ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: email@example.com
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Phytother Res.2016, 30(12):2020-2026J Chromatogr A.2017, 1518:46-58Tropical J. of Pha. Research...2017...Plant J.2017, 90(3):535-546Mol Pharm.2018, 15(8):3285-3296Int J Mol Sci.2018, 19(9):E2681Phys Chem Chem Phys....2018...Phytomedicine.2018, 40:37-47
J Sci Food Agric.2018, 98(3):1153-1161J Nat Sc Biol Med2019, 10(2):149-156Journal of Ginseng Research...2019...Front Microbiol.2019, 10:2806J of the Korean Society of Cosmet...2019...Sci Rep.2019, 9:12132Sci Rep.2019, 9:19059Biomolecules.2020, 10(2):E184
LWT-Food Sci Technol2020, 109163Int J Pharmacol2020, 16:1-9Adaptive Medicine 2020, 12(1): 4-10Int J Mol Sci.2020, 21(19),7070.J of l. Chroma.&Related Tech...2020...Clin Exp Pharmacol Physiol....2020...Ulm University Medical Center...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Chang Gung University (Taiwan)Istanbul University (Turkey)University of Otago (New Zealand)Cancer Research Initatives Foun... (Malaysia)
Sanford Burnham Medical Researc... (USA)University of Virginia (USA)Kyushu University (Japan)Chulalongkorn University (Thailand)
Universidade Federal de Goias (... (Brazil)Uniwersytet Gdański (Poland)National Cancer Center Research... (Japan)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Ind Crops Prod.2015, 67:185-191ACS Omega2020, 5,33,20825-20830Asian Pac J Cancer Prev. 2020, 21(4):935-941. Int J Mol Sci.2020, 21(24):9369.Evid Based Complement Alternat Med.2016, 2016:4357656Free Radic Biol Med.2017, 112:191-199BMC Plant Biol.2020, 20(1):214. Kor. J. Pharmacogn.2016, 47(1):62-72Int. Conference on Med. Sci. and Bio.2017, 17973J Agric Food Chem.2018, 66(1):351-358
Related Screening Libraries
Methyl isocostate Description
||The roots of Aucklandia lappa Decne
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|The Natural Products Journal, 2019, 9(4):262-267. |
|Synthesis of Spiro-Isoxazolidine Derivatives of Methyl α-Isocostate.[Reference: WebLink]|
|In recent decades, natural products are an important source of chemotherapeutics as more than half of the effective cancer drugs can be traced to natural origins. Moreover, the modification of natural products is one of the most common and fruitful approaches to obtain novel therapeutic agents in medicinal chemistry.
METHODS AND RESULTS:
Continuing with a research project based on the support of Moroccan plant resources. we report herein the use of α-isocostic acid extracted in enantiomerically pure form from Dittrichia viscosa as a convenient starting material for the synthesis of new eudesmane derivatives.
Novel spiro derivatives with a natural scaffold were prepared. Spiro-isoxazolidine derivatives were generated on the exocyclic double bond adjacent to the ester α,β-unsaturated function by 1,3-dipolar cycloaddition of methyl α-isocostate(Methyl isocostate) 1 derived from sesquiterpenic isocostic acid, with nitrones 2.
This procedure allowed us to generate enantiomerically pure spiro compounds in one diastereoisomer form with a limited number of steps. These compounds were fully characterized by spectroscopic methods.