Tenacigenoside A | CAS:920502-42-7 | Manufacturer ChemFaces

Tenacigenoside A

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Description:

Tenacigenoside A and 11α-O-benzoyl-12β-O-acetyltenacigenin B (TGTB) can significantly increase tumor cell apoptosis on lymphoma bearing mice primarily through down-regulation of BCL2 and BCL-XL, and up-regulation of BID.

Targets:

Bcl-2/Bax

In vitro:

Leuk Lymphoma. 2015 May 5:1-30.

Marsdenia tenacssima and its functional components inhibits proliferation, induces apoptosis of human Burkitt's leukemia/lymphoma cell in vitro and in vivo.[Pubmed: 25942381]

Burkitt lymphoma is a fast growing non-Hodgkin lymphoma that occurs primarily in young males. The causes of Burkitt lymphoma include chromosome rearrangement and virus infection, but accurate and complete reasons remain to be discovered. The available treatment for Burkitt lymphoma is chemotherapy and radiation therapy. It is a highly aggressive B-cell neoplasm with not all patients cured, in spite of current therapies.
METHODS AND RESULTS:
This study evaluated the effects of traditional Chinese medicine Marsdenia tenacssima (MTE) and its component compound Tenacigenoside A (TGTA) and 11α-O-benzoyl-12β-O-acetyltenacigenin B (TGTB) on human Burkitt lymphoma growth. It was observed that MTE, TGTA or TGTB inhibited cell growth and induced apoptosis of Burkitt lymphoma cells in culture. In lymphoma bearing NOD/SCID nude mice, both TGTA and TGTB inhibited tumor growth and improved animal survival.
CONCLUSIONS:
TGTA and TGTB significantly increased tumor cell apoptosis on lymphoma bearing mice, primarily through down-regulation of BCL2 and BCL-XL and up-regulation of BID.

Tenacigenoside A Description

Source:	The herbs of Marsdenia tenacissima
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Tenacigenoside A
Price:
CAS No.:	920502-42-7
Catalog No.:	CFN97482
Molecular Formula:	C₃₅H₅₆O₁₂
Molecular Weight:	668.8 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Marsdenia tenacissima
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Pro-apoptotic Compound Library Steroids Compound Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4952 mL	7.4761 mL	14.9522 mL	29.9043 mL	37.3804 mL
5 mM	0.299 mL	1.4952 mL	2.9904 mL	5.9809 mL	7.4761 mL
10 mM	0.1495 mL	0.7476 mL	1.4952 mL	2.9904 mL	3.738 mL
50 mM	0.0299 mL	0.1495 mL	0.299 mL	0.5981 mL	0.7476 mL
100 mM	0.015 mL	0.0748 mL	0.1495 mL	0.299 mL	0.3738 mL

CFN97496	Tenacissoside F	928151-78-4	668.8	C₃₅H₅₆O₁₂
CFN97605	Marsdenoside F	858360-61-9	752.90	C₃₉H₆₀O₁₄
CFN90877	3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B	1260252-18-3	781.0	C₄₁H₆₄O₁₄
CFN90428	Tenacissoside H	191729-45-0	794.97	C₄₂H₆₆O₁₄
CFN97795	Tenacissoside G	191729-43-8	792.96	C₄₂H₆₄O₁₄
CFN97794	Tenacissoside I	191729-44-9	814.97	C₄₄H₆₂O₁₄
CFN97890	Dregeoside Da1	98665-65-7	815.0	C₄₂H₇₀O₁₅
CFN97588	Dregeoside Ga1	98665-66-8	941.17	C₄₉H₈₀O₁₇
CFN97790	Dregeoside Aa1	20230-41-5	939.15	C₄₉H₇₈O₁₇
CFN89258	Otophylloside F	250217-73-3	909.11	C₄₈H₇₆O₁₆