0.1255 mL |
0.251 mL |
0.502 mL |
0.6275 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Kinase Assay: |
| Biomedical Research,2017,28(3). | | Marginatoxin induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.[Reference: WebLink] |
Marginatoxin, an aryltetraline lactone lignan isolated from Bupleurum marginatum Wall. ex DC (Apiaceae), showed cytotoxic activity against human hepatocellular carcinoma. However, the cytotoxic mechanisms of Marginatoxin against cancer cells remained unclear.
METHODS AND RESULTS:
This study was designed to investigate the detailed mechanism of its cytotoxic effect on human hepatoma BEL-7402 cells by CCK-8, flow cytometry, western blot and xenograft assays. Marginatoxin caused a dose-dependent growth inhibition of BEL-7402 cells with an IC50 of 15.20 μg/ml. Marginatoxin induced BEL-7402 cells apoptosis identified by annexing V/propidium iodide staining kits with the aid of flow cytometry. Marginatoxin-induced apoptosis was characterized by increasing Fas, FasL and Fas associated protein with death domain expression, and cleavage of caspase-8, caspase-10, caspase-3. Furthermore, the results of xenograft assay suggested that Marginatoxin inhibited the BEL-7402 cells-induced tumor growth without effect on body weight of nude mice in vivo by regulating the expression levels of above apoptotic proteins. These results demonstrated that Marginatoxin could induce apoptosis of human hepatoma BEL-7402 cells in vitro and in vivo through activation of Fas/FasL-mediated apoptotic pathway.
CONCLUSIONS:
All these findings demonstrated that Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma. Moreover, there is a need to further investigate Marginatoxin in this regard. |
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