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    Norcepharadione B
    Norcepharadione B
    Information
    CAS No. 57576-41-7 Price
    Catalog No.CFN98975Purity>=98%
    Molecular Weight307.3 Type of CompoundAlkaloids
    FormulaC18H13NO4Physical DescriptionBrown powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Norcepharadione B

    Norcepharadione B
    Product Name Norcepharadione B
    CAS No.: 57576-41-7
    Catalog No.: CFN98975
    Molecular Formula: C18H13NO4
    Molecular Weight: 307.3 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Brown powder
    Targets: PAFR | HSV
    Source: The herbs of Houttuynia cordata Thunb
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticancer Compound Library
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  • Biological Activity
    Description: Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro. Norcepharadione B shows significant inhibitory effects on both ADP-induced and thrombin-induced platelet aggregation.
    Targets: PAFR | HSV
    In vitro:
    Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1227-30.
    The constituents and their bioactivities of Houttuynia cordata.[Pubmed: 19881272]

    METHODS AND RESULTS:
    Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, Norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated.
    CONCLUSIONS:
    Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 microM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 microM.
    Arch Pharm Res. 2001 Dec;24(6):518-21.
    Cytotoxic alkaloids from Houttuynia cordata.[Pubmed: 11794526]

    METHODS AND RESULTS:
    Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), Norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata.
    CONCLUSIONS:
    Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
    Chinese Journal of Natural Medicines, 2011, 9(6):425-8.
    Alkaloids from Houttuynia cordata and Their Antiplatelet Aggregation Activities.[Reference: WebLink]
    To study the chemical constituents from Houttuynia cordata and to test their antiplatelet aggregation activities.Methods The chemical constituents were isolated and purified by silica gel column chromatography and their structures were elucidated on the basis of spectral analysis. The antiplatelet aggregation activities were evaluated by Born's method, using rat PRP induced by ADP and thrombin.ResultsNine alkaloids were isolated and their structures were identified as Norcepharadione B (1), 4, 5-dioxodehydroasimilobine (2), cepharadione B (3), aristololactam B II (4), aristololactam A II (5), sauristolactam (6), piperolactam A (7), splendidine (8), and aristololactam F II (9). Antiplatelet aggregation test indicated significant inhibitory activities of compounds 1, 2, 4–7, 9 induced by ADP and 1, 2, 4, 7 induced by thrombin.Conclusion Compounds 2, 6, 7, 9 were isolated from the genus Houttuynia for the first time. Compounds 1, 2, 4, 7 showed significant inhibitory effects on both ADP-induced and thrombin-induced platelet aggregation.
    Norcepharadione B Description
    Source: The herbs of Houttuynia cordata Thunb
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2541 mL 16.2707 mL 32.5415 mL 65.083 mL 81.3537 mL
    5 mM 0.6508 mL 3.2541 mL 6.5083 mL 13.0166 mL 16.2707 mL
    10 mM 0.3254 mL 1.6271 mL 3.2541 mL 6.5083 mL 8.1354 mL
    50 mM 0.0651 mL 0.3254 mL 0.6508 mL 1.3017 mL 1.6271 mL
    100 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.6508 mL 0.8135 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chulalongkorn University. 1996.
    Antimalarial compounds from Goniothalamus tenuifolius.[Reference: WebLink]

    METHODS AND RESULTS:
    1996 In the search for antimalarial compounds from Goniothalamus tenuifolius, four aristolactam alkaloids, namely aristolactam BI, aristolactam BII, velutinam and aristolactam AII were isolated along with a 4, 5-dioxoaporphine alkaloid named Norcepharadione B, and an ethyl ester of 2, 4-dihydroxy-6-methylbenzoic acid. The structure identifications of all of the isolated compounds, including their unequivocal 13C NMR assignments, were achieved by analysis of their UV, IR, MS and NMR data. All compounds were evaluated for their antimalarial activity against Plasmodium falciparum T9/94 by radioisotope microdilution technique.
    CONCLUSIONS:
    The ethyl ester of 2, 4-dihydroxy-6-methylbenzoic acid, aristolactam BI, aristolactam BII, velutinam, Norcepharadione B and aristolactam AII showed EC50 values of 33, 10.5, 11, 7.5, 7.5 and 9.5 mug/ml, respectively, whereas those of chloroquine and pyrimethamine were 0.03 and 2.8 mug/ml, respectively. This investigation is the first report of antimalarial activity of aristolactam alkaloids.
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