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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $257.6 / In-stock||Other Packaging
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More articles cited ChemFaces products.
J. of Med. Plant Research.2013, 90-151J Ethnopharmacol.2017, 198:87-90J Nat Prod.2017, 80(4):854-863Neurochem Int.2018, 121:114-124Phytomedicine.2018, 38:12-23Front Plant Sci.2018, 9:1424Cardiovasc Toxicol.2019, 19(4):297-305J Sep Sci.2019, 42(21):3352-3362
Cell Mol Biol(Noisy-le-grand)...2019...Chem Pharm Bull (Tokyo)....2019...Planta Med.2019, 85(4):347-355Internoational J of Toxicology...2020...Nutrients.2020, 12(12):3607. Toxins (Basel).2020, 12(4):210. J Neuroinflammation.2020, 17(1):75.Int J Mol Sci.2020, 21(9):3392.
Molecules.2020, 25(23):5556. J Ethnopharmacol.2020, 269:113752. Dicle Tip Dergisi2020, 47(2),423-430.Heliyon2020, 6(6):e04337.Nature Ecology & Evolution...2020...Research Square2020, doi: 10.21203.Inflammation.2021, doi: 10.1007
Our products had been exported to the following research institutions and universities, And still growing.
National Cancer Center Research... (Japan)University of Toronto (Canada)Sanford Burnham Prebys Medical ... (USA)Agricultural Research Organizat... (Israel)
Macau University of Science and... (China)Heidelberg University (Germany)Florida International University (USA)Aveiro University (Portugal)
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Institut Pasteur Korea2020, doi: 10.21203.J Mol Med (Berl).2018, 96(7):661-672Preprints2017, 2017120176J Sep Sci.2018, 41(11):2488-2497Asian Pac J Tropical Bio.2020, 10(6):239-247J Korean Soc Food Sci Nutr2020, doi: 10.3746.Plant Foods Hum Nutr.2020, 10.1007Advances in Traditional Medicine2020, 10.1007J Med Food.2020, 23(6):633-640.Drug Chem Toxicol.2020, 1-14.
Related Screening Libraries
||Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.|
||MAPK | NF-κB | ROS | c-Fos | NFATc1|
Picrasidine I Description
||The barks of Picrasma quassioides.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Cellular Physiology & Biochemistry, 2017:1425-1435. |
|Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production.[Reference: WebLink]|
|Osteoporosis is a metabolic bone disorder that tortures about millions of people worldwide. Recent study demonstrated agents derived from picrasma quassioides is a promising drug for targets multiple signaling pathways. However its potential in treatment of bone loss has not been fully understood. |
METHODS AND RESULTS:
The bone marrow macrophages (BMMs) were cultured and induced with M-CSF and RANKL followed by Picrasidine I (PI) treatment. Then the effects of PI on osteoclast formation were evaluated by counting tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells. Moreover, effects of PI on bone resorption activity of mature osteoclast were studied through bone resorption pit counting and actin ring structure analysis. Further, the involved potential signaling pathways cross-talking were investigated by performed Western blotting and quantitative real-time PCR examination. Results demonstrated PI strongly inhibited RANKL induced osteoclast formation from its precursors. Mechanistically, the inhibitory effect of PI on osteoclast differentiation was due to the suppression of osteoclastogenic transcription factors, c-Fos and NFATc1. Moreover, PI markedly blocked the RANKL-induced osteoclastogenesis by attenuating MAPKs and NF-κB signaling pathways. In addition, PI decreased the ROS generation in osteoclast and osteoblast.
Taken together our data demonstrate that PI has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.