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    Natural Products
    Quercetin-3-O-glucose-6''-acetate
    Information
    CAS No. 54542-51-7 Price $318 / 10mg
    Catalog No.CFN94466Purity>=98%
    Molecular Weight506.41Type of CompoundFlavonoids
    FormulaC23H22O13Physical DescriptionYellow powder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / $229.0 / In-stock
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    Quercetin-3-O-glucose-6''-acetate

    Quercetin-3-O-glucose-6''-acetate
    Product Name Quercetin-3-O-glucose-6''-acetate
    CAS No.: 54542-51-7
    Catalog No.: CFN94466
    Molecular Formula: C23H22O13
    Molecular Weight: 506.41 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: NADPH-oxidase | ROS
    Source: The leaves of Morus alba L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $318 / 10mg
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antioxidants Compound Library
  • Inhibitors Compound Library
  • Flavonoids Compound Library
  • ROS Inhibitor Library
  • NADPH-oxidase Inhibitor Library
  • Biological Activity
    Description: Quercetin-3-O-glucose-6''-acetate is a NADPH oxidase inhibitor, it has antioxidant capacity.
    Targets: NADPH-oxidase | ROS
    In vitro:
    J Food Sci. 2011 Aug;76(6):C869-73.
    Flavonol content in the water extract of the mulberry (Morus alba L.) leaf and their antioxidant capacities.[Pubmed: 22417484]
    The biological activities of the mulberry (Morus alba L.) leaf have been attributed to its flavonoid content.
    METHODS AND RESULTS:
    The water extract of the mulberry leaf (WEML) was prepared by autoclaving at 121 °C for 15 min, and the flavonol content of the WEML was determined by HPLC The WEML contained 4 flavonols in the following order: quercetin-3-β-D-glucose (QT-G) > quercetin-3-O-glucose-6″-acetate (QT-GA) > rutin (RT) > quercetin (QT). In the oxygen radical absorbance capacity (ORAC) assay, QT had the highest peroxyl radical-scavenging capacity and a similar hydroxyl radical-scavenging capacity as its glycosides (QT-G, QT-GA, and RT).
    CONCLUSIONS:
    QT exhibited a stronger cellular antioxidant capacity (CAC) against 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH)- and Cu²⁺-induced oxidative stress in HepG2 cells compared to its glycosides, indicating that the intracellular antioxidant capacity of QT and its glycosides may depend upon both the permeability across the cell membrane and the peroxyl or hydroxyl radical-scavenging capacity.
    In vivo:
    Mol Cell Biochem. 2011 Jun;352(1-2):91-8.
    A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants.[Pubmed: 21312054]
    NADPH oxidase is the major source of non-mitochondrial cellular reactive oxygen species (ROS), and also is reported to be a major cause of various diseases including atherosclerosis and hypertension.
    METHODS AND RESULTS:
    In order to screen a new curative reagent that can suppress NADPH oxidase activity, we developed a Drosophila melanogaster fly that would overexpress human Dual oxidase 2 (hDuox2), a member of the NADPH oxidase family, as a screening model. These flies (GMR-GAL4/UAS-hDuox2) had a high generation of ROS in the posterior region of the eye discs along with an easily recognizable rough-eye phenotype, which is an ideal and convenient marker for further screening steps. Moreover, the hDuox2-induced rough-eye phenotype can be rescued by feeding with a culture medium containing mulberry leaves (MLs), which reportedly have an antimetabolic effect. Some commercially available antioxidants such as quercetin-3-O-D-glucoside or Quercetin-3-O-glucose-6''-acetate, or the naringin contained in MLs and other herbs, also have shown a similar suppressing effect on the rough-eye phenotype.
    METHODS AND RESULTS:
    Our results suggest that flavonoid glycoside is absorbed from the intestine and functions in the body of D. melanogaster as it does in mammalian models such as rats. Thus, the GMR-GAL4/UAS-hDuox2 fly line is a promising model for the screening of novel drugs such as NADPH oxidase inhibitors and/or antioxidants.
    Quercetin-3-O-glucose-6''-acetate Description
    Source: The leaves of Morus alba L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9747 mL 9.8734 mL 19.7468 mL 39.4937 mL 49.3671 mL
    5 mM 0.3949 mL 1.9747 mL 3.9494 mL 7.8987 mL 9.8734 mL
    10 mM 0.1975 mL 0.9873 mL 1.9747 mL 3.9494 mL 4.9367 mL
    50 mM 0.0395 mL 0.1975 mL 0.3949 mL 0.7899 mL 0.9873 mL
    100 mM 0.0197 mL 0.0987 mL 0.1975 mL 0.3949 mL 0.4937 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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