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1. Reference standards
2. Pharmacological research
3. Inhibitors
Methyl nomilinate
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $365.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Preprints2017, 2017120176Agronomy 2021, 11(3),502.Malaysian J of Fundamental and Ap...2018...ACS Omega.2022, 7(44):40009-40020.Appl. Sci.2020, 10(16),5482.Molecules.2020, 25(18),4089.Phytother Res.2022, 10.1002:ptr.7602.Saf Health Work.2019, 10(2):196-204
Evid Based Complement Alternat Me...2021...Chemistry of Natural Compounds...2019...Processes2020, 8(12),1540.J Microbiol Biotechnol....2022...Molecules.2019, 24(4):E744BMC Plant Biol.2022, 22(1):128.Chem Biol Interact.2018, 290:44-51J Food Biochem.2019, 43(9):e12970
Korean Journal of Pharmacognosy...2018...J AOAC Int.2021, 104(6):1634-1651.Appl. Sci.2020, 10,1304Agriculture.2022, 12(3), 342.The Journal of Phytopharmacology...2020...Acta Physiologiae Plantarum2016, 38:7J Ethnopharmacol.2020, 260:112988.
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Our products had been exported to the following research institutions and universities, And still growing.
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Methyl nomilinate
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Front Pharmacol.2022, 13:919230. ACS Pharmacol. Transl. Sci.2022, 5,7,479-490European Journal of Integrative Medicine2018, 20:165-172BMC Complement Altern Med.2018, 18(1):303Earth Environ. Sci. 2021, 905:012080.Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.Biochem Biophys Res Commun.2019, 518(4):732-738Antioxidants (Basel).2021, 10(1):112. Korean J. Medicinal Crop Sci2021, 10:345-352.University of Stuttgart2021, 11682.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro. |
| In vitro: |
| Toxicol In Vitro . 2012 Oct;26(7):1216-1223. | | Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro[Pubmed: 22728232] | | Limonoids are triterpenoids found in citrus and possess cancer preventive properties in in vitro and in vivo assays. Although several mechanisms for the chemopreventive properties of limonoids have been postulated, the specific mechanisms involved in the anti-cancer effects have not been explored. In the present study, limonoids, including Methyl nomilinate, isoobacunoic acid, isolimonexic acid (ILNA), and limonexic acid (LNA), were purified, identified by LC-MS and NMR spectral data and evaluated for their biological effects on SW480 human colon adenocarcinoma cells. Methyl nomilinate was the most potent inhibitor of cell metabolic activity in MTT and EdU incorporation assays. These limonoids did not affect apoptotic markers such as caspase-3 and PARP, but Methyl nomilinate treatment resulted in significant induction of G0/G1 cell cycle arrest. Furthermore, Methyl nomilinate suppressed CDK4/6 and cyclin D3 and the expression of CDK inhibitors. Taken together, the results suggest inhibition of cell proliferation by Methyl nomilinate occurs due to G1 cell cycle arrest, indicating that Methyl nomilinate has potential as a chemopreventive agent. | | Eur J Pharmacol . 2011 Nov 16;670(1):44-49. | | Structure-function relationships of citrus limonoids on p38 MAP kinase activity in human aortic smooth muscle cells[Pubmed: 21924259] | | Limonoids, abundantly present in citrus fruits, have potential role in reducing risk of different type of cancer. In the present study, we hypothesized that seven structurally different limonoids would involve in inflammatory pathway via modulating p38 MAP kinase activity at various extent in vascular smooth muscle cells. Results demonstrated that the different functional groups containing limonoids had differential effects on the p38 MAP kinase activity in human aortic smooth muscle cells. Among seven limonoids, nomilin exhibited the highest (38%) inhibition of p38 MAP kinase activity, followed by limonin (19%), deacetyl nomilin (19%), and defuran nomilin (17%). While defuran limonin and Methyl nomilinate showed no significant decrease in p38 MAP kinase activity, obacunone significantly increased the p38 MAP kinase activity by 38%. Furthermore, TNF-α induced p38 MAP kinase activity in the smooth muscle cells was completely inhibited by nomilin. Thus our data provide the first evidence that nomilin is the potent natural inhibitor for p38 MAP kinase activity in human aortic smooth muscle cells. These data also suggest that a seven-membered A ring with acetoxy group, present in nomilin, seems to be essential for its inhibitory activity on p38 MAP kinase. |
|
Methyl nomilinate Description
| Source: |
The fruits of Citrus reticulata Blanco. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.8295 mL |
9.1475 mL |
18.2949 mL |
36.5898 mL |
45.7373 mL |
| 5 mM |
0.3659 mL |
1.8295 mL |
3.659 mL |
7.318 mL |
9.1475 mL |
| 10 mM |
0.1829 mL |
0.9147 mL |
1.8295 mL |
3.659 mL |
4.5737 mL |
| 50 mM |
0.0366 mL |
0.1829 mL |
0.3659 mL |
0.7318 mL |
0.9147 mL |
| 100 mM |
0.0183 mL |
0.0915 mL |
0.1829 mL |
0.3659 mL |
0.4574 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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