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2. Pharmacological research
3. Inhibitors
3,7,25-Trihydroxycucurbita-5,23-dien-19-al
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $318 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
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Revista Brasileira de Farmacognos...2021...Phytother Res.2018, 32(12):2551-2559Acta Biochim Pol.2015, 62(2):253-8Kangwon National University...2022...Int J Mol Sci.2018, 19(9):E2681The Journal of Phytopharmacology...2020...Planta Medica International...2022...RSC Advances2017, 86
Aging (Albany NY)....2021...J. of Med. Plant Research.2013, 90-151Biorxiv.2020, doi: 10.1101.Toxicol Appl Pharmacol....2022...Molecules.2019, 24(17):E3127Medicina (Kaunas).2020, 56(12):685.Int J Mol Sci.2015, 16(1):1232-51
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Our products had been exported to the following research institutions and universities, And still growing.
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Aveiro University (Portugal)University of Wisconsin-Madison (USA)John Innes Centre (United Kingdom)
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3,7,25-Trihydroxycucurbita-5,23-dien-19-al
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manager@chemfaces.com
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Int J Mol Med.2015, 35(5):1237-45Nutrients.2020, 12(11):3448. J Breast Cancer.2015, 18(2):112-118Journal of Functional Foods2022, 98:105271.J Ethnopharmacol.2016, 194:219-227Univerzita Karlova2022, 228192.Metab Eng.2022, 75:143-152.J Sep Sci.2019, 42(21):3352-3362Biomed Pharmacother.2020, 125:109784.Plants (Basel).2021, 10(4):702.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Triterpenoids Compound Library |
| Description: |
Reference standards. |
| In vitro: |
| Phytomedicine. 2011 Dec 15;19(1):32-7. | | Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro.[Pubmed: 22133295 ] | The antidiabetic activity of Momordica charantia (L.), Cucurbitaceae, a widely-used treatment for diabetes in a number of traditional medicine systems, was investigated in vitro. Antidiabetic activity has been reported for certain saponins isolated from M. charantia.
METHODS AND RESULTS:
In this study insulin secretion was measured in MIN6 β-cells incubated with an ethanol extract, saponin-rich fraction, and five purified saponins and cucurbitane triterpenoids from M. charantia, 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (3,7,25-Trihydroxycucurbita-5,23-dien-19-al, 1), momordicine I (2), momordicine II (3), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (4), and kuguaglycoside G (5). Treatments were compared to incubation with high glucose (27 mM) and the insulin secretagogue, glipizide (50 μM). At 125 μg/ml, an LC-ToF-MS characterized saponin-rich fraction stimulated insulin secretion significantly more than the DMSO vehicle, p=0.02. At concentrations 10 and 25 μg/ml, compounds 3 and 5 also significantly stimulated insulin secretion as compared to the vehicle, p≤0.007, and p=0.002, respectively.
CONCLUSIONS:
This is the first report of a saponin-rich fraction, and isolated compounds from M. charantia, stimulating insulin secretion in an in vitro, static incubation assay. |
|
3,7,25-Trihydroxycucurbita-5,23-dien-19-al Description
| Source: |
The fruits of Momordica charantia |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.1155 mL |
10.5775 mL |
21.1551 mL |
42.3101 mL |
52.8877 mL |
| 5 mM |
0.4231 mL |
2.1155 mL |
4.231 mL |
8.462 mL |
10.5775 mL |
| 10 mM |
0.2116 mL |
1.0578 mL |
2.1155 mL |
4.231 mL |
5.2888 mL |
| 50 mM |
0.0423 mL |
0.2116 mL |
0.4231 mL |
0.8462 mL |
1.0578 mL |
| 100 mM |
0.0212 mL |
0.1058 mL |
0.2116 mL |
0.4231 mL |
0.5289 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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