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|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Asian J Beauty Cosmetol...2016...Onco Targets Ther.2017, 10:3467-3474Biochem Systematics and Ecology...2017...Biochem Pharmacol.2017, 130:10-20Naunyn Schmiedebergs Arch Pharmac...2017...Universidade Estadual Paulista...2017...Cell Biochem Funct.2018, 36(6):303-311Journal of Third Military Medical...2018...
Front Pharmacol.2018, 9:236Int J Mol Sci.2019, 20(11):E2734Int J Mol Sci.2019, 20(16):E4015Int J Mol Sci.2019, 20(9):E2244Molecules.2019, 24(11):E2102Molecules.2019, 24(2):E343Int J Mol Med.2019, 43(6):2516-2522J Mater Chem B.2019, 7(39):5896-5919
Sci Rep.2019, 9:12132Biomolecules.2020, 10(6):925.Pharmaceutics.2020, 12(9):845.Drug Des Devel Ther.2020, 14:5189-5204.ACS Synth Biol.2020, 9(9):2282-2290.Environ Toxicol.2020, doi: 10.1002Molecules2021, 26(1),230
Our products had been exported to the following research institutions and universities, And still growing.
Monash University (Australia)Regional Crop Research Institute (Korea)University of Toronto (Canada)Univerzita Karlova v Praze (Czech Republic)
Universitas Airlangga (Indonesia)Seoul National University (Korea)Seoul National University of Sc... (Korea)University of Dicle (Turkey)
Chulalongkorn University (Thailand)Semmelweis Unicersity (Hungary)National Cancer Institute (USA)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Industrial Crops and Products2017, 95:286-295Plant Growth Regulation2020, 90(2):383-392Chemistry of Plant Raw Materials2019, 4:135-147J Cell Physiol.2020, 10.1002Biomed Sci Letters.2020, 26:319-326African J. Agricultural Research 2017, 12(13):1164-1168Molecules.2016, 21(6)Exp Parasitol.2015, 153:160-4Front Pharmacol.2019, 10:1226Nat Prod Commun.2014, 9(5):679-82
Related Screening Libraries
||Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro. Norcepharadione B shows significant inhibitory effects on both ADP-induced and thrombin-induced platelet aggregation.|
||PAFR | HSV|
|Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1227-30. |
|The constituents and their bioactivities of Houttuynia cordata.[Pubmed: 19881272]|
METHODS AND RESULTS:
Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, Norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated.
Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 microM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 microM.
|Arch Pharm Res. 2001 Dec;24(6):518-21. |
|Cytotoxic alkaloids from Houttuynia cordata.[Pubmed: 11794526]|
METHODS AND RESULTS:
Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), Norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata.
Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
|Chinese Journal of Natural Medicines, 2011, 9(6):425-8. |
|Alkaloids from Houttuynia cordata and Their Antiplatelet Aggregation Activities.[Reference: WebLink]|
|To study the chemical constituents from Houttuynia cordata and to test their antiplatelet aggregation activities.Methods The chemical constituents were isolated and purified by silica gel column chromatography and their structures were elucidated on the basis of spectral analysis. The antiplatelet aggregation activities were evaluated by Born's method, using rat PRP induced by ADP and thrombin.ResultsNine alkaloids were isolated and their structures were identified as Norcepharadione B (1), 4, 5-dioxodehydroasimilobine (2), cepharadione B (3), aristololactam B II (4), aristololactam A II (5), sauristolactam (6), piperolactam A (7), splendidine (8), and aristololactam F II (9). Antiplatelet aggregation test indicated significant inhibitory activities of compounds 1, 2, 4–7, 9 induced by ADP and 1, 2, 4, 7 induced by thrombin.Conclusion Compounds 2, 6, 7, 9 were isolated from the genus Houttuynia for the first time. Compounds 1, 2, 4, 7 showed significant inhibitory effects on both ADP-induced and thrombin-induced platelet aggregation.|
Norcepharadione B Description
||The herbs of Houttuynia cordata Thunb
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chulalongkorn University. 1996. |
|Antimalarial compounds from Goniothalamus tenuifolius.[Reference: WebLink]|
METHODS AND RESULTS:
1996 In the search for antimalarial compounds from Goniothalamus tenuifolius, four aristolactam alkaloids, namely aristolactam BI, aristolactam BII, velutinam and aristolactam AII were isolated along with a 4, 5-dioxoaporphine alkaloid named Norcepharadione B, and an ethyl ester of 2, 4-dihydroxy-6-methylbenzoic acid. The structure identifications of all of the isolated compounds, including their unequivocal 13C NMR assignments, were achieved by analysis of their UV, IR, MS and NMR data. All compounds were evaluated for their antimalarial activity against Plasmodium falciparum T9/94 by radioisotope microdilution technique.
The ethyl ester of 2, 4-dihydroxy-6-methylbenzoic acid, aristolactam BI, aristolactam BII, velutinam, Norcepharadione B and aristolactam AII showed EC50 values of 33, 10.5, 11, 7.5, 7.5 and 9.5 mug/ml, respectively, whereas those of chloroquine and pyrimethamine were 0.03 and 2.8 mug/ml, respectively. This investigation is the first report of antimalarial activity of aristolactam alkaloids.