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Methyl ganoderate A
Methyl ganoderate A
Information
CAS No. 105742-78-7 Price $413 / 5mg
Catalog No.CFN95550Purity>=98%
Molecular Weight530.7Type of CompoundTriterpenoids
FormulaC31H46O7Physical DescriptionPowder
Download COA    MSDSSimilar structuralComparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $475.0 / In-stock
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    Methyl ganoderate A

    Methyl ganoderate A
    Product Name Methyl ganoderate A
    CAS No.: 105742-78-7
    Catalog No.: CFN95550
    Molecular Formula: C31H46O7
    Molecular Weight: 530.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Source: The fruit body of Ganoderma lucidum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $413 / 5mg
    Download: COA    MSDS
    Similar structural: Comparison (Web)  (SDF)
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    product package
  • Int Immunopharmacol.2019, 71:22-31
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: Methyl ganoderate A is a Farnesyl protein transferase (FPT) inhibitor with an IC50 value of 38 microM,which has potential anticancer effects.Methyl ganoderate A has inhibitory effect on fatty acid amide hydrolase (FAAH).
    Methyl ganoderate A Description
    Source: The fruit body of Ganoderma lucidum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8843 mL 9.4215 mL 18.843 mL 37.6861 mL 47.1076 mL
    5 mM 0.3769 mL 1.8843 mL 3.7686 mL 7.5372 mL 9.4215 mL
    10 mM 0.1884 mL 0.9422 mL 1.8843 mL 3.7686 mL 4.7108 mL
    50 mM 0.0377 mL 0.1884 mL 0.3769 mL 0.7537 mL 0.9422 mL
    100 mM 0.0188 mL 0.0942 mL 0.1884 mL 0.3769 mL 0.4711 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Planta Med . 1998 May;64(4):303-308.
    Natural inhibitors for protein prenyltransferase[Pubmed: 9619109]
    Farnesyl protein transferase (FPT) catalyzes the posttranslational farnesylation of the cysteine residue located in the carboxyl-terminal tetrapeptide of the Ras oncoprotein. Prenylation of this residue is essential for membrane association and cell transforming activities of Ras. Inhibitors of FPT have been demonstrated to inhibit Ras-dependent cell transformation and thus represent a potential therapeutic strategy for the treatment of human cancers (1). In the present study, the inhibitory principles for protein prenyltransferases were isolated and identified from Ganoderma lucidum and garlic. The inhibitors from Ganoderma lucidum were identified as ganoderic acid A and ganoderic acid C by comparison with the reported spectral data. Ganoderic acid A has an IC50 value of 100 microM against FPT and its methyl ester (Methyl ganoderate A) has an IC50 value of 38 microM for the same enzyme. These inhibitors appear to be competitive with farnesyl pyrophosphate (FPP), and Ki values of ganoderic acid A and Methyl ganoderate A are 54 microM and 20 microM, respectively. The inhibitors from garlic were identified as diallyl thiosulfinate (allicin), methyl allyl thiosulfinate, and allyl methyl thiosulfinate. These inhibitors are more effective against geranylgeranyl protein transferase (GGPT) than FPT and IC50 values of allicin, methyl allyl thiosulfinate, and allyl methyl thiosulfinate for GGPT were 43 microM, 57 microM, and 53 microM, respectively. Methyl allyl thiosulfinate appears to be competitive with geranylgeranyl pyrophosphate (GGPP) and its Ki was determined to be 15 microM. The molecular structures of triterpenes and thiosulfinates are expected to be useful in designing lead compounds for new potent antitumour agents.
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