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    Natural Products
    Methyl isocostate
    Information
    CAS No. 132342-55-3 Price
    Catalog No.CFN99408Purity>=98%
    Molecular Weight248.4 Type of CompoundSesquiterpenoids
    FormulaC16H24O2Physical DescriptionOil
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Methyl isocostate

    Methyl isocostate
    Product Name Methyl isocostate
    CAS No.: 132342-55-3
    Catalog No.: CFN99408
    Molecular Formula: C16H24O2
    Molecular Weight: 248.4 g/mol
    Purity: >=98%
    Type of Compound: Sesquiterpenoids
    Physical Desc.: Oil
    Source: The roots of Aucklandia lappa Decne
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Methyl isocostate Description
    Source: The roots of Aucklandia lappa Decne
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0258 mL 20.1288 mL 40.2576 mL 80.5153 mL 100.6441 mL
    5 mM 0.8052 mL 4.0258 mL 8.0515 mL 16.1031 mL 20.1288 mL
    10 mM 0.4026 mL 2.0129 mL 4.0258 mL 8.0515 mL 10.0644 mL
    50 mM 0.0805 mL 0.4026 mL 0.8052 mL 1.6103 mL 2.0129 mL
    100 mM 0.0403 mL 0.2013 mL 0.4026 mL 0.8052 mL 1.0064 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    The Natural Products Journal, 2019, 9(4):262-267.
    Synthesis of Spiro-Isoxazolidine Derivatives of Methyl α-Isocostate.[Reference: WebLink]
    In recent decades, natural products are an important source of chemotherapeutics as more than half of the effective cancer drugs can be traced to natural origins. Moreover, the modification of natural products is one of the most common and fruitful approaches to obtain novel therapeutic agents in medicinal chemistry.
    METHODS AND RESULTS:
    Continuing with a research project based on the support of Moroccan plant resources. we report herein the use of α-isocostic acid extracted in enantiomerically pure form from Dittrichia viscosa as a convenient starting material for the synthesis of new eudesmane derivatives. Novel spiro derivatives with a natural scaffold were prepared. Spiro-isoxazolidine derivatives were generated on the exocyclic double bond adjacent to the ester α,β-unsaturated function by 1,3-dipolar cycloaddition of methyl α-isocostate(Methyl isocostate) 1 derived from sesquiterpenic isocostic acid, with nitrones 2.
    CONCLUSIONS:
    This procedure allowed us to generate enantiomerically pure spiro compounds in one diastereoisomer form with a limited number of steps. These compounds were fully characterized by spectroscopic methods.
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