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    Natural Products
    Thamnosmonin
    Information
    CAS No. 60094-90-8 Price
    Catalog No.CFN96622Purity>=98%
    Molecular Weight276.28Type of CompoundCoumarins
    FormulaC15H16O5Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Thamnosmonin

    Thamnosmonin
    Product Name Thamnosmonin
    CAS No.: 60094-90-8
    Catalog No.: CFN96622
    Molecular Formula: C15H16O5
    Molecular Weight: 276.28 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Source: The roots of Citrus sinensis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Front Pharmacol.2017, 8:205
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Coumarins Compound Library
  • Biological Activity
    Description: Thamnosmonin is a natural product from Citrus sinensis.
    In vitro:
    Phytother Res. 2007 Apr;21(4):386-90.
    Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.[Pubmed: 17236173 ]

    METHODS AND RESULTS:
    Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and Thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin.
    CONCLUSIONS:
    Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein.
    Thamnosmonin Description
    Source: The roots of Citrus sinensis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6195 mL 18.0976 mL 36.1952 mL 72.3903 mL 90.4879 mL
    5 mM 0.7239 mL 3.6195 mL 7.239 mL 14.4781 mL 18.0976 mL
    10 mM 0.362 mL 1.8098 mL 3.6195 mL 7.239 mL 9.0488 mL
    50 mM 0.0724 mL 0.362 mL 0.7239 mL 1.4478 mL 1.8098 mL
    100 mM 0.0362 mL 0.181 mL 0.362 mL 0.7239 mL 0.9049 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Zhong Yao Cai. 2013 May;36(5):744-6.
    Study on the chemical constituents from ethyl acetate extract of Micromelum falcatum.[Pubmed: 24218965]
    To study the chemical constituents from ethyl acetate extract of Micromelum falcatum.
    METHODS AND RESULTS:
    The constituents were separated and purified by silica gel, Sephadex LH-20 and HPLC. Their structures were elucidated by spectral analysis (NMR, MS). Ten compounds were isolated and identified as micropubescin (1), phebalosin (2), scopoletin (3), citrubuntin (4), Thamnosmonin (5), hopeyhopin (6), arnottinin (7), casegravol (8), 2-methoxy-5-hydroxy cinnamate (9), threo-syringoylglycerol (10).
    CONCLUSIONS:
    Compounds 1 - 10 are obtained from this plant for the first time.
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