| In vitro: |
| World Journal of Microbiology & Biotechnology, 2012, 28(2):1575-1583. | | Growth-inhibiting effects of Paeonia lactiflora root steam distillate constituents and structurally related compounds on human intestinal bacteria.[Reference: WebLink] |
METHODS AND RESULTS:
The growth-inhibiting activities of Paeonia lactiflora (Paeoniaceae) root steam distillate constituents and structurally related compounds against nine harmful intestinal bacteria and eight lactic acid-producing bacteria were compared with those of two antibiotics, amoxicillin and tetracycline. Thymol, α-terpinolene, (−)-perilla alcohol and (1R)-(−)-myrtenol exhibited high to extremely high levels of growth inhibition of all the harmful bacteria, whereas thymol and α-terpinolene (except for Lactobacillus casei ATCC 393) inhibited the growth of all the beneficial bacteria (MIC, both 0.08–0.62 mg mL−1). Tetracycline and amoxicillin exhibited extremely high level of growth inhibition of all the test bacteria (MIC, <0.00002–0.001 mg mL−1). 1,8-Cineole, geraniol, (−)-borneol, (1S,2S,5S)-(-)-Myrtanol, nerol, (S)-(−)-β-citronellol and (±)-lavandulol also exhibited inhibitory activity but with differing specificity and levels of activity.
CONCLUSIONS:
Structure–activity relationship indicates that structural characteristics, such as geometric isomerism, degrees of saturation, types of functional groups and types of carbon skeleton, appear to play a role in determining the growth-inhibiting activity of monoterpenoids. Global efforts to reduce the level of antibiotics justify further studies on naturally occurring P. lactiflora root-derived materials as potential preventive agents against various diseases caused by harmful intestinal bacteria such as clostridia. |
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