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|Size /Price /Stock
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More articles cited ChemFaces products.
Evid Based Complement Alternat Me...2017...Int Immunopharmacol.2022, 106:108603.South African J of Plant&Soil...2018...J Agric Food Chem....2019...Journal of Third Military Medical...2018...Vojnosanit Pregl2016, 75(00):391-391New Journal of Chemistry...2019...Pharmaceuticals (Basel)....2021...
Korea Institute of Oriental Medic...2020...Plants (Basel).2021, 10(5):951.J Cell Physiol.2020, 10.1002Crystals2020, 10(3), 206.Food Chem.2020, 327:126992.Food Chem Toxicol.2020, 135:110863Front Pharmacol.2021, 12:762829. The Korea Society of Pha.2014, 300-314
Applied Biological Chemistry...2020...Molecules.2019, 24(9):E1719Food Quality and Safety2018, 2:213-219Biomed Sci Letters.2020, 26:319-326J Appl Biol Chem.2021, 64(3),263?268Phytomedicine.2019, 61:152813Microb Biotechnol....2021...
Our products had been exported to the following research institutions and universities, And still growing.
Universidade Federal de Santa C... (Brazil)Ateneo de Manila University (Philippines)St. Jude Children Research Hosp... (USA)Seoul National University of Sc... (Korea)
University of Hawaii Cancer Center (USA)University of Lodz (Poland)Instytut Nawozów Sztucznych w ... (Poland)Cancer Research Initatives Foun... (Malaysia)
Universite Libre de Bruxelles (Belgium)National Research Council of Ca... (Canada)Max-Planck-Insitut (Germany)
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Front Pharmacol.2020, 11:566490.Plant Physiol Biochem.2021, 160:166-174.J Enzyme Inhib Med Chem.2019, 34(1):134-143Nutrients2022, 14(3),695.SBRAS2016, 12Plants (Basel).2021, 10(12):2795.Carbohydrate Polymer Technologies & App.2021, 2:100049.Earth Environ. Sci. 2021, 905:012080.South African J of Plant&Soil2018, 29-32Pharmaceuticals (Basel).2021, 14(8):742.
Related Screening Libraries
|| Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of terrestrosin D. |
|Pathobiology. 2014;81(3):123-32. |
|Terrestrosin D, a steroidal saponin from Tribulus terrestris L., inhibits growth and angiogenesis of human prostate cancer in vitro and in vivo.[Pubmed: 24642631]|
|The aim of this study was to investigate whether Terrestrosin D (TED) inhibits the progression of castration-resistant prostate cancer and consider its mechanism.
METHODS AND RESULTS:
Cell cycle, mitochondrial membrane potential (ΔΨm) and apoptosis were determined by flow cytometry. Caspase-3 activity and vascular endothelial growth factor secretion were detected by a caspase-3 assay and human vascular endothelial growth factor kit, respectively. A PC-3 xenograft mouse model was used to evaluate the anticancer effect of TED in vivo.
In vitro, TED strongly suppressed the growth of prostate cancer cells and endothelial cells in a dose-dependent manner. TED induced cell cycle arrest and apoptosis in PC-3 cells and human umbilical vascular endothelial cells (HUVECs). TED-induced apoptosis did not involve the caspase pathway. TED also decreased ΔΨm in PC-3 cells and HUVECs. In vivo, TED significantly suppressed tumor growth in nude mice bearing PC-3 cells, without any overt toxicity. Immunohistochemical analysis showed TED induced apoptotic cell death and inhibited angiogenesis in xenograft tumor cells.
Cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of TED.
Terrestrosin D Description
||The herbs of Tribulus terrestris L.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Phytochemistry. 1996 Jul;42(5):1417-22. |
|Steroidal saponins from fruits of Tribulus terrestris.[Pubmed: 9397208]|
METHODS AND RESULTS:
Further studies on the constituents of the fruits of Tribulus terrestris led to the isolation of five new steroidal saponins (terrestrosin A-E), (25R,S)-5 alpha-spirostan-3 beta-ol-3 -O-beta-D-galactopyranosyl(1-2)-beta-D- glucopyranosyl(1-4)-beta-D-galactopyranoside, (25R,S)-5 alpha-spirostan-3 beta-ol-3-O-beta-D-glucopyranosyl(1-4)-[alpha-L- rhamnopyranosyl(1-2)]-beta-D-galactopyranoside, (25R,S)-5 alpha-spirostan-12-on-3 beta-ol-3-O-beta-D-galactopyranosyl (1-2)-beta-D-glucopyranosyl(1-4)-beta-D-galactopyranoside, hecogenin 3-O-beta-D-galactopyranosyl)1-2)-[beta-D- xylopyranosyl(1-3)]-beta-D-glucopyranosyl(1-4)-beta-D-galactopyranoside and (25R,S)-5 alpha-spirostane-2 alpha, 3 beta-diol-3- O-beta-D-galactopyranosyl(1-2)-beta-D-glucopyranosyl(1-4)-beta-D- galactopyranoside, together with five known steroidal saponins, desgalactotigonin, F-gitonin, desglucolanatigonin, gitonin and tigogenin 3-O-beta-D- xylopyranosyl)1-2)-[beta-D-xylopyranosyl)1-3)]-beta-D-glucopyranosyl)1-4 )- [alpha-L-rhamnopyranosyl(1-2)]-beta-D-galactopyranoside.
The structures of the new saponins were elucidated on the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions.