ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $318 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
International Food Research Journ...2018...J Biochem Mol Toxicol....2021...Clin Transl Oncol.2019, 10.1007Cell Physiol Biochem....2017...J Exp Bot.2016, 67(12):3777-88Heliyon2022, 8(2):e08866.J. of Med. Plant Research.2013, 90-151Agronomy 2021, 11(3),502.
J Nat Med.2017, 71(4):745-756Nature Ecology & Evolution...2020...Phytother Res.2018, 32(5):923-932Korean Journal of Pharmacognosy...2018...Pharmaceutics2022, 14(2),376.J Bone Miner Res.2017, 32(12):2415-2430Pharmaceutics.2022, 14(3):564.Molecules.2020, 25(3):734
J Sep Sci.2020, 201901140Molecular & Cellular Toxicology...2017...Anticancer Res.2014, 34(7):3505-9Molecules2022, 27(14),4462Drug Des Devel Ther.2020, 14:61-71Int J Mol Sci.2018, 19(2)J Agric Food Chem....2021...
Our products had been exported to the following research institutions and universities, And still growing.
Florida A&M University (USA)Universidade Federal de Santa C... (Brazil)Ain Shams University (Egypt)Lodz University of Technology (Poland)
Chiang Mai University (Thailand)University of Bonn (Germany)University of Wisconsin-Madison (USA)Auburn University (USA)
Kazusa DNA Research Institute (Japan)Universidade Católica Portuguesa (Portugal)Sri Ramachandra University (India)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Spectrochim Acta A2019, 210:372-380Molecules.2021, 26(9):2765. Molecules.2019, 24(23):E4303Pharmacogn J.2022, 14(2):350-357The Korea Journal of Herbology2019, 34(2):25-32Pharm Biol.2021, 59(1):134-145.Molecules.2021, 26(18):5665.Int J Mol Sci.2021, 22(17):9400. Separation Science Plus2022, sscp.202200048.Biochem Biophys Res Commun.2018, 495(1):1271-1277
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Triterpenoids Compound Library
|| Reference standards.|
|Phytomedicine. 2011 Dec 15;19(1):32-7. |
|Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro.[Pubmed: 22133295 ]|
|The antidiabetic activity of Momordica charantia (L.), Cucurbitaceae, a widely-used treatment for diabetes in a number of traditional medicine systems, was investigated in vitro. Antidiabetic activity has been reported for certain saponins isolated from M. charantia.|
METHODS AND RESULTS:
In this study insulin secretion was measured in MIN6 β-cells incubated with an ethanol extract, saponin-rich fraction, and five purified saponins and cucurbitane triterpenoids from M. charantia, 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (3,7,25-Trihydroxycucurbita-5,23-dien-19-al, 1), momordicine I (2), momordicine II (3), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (4), and kuguaglycoside G (5). Treatments were compared to incubation with high glucose (27 mM) and the insulin secretagogue, glipizide (50 μM). At 125 μg/ml, an LC-ToF-MS characterized saponin-rich fraction stimulated insulin secretion significantly more than the DMSO vehicle, p=0.02. At concentrations 10 and 25 μg/ml, compounds 3 and 5 also significantly stimulated insulin secretion as compared to the vehicle, p≤0.007, and p=0.002, respectively.
This is the first report of a saponin-rich fraction, and isolated compounds from M. charantia, stimulating insulin secretion in an in vitro, static incubation assay.
||The fruits of Momordica charantia
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.