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Uncarine A
Uncarine A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Uncarine A
Price:
CAS No.: 6899-73-6
Catalog No.: CFN89492
Molecular Formula: C21H24N2O4
Molecular Weight: 368.42 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The leaves of Uncaria hirsuta.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Uncarine A is a natural product from Uncaria hirsuta.
Uncarine A Description
Source: The leaves of Uncaria hirsuta.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7143 mL 13.5715 mL 27.1429 mL 54.2859 mL 67.8573 mL
5 mM 0.5429 mL 2.7143 mL 5.4286 mL 10.8572 mL 13.5715 mL
10 mM 0.2714 mL 1.3571 mL 2.7143 mL 5.4286 mL 6.7857 mL
50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0857 mL 1.3571 mL
100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(17):2124-8.
Studies on alkalodial constituents in leaves of Uncaria hirsuta.[Pubmed: 19066056]
To study the alkaloidial constituents of the leaves of uncaria hirsuta.
METHODS AND RESULTS:
Some chromatographic methods were applied to isolate pure compounds and their structures were elucidated by spectroscopic methods. Eleven compounds were isolated and identified as 19-epi-3-iso-ajmalicine (1), 3-isoajmalicine (2), harman (3), mitraphylline (4), isomitraphylline (5), isorhynchophylline (6), corynoxine (7), rhynchophylline (8), isomitraphyllic acid (9), Uncarine A (10) and uncarine B (11).
CONCLUSIONS:
Compounds 1-9 were firstly isolated from this plant.
CFN89526Isomitraphylline4963-01-3368.42C21H24N2O4
CFN89492Uncarine A6899-73-6368.42C21H24N2O4
CFN9705611-Methoxyuncarine C61665-08-5398.5 C22H26N2O5
CFN98460Vineridine3489-06-3398.5 C22H26N2O5
CFN98901Caboxine A53851-13-1398.5 C22H26N2O5
CFN99819Isocarapanaubine17391-09-2428.5 C23H28N2O6
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