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    Natural Products
    Microstegiol
    Information
    CAS No. 143246-41-7 Price
    Catalog No.CFN92180Purity>=98%
    Molecular Weight298.4Type of CompoundDiterpenoids
    FormulaC20H26O2Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Microstegiol

    Microstegiol
    Product Name Microstegiol
    CAS No.: 143246-41-7
    Catalog No.: CFN92180
    Molecular Formula: C20H26O2
    Molecular Weight: 298.4 g/mol
    Purity: >=98%
    Type of Compound: Diterpenoids
    Physical Desc.: Powder
    Targets: Antifection
    Source: The roots of Salvia prionitis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Exp Parasitol.2017, 183:160-166
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antibacterial Compound Library
  • Diterpenoids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Migrostegiol has a little activity against B. subtilis.
    Targets: Antifection
    In vitro:
    Fitoterapia. 2005 Jul;76(5):450-2.
    Components and antibacterial activity of the roots of Salvia jaminiana.[Pubmed: 15893885 ]
    The acetone extract of the roots of Salvia jaminiana, containing the sterols campestanol, stigmasterol and sitosterol, and five known diterpenoids, ferruginol, cryptanol, 6,7-dehydroroyleanon, 6-hydroxysalvinolone and Microstegiol, remarkably inhibited the growth of Bacillus subtilis, Staphylococcus aureus ATCC 25923 and Streptococcus alpha-hemolitic.
    Pharmaceutical Biology, 1999 , 37 (2) :148-151.
    Cytotoxic Activity of Diterpenoids Isolated from Salvia hypargeia[Reference: WebLink]

    METHODS AND RESULTS:
    Ten diterpenoids [6a-hydroxysalvinolone (1), 6- hydroxytaxodone (2), aethiopinone (3), Microstegiol (4), ferruginol (5), saprorthoquinone (6), 11,12-dioxoabieta-8,13-diene (7), taxodione (8), hypargenin A (9), hypargenin D (10)] and three triterpenoids [lupeol 3- acetate, -oleanol 3-acetate and ß-sitosterol] were isolated from the roots of Salvia hypargeia, a plant endemic to Turkey. The crude extract and compounds 1-2, 5-10 were tested against a panel of human cancer cell lines [human breast cancer (BC 1), human lung cancer (LU 2), human colon cancer (COL 2), human epidermoidal carcinoma in mouth (KB), vinblastineresistant KB-VI, hormone-dependent human prostate cancer (LNCaP)] as well as P388 and ASK cells in culture.
    CONCLUSIONS:
    The crude extract was active in all of the test systems, except KB. Isolates 1 and 8 were also found to mediate a generalized cytotoxic response.
    Microstegiol Description
    Source: The roots of Salvia prionitis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3512 mL 16.756 mL 33.5121 mL 67.0241 mL 83.7802 mL
    5 mM 0.6702 mL 3.3512 mL 6.7024 mL 13.4048 mL 16.756 mL
    10 mM 0.3351 mL 1.6756 mL 3.3512 mL 6.7024 mL 8.378 mL
    50 mM 0.067 mL 0.3351 mL 0.6702 mL 1.3405 mL 1.6756 mL
    100 mM 0.0335 mL 0.1676 mL 0.3351 mL 0.6702 mL 0.8378 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Planta Med. 2000 Jun;66(5):458-62.
    Antibacterial diterpenes from the roots of Salvia viridis.[Pubmed: 10909268 ]
    Three new diterpenes, salviviridinol, viridinol, viridone, five known diterpenes, sugiol, 1-oxoferruginol, ferruginol, aethiopinone and Microstegiol, abietane and rearranged abietane diterpenes were isolated from the roots of Salvia viridis.
    METHODS AND RESULTS:
    These compounds were assayed against S. aureus ATCC 6538 P, E. coli ATCC 8739, P. mirabilis ATCC 14153, K. pneumonia ATCC 4352, P. aeruginosa ATCC 27853, S. epidermidis ATCC 12228, E. faecalis ATCC 29212 and a yeast C. albicans ATCC 10231.
    CONCLUSIONS:
    1-Oxoferruginol showed activity against B. subtilis, S. aureus, S. epidermidis and a modest activity against P. mirabilis, migrostegiol had a little activity against B. subtilis. The structures of the compounds were established by 1D and 2D NMR spectroscopic techniques.
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