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    Natural Products
    N-trans-caffeoyltyramine
    N-trans-caffeoyltyramine
    Information
    CAS No. 103188-48-3 Price $318 / 5mg
    Catalog No.CFN95265Purity>=98%
    Molecular Weight299.3Type of CompoundAlkaloids
    FormulaC17H17NO4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $222.6 / In-stock
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    N-trans-caffeoyltyramine

    N-trans-caffeoyltyramine
    Product Name N-trans-caffeoyltyramine
    CAS No.: 103188-48-3
    Catalog No.: CFN95265
    Molecular Formula: C17H17NO4
    Molecular Weight: 299.3 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source: The roots of Litsea hypophaea
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $318 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Int J Mol Sci. 2014, 15(5):8443-57
  • J Cancer.2019, 10(23):5843-5851
  • European Journal of Integrative Medicine2018, 20:165-172
  • Comput Biol Chem.2019, 83:107096
  • Front Pharmacol.2017, 8:205
  • Analytical methods2019, 11(6)
  • Molecules.2018, 23(2)
  • Oxid Med Cell Longev2020, 12
  • SCOPUS.2020, 836-847.
  • Inflammation2015, 38(1):445-55
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Alkaloids Compound Library
  • Biological Activity
    Description: N-trans-caffeoyltyramine is a novel and potent modulator of inflammatory responses.
    In vitro:
    International Journal of Molecular Medicine, 2015,3:1042-1048.
    N‑trans‑ρ‑caffeoyl tyramine isolated from Tribulus terrestris exerts anti‑inflammatory effects in lipopolysaccharide‑stimulated RAW 264.7 cells.[Reference: WebLink]
    Inflammation is induced by the expression of cyclooxygenase‑2 (COX‑2), which is an important mediator of chronic inflammatory diseases, such as rheumatoid arthritis, asthma and inflammatory bowel disease. Tribulus terrestris (T. terrestris) is known to have a beneficial effect on inflammatory diseases.
    METHODS AND RESULTS:
    In this study, we investigated the effects of N‑trans‑ρ‑caffeoyltyramine (N-trans-caffeoyltyramine,CT) isolated from T. terrestris on the production of nitric oxide (NO), and the expression of pro‑inflammatory cytokines and COX‑2 in lipopolysaccharide (LPS)‑stimulated RAW 264.7 cells. We also aimed to elucidate the molecular mechanisms involved. We found that the ethanolic extract of T. terrestris (EETT) and CT inhibited the production of NO, tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑6 and IL‑10 in the LPS‑stimulated RAW 264.7 cells in a dose‑dependent manner. They were determined by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). In addition, CT markedly suppressed the expression of COX‑2 and the production of prostaglandin E2 (PGE2) in response to LPS stimulation. Furthermore, CT markedly decreased p‑c‑Jun N‑terminal kinase (p‑JNK) protein expression in LPS‑stimulated RAW 264.7 cells. COX-2 and p-JNK were measured by western blot analysis.
    CONCLUSIONS:
    Taken together, these findings indicate that CT isolated from T. terrestris is a novel and potent modulator of inflammatory responses. Thus, it may prove benefiical to further evaluate CT as a possible treatment for chronic inflammatory diseases.
    N-trans-caffeoyltyramine Description
    Source: The roots of Litsea hypophaea
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3411 mL 16.7056 mL 33.4113 mL 66.8226 mL 83.5282 mL
    5 mM 0.6682 mL 3.3411 mL 6.6823 mL 13.3645 mL 16.7056 mL
    10 mM 0.3341 mL 1.6706 mL 3.3411 mL 6.6823 mL 8.3528 mL
    50 mM 0.0668 mL 0.3341 mL 0.6682 mL 1.3365 mL 1.6706 mL
    100 mM 0.0334 mL 0.1671 mL 0.3341 mL 0.6682 mL 0.8353 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Journal of the Chinese Chemical Society, 2013, 44(3):313-319.
    The Constituents from the Stems of Annona cherimola.[Reference: WebLink]

    METHODS AND RESULTS:
    Thirty‐five compounds including twenty‐one alkaloids, lysicamine (1 ), liriodenine (2 ), atherospermidine (3 ), oxoxylopine (4 ), oxoanolobine (5 ), oxoglaucine (6 ), (‐)‐anonaine (7 ), (‐)‐asimilobine (8 ), (‐)‐xylopine (9 ), (‐)‐anolobine (10 ), (‐)‐norisocorydine (11 ), (+)‐laurotetanine (12 ), (+)‐isocorydine (13 ), (‐)‐N‐methylasimilobine (14 ), (+)‐N‐methyllaurotetanine (15 ), (‐)‐norushinsunine (16 ), (‐)‐ushinsunine (17 ), (‐)‐N‐formylanonaine (18 ), (+)‐stepharine (19 ), (+)‐orentaline (20 ), and (‐)‐kikemanine (21 ); four kauranes, ent‐kaur‐16‐en‐19‐oic acid (22 ), 16β‐hydroxy‐17‐acetoxy‐ent‐kauran‐19‐al (23 ), 17‐acetoxy‐16β‐ent‐kauran‐19‐oic acid (24 ), and 16β‐hydroxy‐17‐acetoxy‐ent‐kauran‐19‐oic acid (25 ); two amides, N‐trans‐femloyltyramine (26 ), and N-trans-caffeoyltyramine (27 ); one purine, adenosine (28 ); one lactam amide, squamolone (29 ); and six steroids, β‐sitosterol (30 ), stigmasterol (31 ), β‐sitostenone (32 ), stigmasta‐4,22‐dien‐3‐one (33 ), 6β‐hydroxy‐β‐sitosterone (34 ), and 6β‐hydroxystigmasterone (35 ) are isolated from the stems of Annona cherimola.
    CONCLUSIONS:
    These compounds were characterized and identified by physical and spectral evidence. Among them, (‐)‐norisocorydine (11) was elucidated as a new enantiomer with a levorotary configuration, which is isolated for the first time.
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