ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Safflospermidine A
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / $475.0 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
The Korea Journal of Herbology...2019...Nutrients.2021, 13(8):2901.J Chromatogr B Analyt Technol Bio...2020...Int J Mol Sci.2018, 19(2)Journal of Oil Palm Research...2019...Pak J Pharm Sci.2018, 31:311-315J Control Release.2021, 336:159-168. Appl. Sci.2020, 10(8),2804
Int J Mol Med.2015, 35(5):1237-45Food Chem.2022, 378:131975.PLoS One.2018, 13(4):e0195642Molecules.2018, 23(7):E1817Food Chem.2017, 221:1135-1144Pharmacognosy Journal....2020...J Agric Food Chem....2021...J of Food Quality2020, 8851285.
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Our products had been exported to the following research institutions and universities, And still growing.
Institute of Pathophysiology Me... (Austria)University of Toronto (Canada)Monash University (Australia)Helmholtz Zentrum München (Germany)
University of Limpopo (South Africa)Universite de Lille1 (France)Uniwersytet Gdański (Poland)Universiti Sains Malaysia (Malaysia)
University of Lodz (Poland)The Ohio State University (USA)Chungnam National University (Korea)
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Safflospermidine A
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Clin Exp Pharmacol Physiol.2015, 42(11):1189-97Int J Mol Med.2016, 37(2):501-8Food Chem.2018, 262:78-85Evid Based Complement Alternat Med.2020, 2020:9416962.Postharvest Biol Tec2019, 149:18-26Journal of Life Science2017, 233-240bioRxiv2021, 462065.Chin. Med.J.Res. Prac.2017, 31(4)Journal of Ginseng Research2021, 3 June.Enzyme Microb Technol.2022, 153:109941.
Related Screening Libraries
Description: |
Safflospermidine A is a potential natural tyrosinase inhibitor,it shows high antityrosinase activity (IC50 of 13.8 μM). |
Targets: |
Tyrosinase |
In vitro: |
Heliyon, 2020, 6(3):e03638. | Safflospermidines from the bee pollen of Helianthus annuus L. exhibit a higher in vitro antityrosinase activity than kojic acid.[Reference: WebLink] | Ozone deterioration in the atmosphere has become a severe problem causing overexposure of ultraviolet light, which results in humans in melanin overproduction and can lead to many diseases, such as skin cancer and melasma, as well as undesirable esthetic appearances, such as freckles and hyperpigmentation. Although many compounds inhibit melanin overproduction, some of them are cytotoxic, unstable, and can cause skin irritation. Thus, searching for new natural compounds with antityrosinase activity and less/no side effects is still required. Here, bee pollen derived from sunflower (Helianthus annuus L.) was evaluated. METHODS AND RESULTS: Sunflower bee pollen (SBP) was collected from Apis mellifera bees in Lopburi province, Thailand in 2017, extracted by methanol and sequentially partitioned with hexane and dichloromethane (DCM). The in vitro antityrosinase activity was evaluated using mushroom tyrosinase and the half maximal inhibitory concentration (IC50) is reported. The antioxidation activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and reported as the half maximal effective concentration. Two pure compounds with antityrosinase activity were isolated by silica gel 60 column chromatography (SG60CC) and high performance liquid chromatography (HPLC), and their chemical structure deduced by Nuclear Magnetic Resonance (NMR) analysis. The DCM partitioned extract of SBP (DCMSBP) had an antityrosinase activity (IC50, 159.4 μg/mL) and was fractionated by SG60CC, providing five fractions (DCMSBP1–5). The DCMSBP5 fraction was the most active (IC50 = 18.8 μg/mL) and further fractionation by HPLC gave two active fractions, revealed by NMR analysis to be Safflospermidine A and B. Interestingly, both Safflospermidine A and B had a higher antityrosinase activity (IC50 of 13.8 and 31.8 μM, respectively) than kojic acid (IC50 of 44.0 μM). However, fraction DCMSBP5 had no significant antioxidation activity, while fractions DCMSBP1–4 showed a lower antioxidation activity than ascorbic acid. CONCLUSIONS: Safflospermidine A and Safflospermidine B are potential natural tyrosinase inhibitors. |
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Safflospermidine A Description
Source: |
The herbs of Helianthus annuus L. |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
1.7132 mL |
8.566 mL |
17.1321 mL |
34.2642 mL |
42.8302 mL |
5 mM |
0.3426 mL |
1.7132 mL |
3.4264 mL |
6.8528 mL |
8.566 mL |
10 mM |
0.1713 mL |
0.8566 mL |
1.7132 mL |
3.4264 mL |
4.283 mL |
50 mM |
0.0343 mL |
0.1713 mL |
0.3426 mL |
0.6853 mL |
0.8566 mL |
100 mM |
0.0171 mL |
0.0857 mL |
0.1713 mL |
0.3426 mL |
0.4283 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Structure Identification: |
Journal of Asian Natural Products Research, 2008,10(5):447-451. | New spermidines from the florets of Carthamus tinctorius.[Reference: WebLink] | METHODS AND RESULTS:
Two new spermidine compounds, namely Safflospermidine A (1) and safflospermidine B (2), together with two known compounds, N 1,N 5,N 10-(Z)-tri-p-coumaroylspermidine (3) and N 1,N 5,N 10-(E)-tri-p-coumaroylspermidine (4), were isolated from the florets of Carthamus tinctorius L. Their structures were elucidated by spectroscopic means. |
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