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    Natural Products
    Poricoic acid A(F)
    Information
    CAS No. 137551-38-3 Price $218 / 10mg
    Catalog No.CFN92838Purity>=98%
    Molecular Weight498.7Type of CompoundTriterpenoids
    FormulaC31H46O5Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $141.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Poricoic acid A(F)

    Poricoic acid A(F)
    Product Name Poricoic acid A(F)
    CAS No.: 137551-38-3
    Catalog No.: CFN92838
    Molecular Formula: C31H46O5
    Molecular Weight: 498.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: Immunology & Inflammation related | Tyrosinase
    Source: The roots of Wolfiporia cocos (Schw.) Ryv.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $218 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • BMC Complement Altern Med.2014, 14:352
  • Biomed Chromatogr.2020, e5021.
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Appl. Sci.2020, 10(23), 8729
  • Mediators Inflamm. 2016, 2016:6189590
  • Nat Prod Sci.2018, 24(2):109-114
  • J Med Food.2019, 22(10):1067-1077
  • Molecules.2020, 25(9):2111.
  • Cell Death Dis.2019, 10(12):882
  • Sci Rep. 2018, 1-9
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
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  • Biological Activity
    Description: Poricoic acid A(F) shows anti-inflammatory activity. It is a potential whitening active ingredient, it exhibits good inhibitory effects on the activities of monophenolase and diphenolase in mushroom tyrosinase, as well as a certain inhibitory effect on tyrosinase in B16 cells.
    Targets: Immunology & Inflammation related | Tyrosinase
    In vitro:
    Zhongcaoyao, 2017(9):328.
    Tyrosinase Inhibitory Activity of Total Triterpenes and Poricoic Acid A Isolated from Poria cocos.[Reference: WebLink]
    With the improvement of people's living standards, people's requests for beauty are increasing. Skin whitening and lightening have become the pursuit of many women, and whitening and removing freckles have become the focus of scientific research. At present, widely used whitening agents, such as kojic acid, vitamin C, and its derivatives, have shortcomings such as poor stability and retarded effect. Therefore, safer and more effective whitening products from herbs are urgently needed. To explore the possibility of triterpenes as whitening active substance, the effects of total triterpenes of Poria (TTP) and Poricoic acid A(F) (PAA) on mushroom tyrosinase activities and B16 cells were investigated, and their mechanisms on mushroom tyrosinase were also studied.
    METHODS AND RESULTS:
    Using arbutin and nicotinamide as reference substances, we determinated the inhibitory effects of TTP and PAA on mushroom tyrosinase and tyrosinase in B16 cells and then studied the inhibitory mechanism on mushroom tyrosinase. TTP and PAA exhibited good inhibitory effects on the activities of monophenolase and diphenolase in mushroom tyrosinase, as well as a certain inhibitory effect on tyrosinase in B16 cells.
    CONCLUSIONS:
    TTP and PAA are potential whitening active ingredients.
    Journal of Natural Products, 2011, 74(2):137-144.
    Cytotoxic and Apoptosis-Inducing Activities of Triterpene Acids from Poria cocos.[Reference: WebLink]

    METHODS AND RESULTS:
    Six lanostane-type triterpene acids (1a-6a), isolated from Poria cocos , and their methyl ester (1b-6b) and hydroxy derivatives (1c-6c) were prepared. Upon evaluation of the cytotoxic activity of these compounds against leukemia (HL60), lung (A549), melanoma (CRL1579), ovary (NIH:OVCAR-3), breast (SK-BR-3), prostate (DU145), stomach (AZ521), and pancreas (PANC-1) cancer cell lines, 11 compounds (5a, 6a, 2b-5b, 1c, and 3c-6c) exhibited activity with single-digit micromolar IC(50) values against one or more cell lines. Poricotriol A (1c), a hydroxy derivative of Poricoic acid A(F) (1a), exhibited potent cytotoxicities against six cell lines with IC(50) values of 1.2-5.5 μM. poricotriol Ainduced typical apoptotic cell death in HL60 and A549 cells on evaluation of the apoptosis-inducing activity by flow cytometric analysis. Western blot analysis in HL60 cells showed that poricotriol A activated caspases-3, -8, and -9, while increasing the ratio of Bax/Bcl-2.
    CONCLUSIONS:
    This suggested that poricotriol A induced apoptosis via both mitochondrial and death receptor pathways in HL60. On the other hand, poricotriol A did not activate caspases-3, -8, and -9, but induced translocation of apoptosis-inducing factor (AIF) from mitochondria and increased the ratio of Bax/Bcl-2 in A549. This suggested that poricotriol A induced apoptosis via the mitochondrial pathway mostly by translocation of AIF, independent from the caspase pathway in A549. Furthermore, poricotriol A was shown to possess high selective toxicity in lung cancer cells since it exhibited only weak cytotoxicity against a normal lung cell line (WI-38).
    Poricoic acid A(F) Description
    Source: The roots of Wolfiporia cocos (Schw.) Ryv.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0052 mL 10.0261 mL 20.0521 mL 40.1043 mL 50.1303 mL
    5 mM 0.401 mL 2.0052 mL 4.0104 mL 8.0209 mL 10.0261 mL
    10 mM 0.2005 mL 1.0026 mL 2.0052 mL 4.0104 mL 5.013 mL
    50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.8021 mL 1.0026 mL
    100 mM 0.0201 mL 0.1003 mL 0.2005 mL 0.401 mL 0.5013 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Phytotherapy Research, 1996, 10(7):581-584.
    Inhibitory Effect of Poria cocos on 12‐O‐Tetradecanoylphorbol‐13‐Acetate‐Induced Ear Oedema and Tumour Promotion in Mouse Skin.[Reference: WebLink]

    METHODS AND RESULTS:
    The methanol extract from the sclerotium of Poria cocos was found to inhibit 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced tumour promotion in two-stage carcinogenesis in mouse skin. From the active fraction of the extract, eight lanostane-type triterpene acids and four 3,4-secolanostane-type triterpene acids were isolated. The isolated compounds showed inhibitory activity against TPA-induced ear inflammatory oedema.
    CONCLUSIONS:
    The 50% inhibitory dose of pachymic acid, 3- O -acetyl-16α-hydroxytrametenolic acid, dehydropachymic acid, dehydroeburiconic acid, 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid, Poricoic acid A(F) and poricoic acid B for TPA-induced inflammation was 17–44 μg/ear, at a grade corresponding to that of hydrocortisone.
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