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    Natural Products
    Picrasidine I
    Picrasidine I
    Information
    CAS No. 100234-59-1 Price $368 / 5mg
    Catalog No.CFN99019Purity>=98%
    Molecular Weight240.3Type of CompoundAlkaloids
    FormulaC14H12N2O2Physical DescriptionYellow powder
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $257.6 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Picrasidine I

    Picrasidine I
    Product Name Picrasidine I
    CAS No.: 100234-59-1
    Catalog No.: CFN99019
    Molecular Formula: C14H12N2O2
    Molecular Weight: 240.3 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Yellow powder
    Targets: MAPK | NF-魏B | ROS | c-Fos | NFATc1
    Source: The barks of Picrasma quassioides.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $368 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Institut Pasteur Korea2020, doi: 10.21203.
  • J Mol Med (Berl).2018, 96(7):661-672
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Biological Activity
    Description: Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.
    Targets: MAPK | NF-κB | ROS | c-Fos | NFATc1
    Picrasidine I Description
    Source: The barks of Picrasma quassioides.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1615 mL 20.8073 mL 41.6146 mL 83.2293 mL 104.0366 mL
    5 mM 0.8323 mL 4.1615 mL 8.3229 mL 16.6459 mL 20.8073 mL
    10 mM 0.4161 mL 2.0807 mL 4.1615 mL 8.3229 mL 10.4037 mL
    50 mM 0.0832 mL 0.4161 mL 0.8323 mL 1.6646 mL 2.0807 mL
    100 mM 0.0416 mL 0.2081 mL 0.4161 mL 0.8323 mL 1.0404 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Cell Research:
    Cellular Physiology & Biochemistry, 2017:1425-1435.
    Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production.[Reference: WebLink]
    Osteoporosis is a metabolic bone disorder that tortures about millions of people worldwide. Recent study demonstrated agents derived from picrasma quassioides is a promising drug for targets multiple signaling pathways. However its potential in treatment of bone loss has not been fully understood.
    METHODS AND RESULTS:
    The bone marrow macrophages (BMMs) were cultured and induced with M-CSF and RANKL followed by Picrasidine I (PI) treatment. Then the effects of PI on osteoclast formation were evaluated by counting tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells. Moreover, effects of PI on bone resorption activity of mature osteoclast were studied through bone resorption pit counting and actin ring structure analysis. Further, the involved potential signaling pathways cross-talking were investigated by performed Western blotting and quantitative real-time PCR examination. Results demonstrated PI strongly inhibited RANKL induced osteoclast formation from its precursors. Mechanistically, the inhibitory effect of PI on osteoclast differentiation was due to the suppression of osteoclastogenic transcription factors, c-Fos and NFATc1. Moreover, PI markedly blocked the RANKL-induced osteoclastogenesis by attenuating MAPKs and NF-κB signaling pathways. In addition, PI decreased the ROS generation in osteoclast and osteoblast.
    CONCLUSIONS:
    Taken together our data demonstrate that PI has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.
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